2013年3月
Haemogenic endocardium contributes to transient definitive haematopoiesis
NATURE COMMUNICATIONS
- 巻
- 4
- 号
- 開始ページ
- 1564
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ncomms2569
- 出版者・発行元
- NATURE PUBLISHING GROUP
Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic lineages, it remains unknown whether the mammalian heart tube serves as a haemogenic organ akin to the dorsal aorta. Here we examine the haemogenic activity of the developing endocardium. Mouse heart explants generate myeloid and erythroid colonies in the absence of circulation. Haemogenic activity arises from a subset of endocardial cells in the outflow cushion and atria earlier than in the aorta-gonad-mesonephros region, and is transient and definitive in nature. Interestingly, key cardiac transcription factors, Nkx2-5 and Isl1, are expressed in and required for the haemogenic population of the endocardium. Together, these data suggest that a subset of endocardial/endothelial cells serve as a de novo source for transient definitive haematopoietic progenitors.
- リンク情報
- ID情報
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- DOI : 10.1038/ncomms2569
- ISSN : 2041-1723
- PubMed ID : 23463007
- Web of Science ID : WOS:000318873900018