Takeshi Yoshida

Profile Information

Affiliation: Senior Reseach Scientist, National Institute of Infectious Diseases

Degree: 博士（医学）(京都大学)

Researcher number: 00727521
J-GLOBAL ID: 201401061969631498
researchmap Member ID: 7000009494

なぜウイルス学を研究しているのか？ 1.「宿主を乗っ取ることにより増殖する」ウイルスの性質が面白いから 2.「ウイルスが迅速に進化する性質」が面白いから 3.ウイルスが宿主蛋白質を乗っ取る性質を標的に新規抗HIV-1戦略を描けるのか？

Research Interests

Research Areas

Life sciences / Virology /

Research History

Apr, 2015 - Jan, 2022

Assistant Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Molecular Virology, Tokyo Medical and Dental University
Nov, 2013 - Mar, 2015

Primate Research Institute, Kyoto University

Education

Apr, 2005 - Mar, 2009

Graduate School, Division of Medicine, Kyoto University
Apr, 2003 - Mar, 2005

Graduate School, Division of Medicine, Tohoku University
Apr, 1999 - Mar, 2003

Faculty of Agriculture, Tohoku University

Papers

Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques

Hirotaka Ode, Akatsuki Saito, Ayaka Washizaki, Yohei Seki, Takeshi Yoshida, Shigeyoshi Harada, Hiroshi Ishii, Tatsuo Shioda, Yasuhiro Yasutomi, Tetsuro Matano …

Journal of General Virology, 103(10), Oct 7, 2022 Peer-reviewed
Simian Immunodeficiency Virus SIVgsn-99CM71 Vpu Employs Different Amino Acids To Antagonize Human and Greater Spot-Nosed Monkey BST-2.

Weitong Yao, Klaus Strebel, Shoji Yamaoka, Takeshi Yoshida

Journal of virology, 96(4) e0152721, Feb 23, 2022 Peer-reviewed
Editorial: Novel Insights Into a Functional HIV Cure.

Luca Sardo, Cristina Parolin, Takeshi Yoshida, Alfredo Garzino-Demo, Taisuke Izumi

Frontiers in microbiology, 12 797570-797570, 2021
Vpu of a simian immunodeficiency virus isolated from greater spot-nosed monkey antagonizes human BST-2 via two AxxxxxxxW motifs.

Yao W, Yoshida T, Hashimoto S, Takeuchi H, Strebel K, Yamaoka S

Journal of virology, 94(2) e01669-19, Jan, 2020 Peer-reviewed
PATZ1 is required for efficient HIV-1 infection.

Aziati ID, Yoshida T, Hamano A, Maeda K, Takeuchi H, Yamaoka S

Biochemical and biophysical research communications, 514(2) 538-544, Jun, 2019 Peer-reviewed
Robust Enhancement of Lentivirus Production by Promoter Activation.

Suzuki N, Yoshida T, Takeuchi H, Sakuma R, Sukegawa S, Yamaoka S

Scientific reports, 8(1) 15036, Oct, 2018 Peer-reviewed
eIF4A2 is a host factor required for efficient HIV-1 replication

Jerry Kwame Ndzinu, Hiroaki Takeuchi, Hideki Saito, Takeshi Yoshida, Shoji Yamaoka

Microbes and Infection, 20(6) 346-352, Jun 1, 2018 Peer-reviewed
Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection

Takeshi Yoshida, Akiko Hamano, Asuka Ueda, Hiroaki Takeuchi, Shoji Yamaoka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493(1) 132-138, Nov, 2017
Functional antagonism of Rhesus Macaque and Chimpanzee BST-2 by HIV-1 Vpu Is mediated by cytoplasmic domain interactions

Takeshi Yoshida, Yoshio Koyanagi, Klaus Strebel

Journal of Virology, 87(24) 13825-13836, Dec, 2013 Peer-reviewed
Antibody-Mediated Enhancement of HIV-1 and HIV-2 Production from BST-2/Tetherin-Positive Cells

Eri Miyagi, Amy Andrew, Sandra Kao, Takeshi Yoshida, Klaus Strebel

JOURNAL OF VIROLOGY, 85(22) 11981-11994, Nov, 2011 Peer-reviewed
Some Human Immunodeficiency Virus Type 1 Vpu Proteins Are Able To Antagonize Macaque BST-2 In Vitro and In Vivo: Vpu-Negative Simian-Human Immunodeficiency Viruses Are Attenuated In Vivo

Masashi Shingai, Takeshi Yoshida, Malcolm A. Martin, Klaus Strebel

JOURNAL OF VIROLOGY, 85(19) 9708-9715, Oct, 2011 Peer-reviewed
Lineage analysis of newly generated neurons in organotypic culture of rat hippocampus

Jun Yokose, Toru Ishizuka, Takeshi Yoshida, Jun Aoki, Yoshio Koyanagi, Hiromu Yawo

NEUROSCIENCE RESEARCH, 69(3) 223-233, Mar, 2011 Peer-reviewed
Identification of residues in the BST-2 TM domain important for antagonism by HIV-1 Vpu using a gain-of-function approach

Takeshi Yoshida, Sandra Kao, Klaus Strebel

FRONTIERS IN MICROBIOLOGY, 2, 2011 Peer-reviewed
Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

Tomoko Kobayashi, Hirotaka Ode, Takeshi Yoshida, Kei Sato, Peter Gee, Seiji P. Yamamoto, Hirotaka Ebina, Klaus Strebel, Hironori Sato, Yoshio Koyanagi

JOURNAL OF VIROLOGY, 85(2) 932-945, Jan, 2011 Peer-reviewed
T cell-based functional cDNA library screening identified SEC14-like 1a carboxy-terminal domain as a negative regulator of human immunodeficiency virus replication

Emiko Urano, Reiko Ichikawa, Yuko Morikawa, Takeshi Yoshida, Yoshio Koyanagi, Jun Komano

VACCINE, 28 B68-B74, May, 2010 Peer-reviewed
N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4

Takeshi Yoshida, Hirotaka Ebina, Yoshio Koyanagi

MICROBIOLOGY AND IMMUNOLOGY, 53(11) 629-635, Nov, 2009 Peer-reviewed
Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species

Kei Sato, Seiji P. Yamamoto, Naoko Misawa, Takeshi Yoshida, Takayuki Miyazawa, Yoshio Koyanagi

RETROVIROLOGY, 6, Jun, 2009 Peer-reviewed
Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

Emiko Urano, Yumi Kariya, Yuko Futahashi, Reiko Ichikawa, Makiko Hamatake, Hidesuke Fukazawa, Yuko Morikawa, Takeshi Yoshida, Yoshio Koyanagi, Naoki Yamamoto …

FEBS LETTERS, 582(29) 4053-4058, Dec, 2008 Peer-reviewed
A CD63 mutant inhibits t-cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane

Takeshi Yoshida, Yuji Kawano, Kei Sato, Yoshinori Ando, Jun Aoki, Yoshiharu Miura, Jun Komano, Yuetsu Tanaka, Yoshio Koyanagi

TRAFFIC, 9(4) 540-558, Apr, 2008 Peer-reviewed
Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4

Yuko Futahashi, Jun Komano, Emiko Urano, Toru Aoki, Makiko Hamatake, Kosuke Miyauchi, Takeshi Yoshida, Yoshio Koyanagi, Zene Matsuda, Naoki Yamamoto

CANCER SCIENCE, 98(3) 373-379, Mar, 2007 Peer-reviewed

Misc.

HIV-1RNAの機能的分業の分子機序解明

芳田剛, 本田優輝, 増田貴夫, 山岡昇司

日本エイズ学会誌, 23(4), 2021
Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques

Shigeyoshi Harada, Yuta Hikichi, Yohei Seki, Akatsuki Saito, Takeshi Yoshida, Hirotaka Ode, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano …

JOURNAL OF MEDICAL PRIMATOLOGY, 47(5) 333-333, Oct, 2018
カニクイザルにおけるHIV‐1mt長期潜伏感染の解析

関洋平, 齊藤暁, 佐藤賢文, 原田恵嘉, 吉村和久, 大出裕高, 岩谷靖雅, 石井洋, SAIFULISLAM M, 芳田剛 …

日本エイズ学会誌, 19(4) 417-417, Nov 20, 2017
Long-term latency of HIV-1mt infection in cynomolgus macaques is reserved in follicular helper T lymphocytes

Yohei Seki, Akatsuki Saito, Yorifumi Sato, Shigeyoshi Harada, Hirotaka Ode, Hiroshi Ishii, Takeshi Yoshida, Megumi Murata, Hiroyuki Kangawa, Yuji Watanabe …

JOURNAL OF MEDICAL PRIMATOLOGY, 46(4) 190-190, Aug, 2017
R5指向性HIV-1mt感染カニクイザルによる新規エリートコントローラーモデルの開発

関洋平, 齊藤暁, 芳田剛, 佐藤賢文, 原田恵嘉, 吉村和久, 渡部祐司, 岩谷靖雅, 保富康宏, 俣野哲朗 …

第29回日本エイズ学会学術集会・総会, 17(4) 334-334, 2015 Peer-reviewed
レンチウイルスベクターを用いた抗HIV因子のスクリーニングとその解析

小林朋子, 芳田剛, 駒野淳, 小柳義夫

日本エイズ学会誌, 10(4) 506-506, Nov, 2008

Presentations

ウイルスの宿主適応メカニズム：宿主防御機構とのせめぎ合いと攻略能獲得まで

芳田剛, Weitong Yao, 橋本紗希, 武内寛明, 山岡昇司

第34回日本エイズ学会学術集会, Nov 28, 2020, 日本エイズ学会 Invited
Identification of a host factor supporting HIV-1 entry

Takeshi Yoshida, Saki Kawamura, Haruka Yamaguchi, Hiroaki Takeuchi, Shoji Yamaoka

Dec 4, 2018
An SIV Vpu can antagonize human BST-2/tetherin

Takeshi Yoshida, Weitong Yao, Saki Hashimoto, Hiroaki Takeuchi, Shoji Yamaoka

第66回日本ウイルス学会学術集会, Oct 28, 2018
Species-specificity and Mechanism of viral protein U (Vpu) expressed by primate immunodeficiency viruses

Saki Hashimoto, Takeshi Yoshida, Hiroaki Takeuchi, Shoji Yamaoka

Nov 24, 2017
Identification of a new host factor inhibiting HIV-1 replication

Takeshi Yoshida, Akiko Hamano, Hiroaki Takeuchi, Shoji Yamaoka

Nov 24, 2016, The Japanese Society for AIDS Research
Is HIV-1 Vpu Oligomerization Required for Its Functions?

Dec 1, 2015
HIV-1mt感染カニクイザルによる新規エリートコントローラーモデル

関洋平, 齊藤暁, 芳田剛, 佐藤賢文, 原田恵嘉, 吉村和久, 渡部祐司, 岩谷靖雅, 保富康宏, 俣野哲朗, 三浦智行, 明里宏文

第63回日本ウイルス学会学術集会, Nov 22, 2015
抗HIV‐1活性を持つ宿主因子の探索

芳田剛, 夏井拓真, 前田健二朗, 濱野章子, 山岡昇司

第63回日本ウイルス学会学術集会, Nov 22, 2015, 日本ウイルス学会
Novel elite controller model by HIV-1mt-infected cynomolgus macaques

Yohei Seki, Akatsuki Saito, Takeshi Yoshida, Yorifumi Sato, Shigeyoshi Harada, Kazuhisa Yoshimura, Yuji Watanabe, Yasumasa Iwatani, Yasuhiro Yasutomi, Tetsuro Matano, Tomoyuki Miura, Hirofumi Akari

33rd Annual Symposium on Nonhuman Primate Models for AIDS, Oct 13, 2015

Research Projects

Elucidation of the onset and persistent mechanism of retrovirus induced thrombocytopenia in macaques and evaluation of their risks.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

OKAMOTO MUNEHIRO, YOSHIDA Takeshi, HIGASHINO Atsunori, ISA Tadashi, NAKAMURA Shin-ichiro, NIIMI Sachi, KANEKO Akihisa, YOSHIKAWA Rokusuke, SHIMODE Sayumi, SAKAGUCHI Syoichi
霊長類免疫不全ウイルスの宿主域拡大を規定する機能の獲得メカニズムの解明

若手研究(B), 文部科学省/日本学術振興会, 2014 - 2015

芳田剛, 芳田剛

Other

Survival of the Fittest: How Primate Immunodeficiency Viruses Are Evolving

Feb, 2020 - Feb, 2020
「アフリカに生息するサルから分離されたサル免疫不全ウイルスのVpuタンパク質はヒトの抗ウイルスタンパク質BST-2の機能を妨害する」 ―今後起こり得る世界的規模の新規感染症発生のリスク評価への応用―

Jan, 2020 - Jan, 2020

Journal of Virology

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