2016年7月
A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- 巻
- 138
- 号
- 29
- 開始ページ
- 9037
- 終了ページ
- 9040
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jacs.6b04506
- 出版者・発行元
- AMER CHEMICAL SOC
The G-quadruplexes form highly stable nucleic acid structures, which are implicated in various biological processes in both DNA and RNA. Although DNA G-quadruplexes have been studied in great detail, biological roles of RNA G-quadruplexes have received less attention. Here, a screening of a chemical library permitted identification of a small-molecule tool that binds selectively to RNA G-quadruplex structures. The polyaromatic molecule, RGB-1, stabilizes RNA G-quadruplex, but not DNA versions or other RNA structures. RGB-1 intensified the G-quadruplex-mediated inhibition of RNA translation in mammalian cells, decreased expression of the NRAS proto-oncogene in breast cancer cells, and permitted identification of a novel sequence that forms G-quadruplex in NRAS mRNA. RGB-1 may serve as a unique tool for understanding cellular roles of RNA G-quadruplex structures.
- リンク情報
- ID情報
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- DOI : 10.1021/jacs.6b04506
- ISSN : 0002-7863
- PubMed ID : 27410677
- Web of Science ID : WOS:000380730000012