内田和久 (Kazuhisa Uchida) - マイポータル - researchmap

基本情報

所属: 神戸大学大学院科学技術イノベーション研究科科学技術イノベーション専攻特命教授

学位: 修士（理学）(東京都立大学)

J-GLOBAL ID: 201501038979308585
researchmap会員ID: 7000011890

研究分野

1

ライフサイエンス / 薬系衛生、生物化学 /

学歴

1

- 1988年3月

東京都立大学大学院理学研究科修士課程化学専攻修了

論文

32

Tracking Particle‐Encapsulated DNA Across the Anion‐Exchange Chromatography Fractions of Recombinant Adeno‐Associated Virus Using Droplet Digital PCR and High‐Throughput Sequencing

Noriko Hashiba, Yuzhe Yuan, Emi Itou‐Kudo, Kyoko Masumi‐Koizumi, Keisuke Yusa, Kazuhisa Uchida

Biotechnology Journal 2025年6月
Encapsulation of a Single-Stranded Form of DNA Impurities into the Capsid of a Recombinant Adeno-Associated Virus

Kazuhisa Uchida, Emi Ito-Kudo, Kiyoko Higashiyama, Kyoko Masumi-Koizumi, Keisuke Yusa, Yuzhe Yuan

Human Gene Therapy 2025年5月1日
Database Chemistry for Genomics-Based Safety and Quality Evaluation of Biologics

Norichika Ogata, Tomoko Matsuda, Aoi Hosaka, Akihisa Shina, Noriko Hashiba, Kazuhisa Uchida, Yoshinori Kawabe, Masamichi Kamihira, Takanori Yamaoka, Hiromu Kurita …

2025年2月17日
Concise Analysis of Single-Stranded DNA of Recombinant Adeno-Associated Virus By Automated Electrophoresis System

Yuzhe Yuan, Kiyoko Higashiyama, Noriko Hashiba, Kyoko Masumi-Koizumi, Keisuke Yusa, Kazuhisa Uchida

Human Gene Therapy 2024年2月1日
Evaluation of next-generation sequencing performance for in vitro detection of viruses in biological products

Takamasa Hirai, Kiyoko Kataoka, Yuzhe Yuan, Keisuke Yusa, Yoji Sato, Kazuhisa Uchida, Ken Kono

Biologicals 2024年2月
Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for the Quantitative Characterization of Adeno-Associated Virus Vectors.

Kiichi Hirohata, Yuki Yamaguchi, Takahiro Maruno, Risa Shibuya, Tetsuo Torisu, Takayuki Onishi, Hideto Chono, Junichi Mineno, Yuan Yuzhe, Kiyoko Higashiyama …

Analytical chemistry 2024年1月2日査読有り
Association between adeno‐associated virus genomic titers and intracellular plasmid levels

Kyoko Masumi‐Koizumi, Yuzhe Yuan, Kiyoko Higashiyama, Keisuke Yusa, Kazuhisa Uchida

Engineering Reports 2024年1月
Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)

Tomofumi Nakada-Masuta, Hiroyuki Takeda, Kazuhisa Uchida

Marine Drugs 2023年10月24日
Novel Approach for Obtaining VNAR with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)

Tomofumi Nakada-Masuta, Hiroyuki Takeda, Kazuhisa Uchida

2023年10月3日
Association between adeno‐associated virus genomic titers and intracellular plasmid levels

Kyoko Masumi-Koizumi, yuzhe yuan, Kiyoko Higashiyama, Keisuke Yusa, KAZUHISA UCHIDA

Engineering Reports 2023年6月13日
Quantitation of Residual Host Cell DNA in Recombinant Adeno-Associated Virus Using Droplet Digital Polymerase Chain Reaction

Kiyoko Higashiyama, Yuzhe Yuan, Noriko Hashiba, Kyoko Masumi-Koizumi, Keisuke Yusa, Kazuhisa Uchida

Human Gene Therapy 2023年6月1日
Quantitation of Residual Host Cell DNA in Recombinant Adeno-Associated Virus Using Droplet Digital Polymerase Chain Reaction

Kiyoko Higashiyama, Yuzhe Yuan, Noriko Hashiba, Kyoko Masumi-Koizumi, Keisuke Yusa, KAZUHISA UCHIDA

Human Gene Therapy 34(11-12) 578-585 2023年6月1日
Investigating critical thermal parameters for pre-analytical preparation of adeno-associated virus vector genome titration by droplet digital polymerase chain reaction

Shunsuke SAITO, Akihiko KONDO, Kazuhisa UCHIDA

Translational and Regulatory Sciences 2023年
Practice of Human Resource Development Related to Biopharmaceutical Manufacturing and Quality Control and the International Contribution as Centers of Excellence of Asia-Pacific Economic Cooperation-Life Sciences Innovation Forum-Regulatory Harmonization Steering Committee

Kazuhisa Uchida

YAKUGAKU ZASSHI 142(7) 749-753 2022年7月1日
Infectivity assessment of porcine endogenous retrovirus using high-throughput sequencing technologies

Kono, K., Kataoka, K., Yuan, Y., Yusa, K., Uchida, K., Sato, Y.

Biologicals 71 2021年
Viral safety testing for biopharmaceuticals: Current and future prospects

Keisuke YUSA, Yuzhe YUSA, Kazuhisa UCHIDA

Translational and Regulatory Sciences 2(3) 94-99 2020年
A highly sensitive method for the detection of recombinant PERV-A/C env RNA using next generation sequencing technologies

Kono, K., Kataoka, K., Yuan, Y., Yusa, K., Uchida, K., Sato, Y.

Scientific Reports 10(1) 2020年
A chromatographic approach for elevating the antibody-dependent cellular cytotoxicity of antibody composites

Tojo, S., Okazaki, A., Wakitani, M., Shinkawa, T., Uchida, K., Suzawa, T.

Biological and Pharmaceutical Bulletin 32(9) 2009年
Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy

Yamaguchi, Y., Nishimura, M., Nagano, M., Yagi, H., Sasakawa, H., Uchida, K., Shitara, K., Kato, K.

Biochimica et Biophysica Acta - General Subjects 1760(4) 2006年
Enhanced Fc-dependent cellular cytotoxicity of Fc fusion proteins derived from TNF receptor II and LFA-3 by fucose removal from asn-linked oligosaccharides

Shoji-Hosaka, E., Kobayashi, Y., Wakitani, M., Uchida, K., Niwa, R., Nakamura, K., Shitara, K.

Journal of Biochemistry 140(6) 2006年

もっとみる

MISC

1

バイオ医薬品の製造・開発と規制上の課題

内田和久

レギュラトリーサイエンス学会誌 7(2) 121-129 2017年5月査読有り

担当経験のある科目(授業)

20

共同研究・競争的資金等の研究課題

1

バイオ医薬品の品質管理等に関わる人材育成プログラムの開発

日本医療研究開発機構創薬基盤推進研究事業 2015年

内田和久