論文

査読有り
2015年9月

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice

FEBS LETTERS
  • Tokiharu Sato
  • ,
  • Momoe Ishikawa
  • ,
  • Toru Yoshihara
  • ,
  • Ryota Nakazato
  • ,
  • Haruhiro Higashida
  • ,
  • Masahide Asano
  • ,
  • Katsuji Yoshioka

589
19
開始ページ
2805
終了ページ
2811
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2015.08.024
出版者・発行元
ELSEVIER SCIENCE BV

JNK/stress-activated protein kinase-associated protein 1 (JSAP1) and JNK-associated leucine zipper protein (JLP) are structurally related scaffolding proteins that are highly expressed in the brain. Here, we found that JSAP1 and JLP play functionally redundant and essential roles in mouse cerebellar Purldnje cell (PC) survival. Mice containing PCs with deletions in both JSAP1 and JLP exhibited PC axonal dystrophy, followed by gradual, progressive neuronal loss. Kinesin-1 cargoes accumulated selectively in the swollen axons of Jsap1/Jlp-deficient PCs. In addition, autophagy inactivation in these mice markedly accelerated PC degeneration. These findings suggest that JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2015.08.024
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26320416
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000362619700022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.febslet.2015.08.024
  • ISSN : 0014-5793
  • eISSN : 1873-3468
  • PubMed ID : 26320416
  • Web of Science ID : WOS:000362619700022

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