Toru Yoshihara

Profile Information

Affiliation: Kyoto University

J-GLOBAL ID: 201501077408572477
researchmap Member ID: 7000011388

Research Interests

Research Areas

Life sciences / Basic brain sciences /

Papers

Long-lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains.

Momoe Sukegawa, Toru Yoshihara, Shengqun Hou, Masahide Asano, Anthony J Hannan, Dan Ohtan Wang

The European journal of neuroscience, 55(5) 1118-1140, Mar, 2022
Generation and analysis of voltage-gated calcium channel β<sub>4</sub> subunit conditional knock-out mice

Katsumi Hayashida, Akito Nakao, Toru Yoshihara, Masahide Asano, Yasuo Mori

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-P, 2022
α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

Norihito Uemura, Jun Ueda, Toru Yoshihara, Masashi Ikuno, Maiko T Uemura, Hodaka Yamakado, Masahide Asano, John Q Trojanowski, Ryosuke Takahashi

Movement disorders : official journal of the Movement Disorder Society, 36(9) 2036-2047, Feb 6, 2021
Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.

Hieu Hoang Trung, Toru Yoshihara, Akito Nakao, Katsumi Hayashida, Yoshiki Hirata, Koumei Shirasuna, Mitsuru Kuwamura, Yuki Nakagawa, Takehito Kaneko, Yasuo Mori …

Scientific reports, 11(1) 2039-2039, Jan 21, 2021
Abnormal social behavior and altered gene expression in mice lacking NDRG2

Mika Takarada-Iemata, Toru Yoshihara, Nahoko Okitani, Keiko Iwata, Tsuyoshi Hattori, Hiroshi Ishii, Jureepon Roboon, Dinh Thi Nguyen, Qiyan Fan, Takashi Tamatani …

Neuroscience Letters, 135563-135563, Dec, 2020
Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.

Chie Naruse, Kanae Abe, Toru Yoshihara, Tomoaki Kato, Takumi Nishiuchi, Masahide Asano

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3) 3956-3968, Mar, 2020 Peer-reviewed
Muscle weakness and impaired motor coordination in Hcn1-deficient rats.

Nishitani A, Yoshihara T, Tanaka M, Kuwamura M, Asano M, Tsubota Y, Kuramoto T

Experimental animals, Jul, 2019 Peer-reviewed
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.

Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R

Scientific reports, 9(1) 8251, Jun, 2019 Peer-reviewed
The Contributions of Cd38 and Cd157 Gene Deletion in Neurobehavioral Outcomes

Lopatina, Olga L, Kasai, Satoka, Cherepanov, Stanislav M, Furuhara, Kazumi, Yoshihara, Toru, Shabalova, Anna A, Gerasimenko, Maria N …

Messenger, 6(6) 99-104, Nov, 2018
Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice.

Toru Yoshihara, Hiroyuki Satake, Toshikazu Nishie, Nozomu Okino, Toshihisa Hatta, Hiroki Otani, Chie Naruse, Hiroshi Suzuki, Kazushi Sugihara, Eikichi Kamimura …

PLoS genetics, 14(8) e1007545, Aug, 2018 Peer-reviewed
Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

Toru Yoshihara, Hiroyuki Satake, Toshikazu Nishie, Nozomu Okino, Toshihisa Hatta, Hiroki Otani, Chie Naruse, Hiroshi Suzuki, Kazushi Sugihara, Eikichi Kamimura …

PLoS Genetics, 14(8) e1007545, Aug, 2018 Peer-reviewed
The Contributions of Cd38 and Cd157 Gene Deletion in Neurobehavioral Outcomes

Olga L. Lopatina, Satoka Kasai, Stanislav M. Cherepanov, Kazumi Furuhara, Toru Yoshihara, Anna A. Shabalova, Maria N. Gerasimenko, Chiharu Tsuji, Shigeru Yokoyama, Haruhiro Higashida …

Messenger, 6(1) 99-104, Jun 1, 2018
Possible Involvement of the Dopaminergic System in Emotional Deficiency in CD157/BST1Knockout Mice.

Toru Yoshihara, Kazuhiro Shiba, Katsuhiko Ishihara, Haruhiro Higashida

Messenger, 6(1-2) 94-98, Jun, 2018 Peer-reviewed
Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson's Disease

Satoka Kasai, Toru Yoshihara, Olga Lopatina, Katsuhiko Ishihara, Haruhiro Higashida

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 11 75, May, 2017 Peer-reviewed
An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

Haruhiro Higashida, Mingkun Liang, Toru Yoshihara, Shirin Akther, Azam Fakhrul, Cherepanov Stanislav, Tae-Sik Nam, Uh-Hyun Kim, Satoka Kasai, Tomoko Nishimura …

BMC NEUROSCIENCE, 18(1) 35, Mar, 2017 Peer-reviewed
Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons

Danko Georgiev, Toru Yoshihara, Rika Kawabata, Takurou Matsubara, Makoto Tsubomoto, Yoshio Minabe, David A. Lewis, Takanori Hashimoto

SCHIZOPHRENIA BULLETIN, 42(4) 992-1002, Jul, 2016 Peer-reviewed
Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice

Tokiharu Sato, Momoe Ishikawa, Toru Yoshihara, Ryota Nakazato, Haruhiro Higashida, Masahide Asano, Katsuji Yoshioka

FEBS LETTERS, 589(19) 2805-2811, Sep, 2015 Peer-reviewed
Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTP beta

Shohei Yaji, Hiroshi Manya, Naoki Nakagawa, Hiromu Takematsu, Tamao Endo, Reiji Kannagi, Toru Yoshihara, Masahide Asano, Shogo Oka

GLYCOBIOLOGY, 25(4) 376-385, Apr, 2015 Peer-reviewed
Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice.

Akira Mizuno, Stanislav M Cherepanov, Yusuke Kikuchi, Azam Akm Fakhrul, Shirin Akther, Kisaburo Deguchi, Toru Yoshihara, Katsuhiko Ishihara, Satoshi Shuto, Haruhiro Higashida

Brain sciences, 5(1) 3-13, Jan 20, 2015 Peer-reviewed
Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

Olga Lopatina, Toru Yoshihara, Tomoko Nishimura, Jing Zhong, Shirin Akther, Azam A. K. M. Fakhrul, Mingkun Liang, Chiharu Higashida, Kohei Sumi, Kazumi Furuhara …

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 8 133, Apr, 2014 Peer-reviewed

Misc.

Oxytocin Signal and Social Behaviour: Comparison among Adult and Infant Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice

H. Higashida, O. Lopatina, T. Yoshihara, Y. A. Pichugina, A. A. Soumarokov, T. Munesue, Y. Minabe, M. Kikuchi, Y. Ono, N. Korshunova …

JOURNAL OF NEUROENDOCRINOLOGY, 22(5) 373-379, May, 2010
オキシトシンとバソプレシン : 社会性認知行動と信頼の神経化学的基盤

東田陽博, 小泉恵太, 吉原亨

子どものこころと脳の発達, 1(1) 80-89, 2010
DIFFERENTIAL EFFECTS OF NMDA RECEPTOR BLOCKADE IN THE PREFRONTAL CORTEX AND HIPPOCAMPUS ON SPATIAL WORKING MEMORY IN RATS

Kazuko Hayashi, Toru Yoshihara, Yukio Ichitani

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 177-177, 2009
Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta-1,4-Galactosyltransferase-II-deficient mice

Toru Yoshihara, Kazushi Sugihara, Yasuhiko Kiduka, Shogo Oka, Masahide Asano

NEUROSCIENCE RESEARCH, 65 S188-S188, 2009
O-3-5 ラットの空間的・非空間的作業記憶課題の遂行における海馬内グルタミン酸受容体の役割

吉原亨, 林和子, 一谷幸男

動物心理学研究, 52(2) 130-130, Dec 25, 2002
P-2-2 ラットの放射状迷路課題遂行における海馬内代謝型グルタミン酸受容体の役割(2) : グループII受容体作動薬の効果

林和子, 吉原亨, 一谷幸男

動物心理学研究, 52(2) 153-153, Dec 25, 2002
P-1A-26 NMDA及びAMPA受容体拮抗薬海馬内投与ラットの放射状迷路行動 : 8選択肢と4選択肢課題による比較(日本動物心理学会第61回大会発表要旨)

吉原亨, 林和子, 一谷幸男

動物心理学研究, 51(2) 81-81, Dec 25, 2001
P-1A-27 ラットの放射状迷路課題遂行における海馬内代謝型グルタミン酸受容体の役割(1) : グループI受容体拮抗薬の効果(日本動物心理学会第61回大会発表要旨)

林和子, 吉原亨, 一谷幸男

動物心理学研究, 51(2) 81-81, Dec 25, 2001
A review of behavioral studies on the roles of inotropic and metabotropic glutamate receptors in learning and memory

Yoshihara Toru, Ichitani Yukio

Tsukuba psychological research, 23 25-34, 2001

Research Projects

脆弱な大脳皮質ニューロンによる生命維持機構の障害

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

吉原亨, 杉原一司, 浅野雅秀
Establishment of new ADHD model mice based on ganglioside deficiency

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Yoshihara Toru
Establishment of new mental disease model mouse by heterochromatin factor HP1 deficiency

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Yoshihara Toru
Study on neurological disorder caused by ganglioside-deficiency and therapeutics by glycolipid supplement

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Asano Masahide, Sugihara Kazushi
Reduced gene expression for Kv9.3 potassium channel subunit and cortical dysfunction in schizophrenia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Hashimoto Takanori, Lewis David A
Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Asano Masahide, NARUSE Chie, YOSHIHARA Toru, SUGIHARA Kazushi
Embryonic lipid metabolism dysfunction as etiology of developmental disorder

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

MATSUZAKI Hideo, YOSHIHARA Tohru, IWATA Keiko, IZUMO Nobuo, HATA Kenichiro, YAMANO Mariko
Analysis of glycan-related gene manipulated mice as new animal models of mental disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2013

YOSHIHARA Toru
The role of carbohydrates including galactose and sialic acids in higher brain functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

ASANO Masahide, YOSHIHARA Toru
Molecular mechanism of altered cannabinoid signaling in the pathophysiology of schizophrenia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

HASHIMOTO Takanori, YAMADA Kazuo, TODA Shigenobu, YOSHIHARA Toru, NISHIUCHI Takumi, GEORGIEV Danko
Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

ASANO Masahide, HASHIMOTO Noriyoshi, YOSHIHARA Toru, SUGIHARA Kazushi

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