Yuji Fukushima

Profile Information

Affiliation: Kyoto University

J-GLOBAL ID: 201401003434622058
researchmap Member ID: 7000010589

Research Interests

Research Areas

Research History

Apr, 2018 - Present

特定助教, 京都大学医学研究科
Apr, 2011 - Mar, 2017

研究員, 京都大学医学研究科
Apr, 2010 - Mar, 2011

特任助教, 広島大学生物圏科学研究科

Papers

Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays.

Yuji Fukushima, Nagahiro Minato, Masakazu Hattori

STAR protocols, 4(3) 102472-102472, Jul 28, 2023 Peer-reviewedInvitedCorresponding author
cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells.

Yuji Fukushima, Keiko Sakamoto, Michiyuki Matsuda, Yasunobu Yoshikai, Hideo Yagita, Daisuke Kitamura, Misaki Chihara, Nagahiro Minato, Masakazu Hattori

Cell reports, 40(12) 111373-111373, Sep 20, 2022 Peer-reviewedCorresponding author
CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi …

The Journal of clinical investigation, 132(2), Jan 18, 2022 Peer-reviewed
The impact of senescence-associated T cells on immunosenescence and age-related disorders

Fukushima Y, Minato N, Hattori M

Inflammation and regeneration, 38 24-24, 2018 Peer-reviewedInvited
The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.

Koyu Ito, Akira Nakajima, Yuji Fukushima, Keiichiro Suzuki, Keiko Sakamoto, Yoko Hamazaki, Kouetsu Ogasawara, Nagahiro Minato, Masakazu Hattori

PloS one, 12(3) e0173629, 2017 Peer-reviewed
Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.

Keiko Sakamoto, Yuji Fukushima, Koyu Ito, Michiyuki Matsuda, Shigekazu Nagata, Nagahiro Minato, Masakazu Hattori

Journal of immunology (Baltimore, Md. : 1950), 197(6) 2177-86, Sep 15, 2016 Peer-reviewed
A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

Suhail Tahir, Yuji Fukushima, Keiko Sakamoto, Kyosuke Sato, Harumi Fujita, Joe Inoue, Toshimitsu Uede, Yoko Hamazaki, Masakazu Hattori, Nagahiro Minato

JOURNAL OF IMMUNOLOGY, 194(12) 5725-5735, Jun, 2015 Peer-reviewed
Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity

Yuji Fukushima, Tomohiro Miyai, Manami Kumagae, Hiroyuki Horiuchi, Shuichi Furusawa

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 37(3-4) 354-362, Jul, 2012 Peer-reviewed
Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene

Yuji Fukushima, Masaharu Sato, Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi

JOURNAL OF POULTRY SCIENCE, 47(2) 144-148, Apr, 2010 Peer-reviewed
Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody

Mohamed Fahmy Abou Elazab, Yuji Fukushima, Yukihiro Fujita, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa

JOURNAL OF VETERINARY MEDICAL SCIENCE, 72(3) 257-262, Mar, 2010 Peer-reviewed
Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody

Mohamed Fahmy Abou Elazab, Yuji Fukushima, Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa

JOURNAL OF VETERINARY MEDICAL SCIENCE, 71(4) 417-424, Apr, 2009 Peer-reviewed
Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody

Miki Miyoshi, Hiroyuki Horiuchi, Yuji Fukushima, Haruo Matsuda, Shuichi Furusawaa

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 31(4) 394-406, 2007 Peer-reviewed

Misc.

T細胞の加齢変化と老化関連T細胞の病理学的関与

福島祐二, 服部雅一

臨床免疫・アレルギー科, 79(1) 8-14, Jan, 2023

Presentations

Senescence-associated CD4+ T cells and Autoimmune Pathology

Yuji Fukushima

The 52nd Annual Meeting of The Japanese Society for Immunology, International Symposium, DGFI-JSI Joint Session "Humoral Immunity", Jan, 2024 Invited
老化関連T細胞と自己免疫疾患

福島祐二

第５１回日本臨床免疫学会総会シンポジウム, Oct, 2023 Invited
CD153-CD30 interaction is involved in immunosenescence of T cells and spontaneous germinal center reactions

Fukushima Y, Yamada H, Yoshikai Y, Minato N, Hattori M

第４５回日本免疫学会学術集会, Dec, 2016

Professional Memberships

Research Projects

加齢変容性リンパ球が介在する多発性硬化症の病態機序解明とその制御

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2024 - Mar, 2028

福島祐二
非定型TCR複合体を形成する機能不全耐性T細胞集団の作出とがん治療への応用

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2025

福島祐二
免疫老化関連分子を活用した免疫監視機構の人為的強化

公益財団法人武田科学振興財団医学系研究助成, 2022

福島祐二
Control of senescence-associated T cell-induction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Hattori Masakazu
Study on the mechanism(s) of immunosenescence and its application for vaccine development.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

HATTORI Masakazu, MASHIMO Tomoji

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