Kazuhisa Chonabayashi

Profile Information

Affiliation: Department of Hematology, Kyoto University Hospital

J-GLOBAL ID: 201401068582609383
researchmap Member ID: 7000010493

Research Areas

Life sciences / Hematology and oncology /

Papers

CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.

Misato Nakanishi-Koakutsu, Kenji Miki, Yuki Naka, Masako Sasaki, Takayuki Wakimizu, Stephanie C Napier, Chikako Okubo, Megumi Narita, Misato Nishikawa, Reo Hata …

Communications biology, 7(1) 231-231, Feb 28, 2024
Successful treatment with cyclosporine of pure red cell aplasia induced by obinutuzumab bendamustine therapy.

Yutaka Shimazu, Chisaki Mizumoto, Kazuhisa Chonabayashi, Yuta Hanyu, Junya Kanda, Akifumi Takaori-Kondo

Annals of hematology, Apr 27, 2023
Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa …

Circulation. Arrhythmia and electrophysiology, 16(3) e011387, Mar 3, 2023
がん研究における女性研究者不均衡転座der(1;7)(q10;p10)を有するMDSと関連疾患の特徴(Unbalanced translocation der(1;7)(q10;p10) as a distinct subtype in myelodysplastic syndromes)

奥田瑠璃花, 越智陽太郎, 蝶名林和久, 眞田昌, 半田寛, 白石友一, 千葉滋, 石川隆之, 大屋敷一馬, 熱田由子 …

日本癌学会総会記事, 81回 SS1-4, Sep, 2022
Disrupted Cav1.2 Selectivity Causes Overlapping Long QT and Brugada Syndrome Phenotypes in CACNA1C-E1115K iPS Cell Model.

Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas L Maurissen, Taisuke Ishikawa, Yuta Yamamoto, Yimin Wuriyanghai, Jingshan Gao, Hai Huang, Tomohiko Imamura …

Heart rhythm, 20(1) 89-99, Aug 22, 2022
Hematopoietic stem progenitor cells with malignancy-related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4.

Takamasa Katagiri, Jorge Luis Espinoza, Mizuho Uemori, Honoka Ikeda, Kohei Hosokawa, Ken Ishiyama, Takeshi Yoroidaka, Tatsuya Imi, Hiroyuki Takamatsu, Tatsuhiko Ozawa …

EJHaem, 3(3) 669-680, Aug, 2022
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting.

Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda …

Stem cell reports, 17(7) 1772-1785, Jul 12, 2022
The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β

Mikoto Tanabe, Kohei Hosokawa, Mai Anh Thi Nguyen, Noriharu Nakagawa, Kana Maruyama, Noriaki Tsuji, Ryota Urushihara, Luis Espinoza, Mahmoud I. Elbadry, Md Mohiuddin …

Leukemia, 36(3) 847-855, Mar, 2022 Peer-reviewed
Azacitidine is a potential therapeutic drug for pyridoxine-refractory female X-linked sideroblastic anemia

Yuki Morimoto, Kazuhisa Chonabayashi, Hiroshi Kawabata, Chikako Okubo, Makiko Yamasaki-Morita, Misato Nishikawa, Megumi Narita, Azusa Inagaki, Kayoko Nakanishi, Miki Nagao …

Blood Advances, 6(4) 1100-1114, Feb 22, 2022 Peer-reviewedCorresponding author
ETNK1変異の有無を特徴とするder(1;7)(q10;p10)を伴う骨髄異形成症候群

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, 牧島秀樹, 永田安伸, 真田昌, 白石友一, 宮野悟, 熱田由子 …

日本癌学会総会記事, 80回 [E7-2], Sep, 2021
ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes(和訳中)

奥田瑠璃花, 南谷泰人, 越智陽太郎, 蝶名林和久, 牧島秀樹, 吉里哲一, 永田安伸, 竹田淳恵, 吉田健一, 眞田昌 …

日本血液学会学術集会, 83回 OS1-4, Sep, 2021
Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs(和訳中)

中村桃子, 蝶名林和久, 森本有紀, 越智陽太郎, 南谷泰仁, 北脇年雄, 菱澤方勝, 小川誠司, 高折晃史, 吉田善紀

日本血液学会学術集会, 83回 OS2-3, Sep, 2021
骨髄異形成症候群におけるder(1;7)の民族的、臨床的、遺伝的特徴(Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes)

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, Creignou Maria, 牧島秀樹, 竹田淳恵, 昆彩奈, 宮野悟, 半田寛 …

日本癌学会総会記事, 79回 OE7-5, Oct, 2020
骨髄異形成症候群におけるder(1;7)の民族的、臨床的、遺伝的特徴(Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes)

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, Creignou Maria, 牧島秀樹, 竹田淳恵, 昆彩奈, 宮野悟, 半田寛 …

日本癌学会総会記事, 79回 OE7-5, Oct, 2020
Resistance of KIR Ligand-Missing Leukocytes to NK Cells In Vivo in Patients with Acquired Aplastic Anemia.

Mai Anh Thi Nguyen, Kohei Hosokawa, Takeshi Yoroidaka, Hiroyuki Maruyama, J Luis Espinoza, Mahmoud I Elbadry, Md Mohiuddin, Mikoto Tanabe, Takamasa Katagiri, Noriharu Nakagawa …

ImmunoHorizons, 4(7) 430-441, Jul 17, 2020 Peer-reviewed
Successful treatment of Hodgkin lymphoma-like EBV-associated post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation with nivolumab.

Fumiya Wada, Tadakazu Kondo, Momoko Nakamura, Kazuhisa Chonabayashi, Momoko Nishikori, Masakatsu Hishizawa, Kouhei Yamashita, Akifumi Takaori-Kondo

Annals of hematology, 99(4) 887-889, Apr, 2020 Peer-reviewed
Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model.

Sayako Hirose, Takeru Makiyama, Dario Melgari, Yuta Yamamoto, Yimin Wuriyanghai, Fumika Yokoi, Suguru Nishiuchi, Takeshi Harita, Mamoru Hayano, Hirohiko Kohjitani …

Frontiers in cell and developmental biology, 8 761-761, 2020 Peer-reviewed
A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.

Hiroki Mizumaki, Kazuyoshi Hosomichi, Kohei Hosokawa, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Takamasa Katagiri, Mai Anh Thi Nguyen, Dung Cao Tran, Mahmoud Ibrahim Yousef Elbadry …

Haematologica, in press, 2020 Peer-reviewed
Erratum: Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long qt syndrome type 1 patients (Stem Cells International (2019) 2019 (7532657) DOI: 10.1155/2019/7532657)

Tadashi Takaki, Azusa Inagaki, Kazuhisa Chonabayashi, Keiji Inoue, Kenji Miki, Seiko Ohno, Takeru Makiyama, Minoru Horie, Yoshinori Yoshida

Stem Cells International, 2020, 2020 Peer-reviewed
Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis.

Kazuhisa Chonabayashi, Yoshinori Yoshida, Toshio Kitawaki, Yasuhito Nannya, Momoko Nakamura, Shinichiro Oshima, Masakatsu Hishizawa, Kouhei Yamashita, Seishi Ogawa, Akifumi Takaori-Kondo

Annals of hematology, 98(12) 2841-2843, Dec, 2019 Peer-reviewedLead authorCorresponding author

Misc.

Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.

Rurika Okuda, Yasuhito Nannya, Yotaro Ochi, Kazuhisa Chonabayashi, Maria Creignou, Hideki Makishima, June Takeda, Ayana Kon, Satoru Miyano, Hiroshi Handa …

CANCER SCIENCE, 112 310-310, Feb, 2021
Elucidating the pathophysiology of AML with atypical 3q26 translocations using patient-derived iPSCs

中村桃子, 中村桃子, 蝶名林和久, 蝶名林和久, 森本有紀, 森本有紀, 越智陽太郎, 越智陽太郎, 南谷泰仁, 北脇年雄 …

日本血液学会学術集会抄録(Web), 83rd, 2021
ETNK1 mutations defines a subclass of der(1;7)(q10;p10) in myelodysplastic syndromes

奥田瑠璃花, 南谷泰人, 越智陽太郎, 蝶名林和久, 蝶名林和久, 牧島秀樹, 吉里哲一, 永田安伸, 竹田淳恵, 吉田健一 …

日本血液学会学術集会抄録(Web), 83rd, 2021
ETNK1変異の有無を特徴とするder(1;7)(q10;p10)を伴う骨髄異形成症候群

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, 蝶名林和久, 牧島秀樹, 永田安伸, 真田昌, 白石友一, 宮野悟 …

日本癌学会学術総会抄録集(Web), 80th, 2021
Der(1;7) 陽性骨髄異形成症候群における人種,臨床像,遺伝学的観点からみた特徴

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, 蝶名林和久, 牧島秀樹, 吉里哲一, 永田安伸, 竹田淳恵, 吉田健一 …

日本血液学会学術集会抄録(Web), 82nd, 2020
KCNQ1 Channel Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated With Long QT Syndrome

Yuta Yamamoto, Takeru M. Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura …

CIRCULATION, 140, Nov, 2019
Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System

YAMAMOTO Yuta, MAKIYAMA Takeru, WURIYANGHAI Yimin, KOHJITANI Hirohiko, HIROSE Sayako, GAO Jingshan, KASHIWA Asami, HUANG Hai, ISHIKAWA Taisuke, OHNO Seiko …

日本不整脈心電学会学術大会プログラム・抄録集(Web), 66th, 2019
Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, Mahmoud Ibrahim Elbadry, Hiroki Mizumaki, Luis Espinoza, Noriharu Nakagawa, Kazuhisa Chonabayashi, Yoshinori Yoshida, Takamasa Katagiri, Yoshitaka Zaimoku, Tatsuya Imi …

BLOOD, 132, Nov, 2018
疾患iPS細胞を用いたX連鎖性鉄芽球性貧血の病態解明(Modeling X-linked sideroblastic anemia with patient-derived human induced pluripotent stem cells)

森本有紀, 蝶名林和久, 川端浩, 高折晃史, 吉田善紀

臨床血液, 59(9) 1498-1498, Sep, 2018
リプログラミング技術を用いた骨髄異形成症候群の腫瘍内遺伝的・機能的多様性の解明

蝶名林和久, 吉田善紀, 高折晃史

臨床血液, 58(7) 787-791, Jul, 2017
I-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1C-associated long-QT syndrome

HARITA Takeshi, MAKIYAMA Takeru, TOYODA Futoshi, SASAKI Kenichi, NISHIUCHI Suguru, HAYANO Mamoru, YAMAMOTO Yuta, KOHJITANI Hirohiko, WURIYANGHAI Yimin, HIROSE Sayako …

Journal of Physiological Sciences, 67(Supplement 1), 2017
Ips Technology Revealed the Genetic and Functional Diversity Present in a Secondary AML Patient

Kazuhisa Chonabayashi, Masahiro Kawahara, Akira Watanabe, Masahiro Nakamura, Masatoshi Nishizawa, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida

BLOOD, 128(22), Dec, 2016
l-cis Diltiazem Rescues Impaired Calcium Channel Inactivation in a Patient-specific Stem Cell Model of Long QT Syndrome with a CACNA1C Mutation

HARITA Takeshi, MAKIYAMA Takeru, TOYODA Futoshi, SASAKI Kenichi, NISHIUCHI Suguru, HAYANO Mamoru, YAMAMOTO Yuta, KOHJITANI Hirohiko, WURIYANGHAI Yimin, HIROSE Sayako …

日本不整脈心電学会学術大会プログラム・抄録集(Web), 63rd, 2016
CALM遺伝子変異によるQT延長症候群の患者由来iPS細胞を用いた疾患モデルにおける変異アレル特異的ノックアウトによる治療的アプローチ

山本雄大, 牧山武, 張田健志, 佐々木健一, 早野護, 西内英, ウリヤンハイイミン, 糀谷泰彦, 廣瀬紗也子, チンカヨウ …

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.1P‐0016 (WEB ONLY), 2016
Generation of Ips Cell-Derived Hematopoietic Progenitor Cells from Patients with Acquired Aplastic Anemia Harboring Copy Number Neutral Loss of Heterozygosity of the Short Arm of Chromosome 6

Luis Espinoza, Yoshinori Yoshida, Kazuhisa Chonabayashi, Takamasa Katagiri, Yoshitaka Zaimoku, Shinji Nakao

BLOOD, 126(23), Dec, 2015
血液・免疫疾患 6.リプログラミング技術を用いた骨髄異形成症候群の病態解明と新規治療の可能性

蝶名林和久, 吉田善紀, 高折晃史

遺伝子医学MOOK, (27) 147-151, Feb 5, 2015
【iPS細胞を用いた難病研究-臨床病態解明と創薬に向けた研究の最新知見】 (第4章)血液・免疫疾患リプログラミング技術を用いた骨髄異形成症候群の病態解明と新規治療の可能性

蝶名林和久, 吉田善紀, 高折晃史

遺伝子医学MOOK, (27) 147-151, Feb, 2015
疾患特異的iPS細胞を活用した特発性造血障害の病態解析と新規治療法開発骨髄異形成症候群に関わる研究開発

蝶名林和久, 吉田善紀

疾患特異的iPS細胞を活用した特発性造血障害の病態解析と新規治療法の開発平成26年度委託業務成果報告書, 13‐17, 2015
Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Maturation Defect of Myelodysplastic Syndromes

Kazuhisa Chonabayashi, Masahiro Kawahara, Keisuke Okita, Masatoshi Nishizawa, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida

BLOOD, 124(21), Dec, 2014
iPS technology revealed the genetic and functional diversity present in a single MDS patient

Chonabayashi K, Kawahara M, Watanabe A, Amano N, Okita K, Nishizawa M, Kadowaki N, Takaori-Kondo A, Yamanaka S, Yoshida Y

臨床血液, 55(9) 1259, Sep, 2014

Research Projects

非定型3q26転座型骨髄性腫瘍のEVI1エピジェネティック制御機構解明と治療応用

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

蝶名林和久
Reprogramming technology revealed the genetic and functional diversity present in an individual myelodysplastic syndrome patient

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Chonabayashi Kazuhisa, Yoshida Yoshinori
Search for pathogenesis and novel therapeutics of acquired myelodysplastic syndromes using reprogramming technology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Chonabayashi Kazuhisa

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