Aug, 2006
Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal and septic sheep
ANAESTHESIA AND INTENSIVE CARE
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- Volume
- 34
- Number
- 4
- First page
- 427
- Last page
- 433
- Language
- English
- Publishing type
- Publisher
- AUSTRALIAN SOC ANAESTHETISTS
The effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal.
We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0. 02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0 +/- 134.9 vs 472.1 +/- 163.8 ml/min, P<0.05) and a 14% decrease in mesenteric conductance (P<0.05). In septic sheep, APT decreased heart rate and cardiac output by 28% and 22%, respectively (P<0.05). It also decreased mesenteric blood flow and mesenteric conductance by 23% (flow: 468.5 +/- 159.7 vs 611.3 +/- 1363 ml/min, P<0.05; conductance: 63 +/- 2.7 vs 8.2 +/- 2.7 ml/min/mmHg; P<0.05). Renal blood flow was unchanged but urine output and creatinine clearance increased (P < 0.05). We conclude that low-dose AVP infusion has similar effects in the normal and septic mammalian circulation: bradycardia, decreased cardiac output, decreased mesenteric blood flow and conductance and increased urine output and creatinine clearance. This information is important to clinicians considering its administration in humans.
We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0. 02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0 +/- 134.9 vs 472.1 +/- 163.8 ml/min, P<0.05) and a 14% decrease in mesenteric conductance (P<0.05). In septic sheep, APT decreased heart rate and cardiac output by 28% and 22%, respectively (P<0.05). It also decreased mesenteric blood flow and mesenteric conductance by 23% (flow: 468.5 +/- 159.7 vs 611.3 +/- 1363 ml/min, P<0.05; conductance: 63 +/- 2.7 vs 8.2 +/- 2.7 ml/min/mmHg; P<0.05). Renal blood flow was unchanged but urine output and creatinine clearance increased (P < 0.05). We conclude that low-dose AVP infusion has similar effects in the normal and septic mammalian circulation: bradycardia, decreased cardiac output, decreased mesenteric blood flow and conductance and increased urine output and creatinine clearance. This information is important to clinicians considering its administration in humans.
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- ID information
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- ISSN : 0310-057X
- Web of Science ID : WOS:000240569100004