論文

査読有り 国際誌
2013年12月6日

Oscillatory control of factors determining multipotency and fate in mouse neural progenitors.

Science (New York, N.Y.)
  • Itaru Imayoshi
  • ,
  • Akihiro Isomura
  • ,
  • Yukiko Harima
  • ,
  • Kyogo Kawaguchi
  • ,
  • Hiroshi Kori
  • ,
  • Hitoshi Miyachi
  • ,
  • Takahiro Fujiwara
  • ,
  • Fumiyoshi Ishidate
  • ,
  • Ryoichiro Kageyama

342
6163
開始ページ
1203
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/science.1242366
出版者・発行元
AMER ASSOC ADVANCEMENT SCIENCE

The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are coexpressed by neural progenitor cells. Here, we found by time-lapse imaging that these factors are expressed in an oscillatory manner by mouse neural progenitor cells. In each differentiation lineage, one of the factors becomes dominant. We used optogenetics to control expression of Ascl1 and found that, although sustained Ascl1 expression promotes neuronal fate determination, oscillatory Ascl1 expression maintains proliferating neural progenitor cells. Thus, the multipotent state correlates with oscillatory expression of several fate-determination factors, whereas the differentiated state correlates with sustained expression of a single factor.

Web of Science ® 被引用回数 : 291

リンク情報
DOI
https://doi.org/10.1126/science.1242366
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201402209019667799
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24179156
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327857900039&DestApp=WOS_CPL
ID情報
  • DOI : 10.1126/science.1242366
  • ISSN : 0036-8075
  • eISSN : 1095-9203
  • J-Global ID : 201402209019667799
  • PubMed ID : 24179156
  • Web of Science ID : WOS:000327857900039

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