論文

査読有り
2016年7月

A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  • Yousuke Katsuda
  • ,
  • Shin-ichi Sato
  • ,
  • Lisa Asano
  • ,
  • Yoshitaka Morimura
  • ,
  • Tomoyuki Furuta
  • ,
  • Hiroshi Sugiyama
  • ,
  • Masaki Hagihara
  • ,
  • Motonari Uesugi

138
29
開始ページ
9037
終了ページ
9040
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/jacs.6b04506
出版者・発行元
AMER CHEMICAL SOC

The G-quadruplexes form highly stable nucleic acid structures, which are implicated in various biological processes in both DNA and RNA. Although DNA G-quadruplexes have been studied in great detail, biological roles of RNA G-quadruplexes have received less attention. Here, a screening of a chemical library permitted identification of a small-molecule tool that binds selectively to RNA G-quadruplex structures. The polyaromatic molecule, RGB-1, stabilizes RNA G-quadruplex, but not DNA versions or other RNA structures. RGB-1 intensified the G-quadruplex-mediated inhibition of RNA translation in mammalian cells, decreased expression of the NRAS proto-oncogene in breast cancer cells, and permitted identification of a novel sequence that forms G-quadruplex in NRAS mRNA. RGB-1 may serve as a unique tool for understanding cellular roles of RNA G-quadruplex structures.

リンク情報
DOI
https://doi.org/10.1021/jacs.6b04506
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27410677
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000380730000012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/jacs.6b04506
  • ISSN : 0002-7863
  • PubMed ID : 27410677
  • Web of Science ID : WOS:000380730000012

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