2020年9月
Catalytic RNA nano-objects formed by self-assembly of group I ribozyme dimers serving as unit structures.
Journal of bioscience and bioengineering
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- 巻
- 130
- 号
- 3
- 開始ページ
- 253
- 終了ページ
- 259
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jbiosc.2020.04.010
- 出版者・発行元
- Elsevier BV
Ribozymes with modular structures are attractive platforms for the construction of nanoscale RNA objects with biological functions. We designed group I ribozyme dimers as unit ribozyme dimers (Urds), which self-assembled to form their polymeric states and also oligomeric states with defined numbers of Urds. Assembly of Urds yielded catalytic ability of a pair of distinct ribozyme units to cleave two distinct substrates. The morphologies of the assembled ribozyme structures were observed directly by atomic force microscopy (AFM).
- リンク情報
- ID情報
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- DOI : 10.1016/j.jbiosc.2020.04.010
- ISSN : 1389-1723
- PubMed ID : 32451246