MISC

2010年5月

Oxytocin Signal and Social Behaviour: Comparison among Adult and Infant Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice

JOURNAL OF NEUROENDOCRINOLOGY
  • H. Higashida
  • ,
  • O. Lopatina
  • ,
  • T. Yoshihara
  • ,
  • Y. A. Pichugina
  • ,
  • A. A. Soumarokov
  • ,
  • T. Munesue
  • ,
  • Y. Minabe
  • ,
  • M. Kikuchi
  • ,
  • Y. Ono
  • ,
  • N. Korshunova
  • ,
  • A. B. Salmina

22
5
開始ページ
373
終了ページ
379
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1111/j.1365-2826.2010.01976.x
出版者・発行元
WILEY

Oxytocin in the hypothalamus is the biological basis of social recognition, trust, love and bonding. Previously, we showed that CD38, a proliferation marker in leukaemia cells, plays an important role in the hypothalamus in the process of oxytocin release in adult mice. Disruption of Cd38 (Cd38 -/-) elicited impairment of maternal behaviour and male social recognition in adult mice, similar to the behaviour observed in Oxt and oxytocin receptor (Oxtr) gene knockout (Oxt -/- and Oxtr -/-, respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalisation calls was lower in Cd38 -/- than Cd38 +/+ pups. However, these behavioural changes were much milder than those observed in Oxt -/- and Oxtr -/- mice, indicating less impairment of social behaviour in Cd38 -/- pups. These phenotypes appeared to be caused by the high plasma oxytocin levels during development from the neonatal period to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of plasma oxytocin differentiation. Breastfeeding was an important exogenous source of plasma oxytocin regulation before weaning as a result of the presence of oxytocin in milk and the dam's mammary glands. The dissimilarity between Cd38 -/- infant behaviour and those of Oxt -/- or Oxtr -/- mice can be explained partly by this exogenous source of oxytocin. These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour.

Web of Science ® 被引用回数 : 69

リンク情報
DOI
https://doi.org/10.1111/j.1365-2826.2010.01976.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000276862100007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1365-2826.2010.01976.x
  • ISSN : 0953-8194
  • eISSN : 1365-2826
  • Web of Science ID : WOS:000276862100007

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