2017年1月
SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation
CELL REPORTS
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- 巻
- 18
- 号
- 5
- 開始ページ
- 1298
- 終了ページ
- 1311
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.celrep.2017.01.004
- 出版者・発行元
- CELL PRESS
The inhalation of silica dust is associated with fibrosis and lung cancer, which are triggered by macrophage inflammatory responses; however, how macrophages recognize silica remains largely unknown. Here, we identify by functional expression cloning the class B scavenger receptor SR-B1 as a silica receptor. Through an extracellular alpha-helix, both mouse and human SR-B1 specifically recognized amorphous and crystalline silica, but not titanium dioxide nanoparticles, latex nanoparticles, or monosodium urate crystals, although all particles exhibited negative surface potentials. Genetic deletion of SR-B1 and masking of SR-B1 by monoclonal antibodies showed that SR-B1-mediated recognition of silica is associated with caspase-1-mediated inflammatory responses in mouse macrophages and human peripheral blood monocytes. Furthermore, SR-B1 was involved in silica-induced pulmonary inflammation in mice. These results indicate that SR-B1 is a silica receptor associated with canonical inflammasome activation.
- リンク情報
- ID情報
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- DOI : 10.1016/j.celrep.2017.01.004
- ISSN : 2211-1247
- Web of Science ID : WOS:000396477300018