論文

査読有り
2015年12月

Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells

CHEMISTRY LETTERS
  • Yuki Yasueda
  • ,
  • Tomonori Tamura
  • ,
  • Keiko Kuwara
  • ,
  • Yousuke Takaoka
  • ,
  • Itaru Hamachi

44
12
開始ページ
1673
終了ページ
1675
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1246/cl.150797
出版者・発行元
CHEMICAL SOC JAPAN

Membrane proteins play crucial roles in fundamental biological processes. Here, we propose a new chemical strategy to label and characterize membrane proteins on cell surface. In this study, 4-dimethylaminopyridine (DMAP) is embedded and concentrated on plasma membrane surface (biomembrane-embedded DMAP: BeD), allowing to selectively modify membrane proteins with synthetic probes such as a fluorophore and an affinity tag. We applied this strategy to human red blood cells, which demonstrated that membrane proteins such as PAS-1 and Band-3 were selectively labeled.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1246/cl.150797
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000365933300014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1246/cl.150797
  • ISSN : 0366-7022
  • eISSN : 1348-0715
  • Web of Science ID : WOS:000365933300014

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