2005年5月
Innervation of stem cell-derived neurons into auditory epithelia of mice
NEUROREPORT
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- 巻
- 16
- 号
- 8
- 開始ページ
- 787
- 終了ページ
- 790
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/00001756-200505310-00001
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice for 7 days. Histological analysis demonstrated massive elongation of neurites from embryonic stem cell-derived neurons toward auditory hair cells. Embryonic stem cell-derived neurites were adjacent to or surrounding hair cells, and exhibited expression of synaptophysin, a marker for synaptic vesicles. These findings demonstrate the ability of embryonic stem cell-derived neurons for reinnervation into auditory epithelia, indicating a high potential of embryonic stem cell-derived neurons as transplants for replacing spiral ganglion neurons. NeuroReport 16:787-790 (c) 2005 Lippincott Williams & Wilkins.
- リンク情報
- ID情報
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- DOI : 10.1097/00001756-200505310-00001
- ISSN : 0959-4965
- eISSN : 1473-558X
- PubMed ID : 15891570
- Web of Science ID : WOS:000229845300001