2005年4月
UVR-induced G-C to C-G transversions from oxidative DNA damage
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- ,
- 巻
- 571
- 号
- 1-2
- 開始ページ
- 33
- 終了ページ
- 42
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.mrfmmm.2004.10.010
- 出版者・発行元
- ELSEVIER SCIENCE BV
Many oxidizing agents induce G-C to T-A and G-C to C-G transversions, and the frequency largely depends on the oxidative conditions. Guanine is the most oxidizable base among natural bases. The typical oxidative lesion product 8-oxoguanine (8-oxoG) is responsible for G-C to T-A transversion but not for G-C to C-G transversion, and 8-oxoG is more readily oxidized than guanine because of its lowered ionization potential. Recently, imidazolone (Iz), guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) have been demonstrated as oxidative lesion products of guanine and 8-oxoG, which could be responsible for G-C to C-G transversions by forming specific base pair formations. (c) 2005 Published by Elsevier B.V.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.mrfmmm.2004.10.010
- ISSN : 0027-5107
- PubMed ID : 15748636
- Web of Science ID : WOS:000227833400004