論文

査読有り
2017年4月

The Clinical Efficacy of Fibrinogen Concentrate in Massive Obstetric Haemorrhage with Hypofibrinogenaemia

SCIENTIFIC REPORTS
  • Shigetaka Matsunaga
  • ,
  • Yasushi Takai
  • ,
  • Eishin Nakamura
  • ,
  • Sumiko Era
  • ,
  • Yoshihisa Ono
  • ,
  • Koji Yamamoto
  • ,
  • Hiroo Maeda
  • ,
  • Hiroyuki Seki

7
開始ページ
46749
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep46749
出版者・発行元
NATURE PUBLISHING GROUP

Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion of large volumes of fresh frozen plasma (FFP) is required to normalise fibrinogen levels. We compared the efficacy of FFP (F group) with that of FFP plus fibrinogen concentrate (F + F group) in massive obstetric haemorrhage. In this retrospective study, we compared the medical charts (2004-2016) of 137 patients with < 150 mg/dl fibrinogen treated with F + F (n = 47; after August 2009) or F (n = 56; before August 2009). Although fibrinogen concentrate was only administered in severe cases, the FFP/red blood cell concentrate (RCC) ratio was significantly lower in the F + F group than in the F group. A sub-group analysis of cases requiring >= 18 RCC units showed that the F + F group received significantly less FFP than the F group (40.2 +/- 19.6 versus 53.4 +/- 18.5 units; P = 0.047) and showed significantly less pulmonary oedema (24.0% vs 57.1%; P < 0.05) in the absence of any significant differences in pre-transfusion coagulation, estimated blood loss, or RCC transfusion volume. Administration of fibrinogen concentrate increased the rate of fibrinogen supplementation five-fold and reduced FFP dosage, the FFP/RCC ratio, and the incidence of pulmonary oedema.

リンク情報
DOI
https://doi.org/10.1038/srep46749
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000400062400001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/srep46749
  • ISSN : 2045-2322
  • Web of Science ID : WOS:000400062400001

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