論文

査読有り
2014年4月

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

FRONTIERS IN BEHAVIORAL NEUROSCIENCE
  • Olga Lopatina
  • ,
  • Toru Yoshihara
  • ,
  • Tomoko Nishimura
  • ,
  • Jing Zhong
  • ,
  • Shirin Akther
  • ,
  • Azam A. K. M. Fakhrul
  • ,
  • Mingkun Liang
  • ,
  • Chiharu Higashida
  • ,
  • Kohei Sumi
  • ,
  • Kazumi Furuhara
  • ,
  • Yuki Inahata
  • ,
  • Jian-Jung Huang
  • ,
  • Keita Koizumi
  • ,
  • Shigeru Yokoyama
  • ,
  • Takahiro Tsuji
  • ,
  • Yulia Petugina
  • ,
  • Andrei Sumarokov
  • ,
  • Alla B. Salmina
  • ,
  • Koji Hashida
  • ,
  • Yasuko Kitao
  • ,
  • Osamu Hori
  • ,
  • Masahide Asano
  • ,
  • Yoji Kitamura
  • ,
  • Takashi Kozaka
  • ,
  • Kazuhiro Shiba
  • ,
  • Fangfang Zhong
  • ,
  • Min-Jue Xie
  • ,
  • Makoto Sato
  • ,
  • Katsuhiko Ishihara
  • ,
  • Haruhiro Higashida

8
開始ページ
133
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fnbeh.2014.00133
出版者・発行元
FRONTIERS MEDIA SA

CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157(-/-)) male mice under less aging-related effects on behaviors. CD157(-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157(-/-) mice than in wild-type mice. These results demonstrate for the first time that CD 157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.

Web of Science ® 被引用回数 : 49

リンク情報
DOI
https://doi.org/10.3389/fnbeh.2014.00133
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24795584
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000334735200001&DestApp=WOS_CPL
ID情報
  • DOI : 10.3389/fnbeh.2014.00133
  • ISSN : 1662-5153
  • PubMed ID : 24795584
  • Web of Science ID : WOS:000334735200001

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