2011年9月15日
The period of the somite segmentation clock is sensitive to Notch activity
Molecular Biology of the Cell
- 巻
- 22
- 号
- 18
- 開始ページ
- 3541
- 終了ページ
- 3549
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1091/mbc.e11-02-0139
- 出版者・発行元
- American Society for Cell Biology (ASCB)
The number of vertebrae is defined strictly for a given species and depends on the number of somites, which are the earliest metameric structures that form in development. Somites are formed by sequential segmentation. The periodicity of somite segmentation is orchestrated by the synchronous oscillation of gene expression in the presomitic mesoderm (PSM), termed the “somite segmentation clock,” in which Notch signaling plays a crucial role. Here we show that the clock period is sensitive to Notch activity, which is fine-tuned by its feedback regulator, Notch-regulated ankyrin repeat protein (Nrarp), and that Nrarp is essential for forming the proper number and morphology of axial skeleton components. Null-mutant mice for Nrarp have fewer vertebrae and have defective morphologies. Notch activity is enhanced in the PSM of the Nrarp−/– embryo, where the ∼2-h segmentation period is extended by 5 min, thereby forming fewer somites and their resultant vertebrae. Reduced Notch activity partially rescues the Nrarp−/– phenotype in the number of somites, but not in morphology. Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs.
- リンク情報
-
- DOI
- https://doi.org/10.1091/mbc.e11-02-0139
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21795391
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172277
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000294823200023&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1091/mbc.e11-02-0139
- ISSN : 1059-1524
- eISSN : 1939-4586
- PubMed ID : 21795391
- PubMed Central 記事ID : PMC3172277
- Web of Science ID : WOS:000294823200023