論文

査読有り 責任著者
2015年2月

Treatment with Anti-Interleukin-6 Receptor Antibody Ameliorates Intestinal Polyposis in Apc(Min/+) Mice under High-Fat Diet Conditions

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
  • Takao Yaoita
  • Yu Sasaki
  • Junji Yokozawa
  • Takeshi Sato
  • Nana Kanno
  • Kazuhiro Sakuta
  • Makoto Yagi
  • Kazuya Yoshizawa
  • Daisuke Iwano
  • Ko Nagino
  • Eiki Nomura
  • Yasuhiko Abe
  • Shoichi Nishise
  • Hiroaki Takeda
  • Sumio Kawata
  • Yoshiyuki Ueno
  • 全て表示

235
2
開始ページ
127
終了ページ
134
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1620/tjem.235.127
出版者・発行元
TOHOKU UNIV MEDICAL PRESS

The prevalence of colorectal malignancies is increasing in the world. The parallel increase of metabolic syndrome gives a speculation between these two conditions, although the precise mechanism is still unclear. Interleukin-6 (IL-6) is a cytokine known to correlate with obesity and serve as a proinflammatory adipokine. In the present study, we investigated the effect of IL-6 signaling blockade on intestinal polyp formation in obesity using a mouse model of adenomatous polyposis coli (Apc). Male C57BL/6J-Apc(Min/+) mice were fed a high-fat diet from 5 weeks of age, and the overweight mice thus obtained were given a weekly intraperitoneal injection of anti-mouse IL-6 receptor antibody (MR16-1) from 6 to 15 weeks of age, while control mice received IgG or phosphate-buffered saline (PBS). The total number of intestinal polyps was significantly decreased in the MR16-1-injected group (53.1 +/- 6.8) relative to the control groups (PBS-injected, 81.3 +/- 6.1; rat IgG-injected, 74.7 +/- 4.8, p = 0.01), and in particular the number of polyps larger than 2 mm in diameter was markedly decreased. In addition, the mean diameter of polyps in the MR16-1-injected group was significantly smaller than that in the control groups. On the other hand, no significant differences in body weight, epididymal fat pad mass, or the plasma levels of glucose, insulin and triglyceride were observed among the three groups. Thus, treatment with anti-IL-6 receptor antibody suppressed polyp growth in obese Apc(Min/+) mice fed the high-fat diet. We suggest that IL-6 signaling may be responsible for the obesity-associated colorectal tumorigenesis.

リンク情報
DOI
https://doi.org/10.1620/tjem.235.127
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25746084
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000351187700007&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-3939-9480
ID情報
  • DOI : 10.1620/tjem.235.127
  • ISSN : 0040-8727
  • eISSN : 1349-3329
  • ORCIDのPut Code : 35401427
  • PubMed ID : 25746084
  • Web of Science ID : WOS:000351187700007
  • ORCIDで取得されたその他外部ID : a:1:{i:0;a:1:{s:0:"";s:0:"";}}

エクスポート
BibTeX RIS