論文

査読有り
1998年12月14日

Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: Radial-arm maze performance in rats

Brain Research
  • Kouichi Kawabe
  • ,
  • Toru Yoshihara
  • ,
  • Yukio Ichitani
  • ,
  • Tsuneo Iwasaki

814
1-2
開始ページ
226
終了ページ
230
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0006-8993(98)01043-9

In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA (N-methyl-D-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of D-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial- maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801- induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors.

リンク情報
DOI
https://doi.org/10.1016/S0006-8993(98)01043-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9838131
ID情報
  • DOI : 10.1016/S0006-8993(98)01043-9
  • ISSN : 0006-8993
  • PubMed ID : 9838131
  • SCOPUS ID : 0032517756

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