2002年1月
The exocyst complex binds the small GTPase RaIA to mediate filopodia formation
NATURE CELL BIOLOGY
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- 巻
- 4
- 号
- 1
- 開始ページ
- 73
- 終了ページ
- 78
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ncb720
- 出版者・発行元
- NATURE PUBLISHING GROUP
The Ras-related small GTPase RalA is involved in controlling actin cytoskeletal remodelling and vesicle transport in mammalian cells(1,2). We identified the mammalian homologue of Sec5, a subunit of the exocyst complex determining yeast cell polarity, as a specific binding partner for GTP-ligated RalA. Inhibition of RalA binding to Sec5 prevents filopod production by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) and by activated forms of RalA and Cdc42, signalling intermediates downstream of these inflammatory cytokines. We propose that the RalA-exocyst complex interaction integrates the secretory and cytoskeletal pathways.
- リンク情報
- ID情報
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- DOI : 10.1038/ncb720
- ISSN : 1465-7392
- Web of Science ID : WOS:000173381500019