2010年
Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity
CHEMICAL COMMUNICATIONS
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- 巻
- 46
- 号
- 32
- 開始ページ
- 5942
- 終了ページ
- 5944
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1039/c0cc01286f
- 出版者・発行元
- ROYAL SOC CHEMISTRY
The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.
- リンク情報
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- DOI
- https://doi.org/10.1039/c0cc01286f
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002241516010606
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20601986
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280658300030&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1039/c0cc01286f
- ISSN : 1359-7345
- J-Global ID : 201002241516010606
- PubMed ID : 20601986
- Web of Science ID : WOS:000280658300030