論文

査読有り 国際誌
2013年8月

Oscillatory links of Fgf signaling and Hes7 in the segmentation clock.

Current opinion in genetics & development
  • Yukiko Harima
  • ,
  • Ryoichiro Kageyama

23
4
開始ページ
484
終了ページ
90
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.gde.2013.02.005

Somitogenesis is controlled by the segmentation clock, where the oscillatory expression of cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for somite formation. Fgf signaling induces the oscillatory expression of Hes7 while Hes7 drives coupled oscillations in Fgf and Notch signaling, which inhibits and activates Mesp2 expression, respectively. Because of different oscillatory dynamics, oscillation in Fgf signaling dissociates from oscillation in Notch signaling in S-1, a prospective somite region, where Notch signaling induces Mesp2 expression when Fgf signaling becomes off. Thus, oscillation in Fgf signaling regulates the timing of Mesp2 expression and the pace of somitogenesis. In addition, Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2, suggesting gene-environment interaction through this signaling.

リンク情報
DOI
https://doi.org/10.1016/j.gde.2013.02.005
CiNii Articles
http://ci.nii.ac.jp/naid/120005324908
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23465881
ID情報
  • DOI : 10.1016/j.gde.2013.02.005
  • CiNii Articles ID : 120005324908
  • PubMed ID : 23465881

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