論文

査読有り
2017年9月

Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

PEDIATRIC BLOOD & CANCER
  • Tomoo Osumi
  • ,
  • Motohiro Kato
  • ,
  • Meri Ouchi-Uchiyama
  • ,
  • Daisuke Tomizawa
  • ,
  • Keisuke Kataoka
  • ,
  • Yoichi Fujii
  • ,
  • Masafumi Seki
  • ,
  • Junko Takita
  • ,
  • Seishi Ogawa
  • ,
  • Toru Uchiyama
  • ,
  • Kentaro Ohki
  • ,
  • Nobutaka Kiyokawa

64
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/pbc.26496
出版者・発行元
WILEY

Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1002/pbc.26496
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406248200026&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-8263-9902

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