Jul, 2007
Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation
MINI-REVIEWS IN MEDICINAL CHEMISTRY
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- Volume
- 7
- Number
- 7
- First page
- 745
- Last page
- 753
- Language
- English
- Publishing type
- Book review, literature introduction, etc.
- DOI
- 10.2174/138955707781024517
- Publisher
- BENTHAM SCIENCE PUBL LTD
Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (1401), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.
- Link information
- ID information
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- DOI : 10.2174/138955707781024517
- ISSN : 1389-5575
- Web of Science ID : WOS:000247146700007