© 2017 Taylor & Francis Group, London. In this study, a centrifuge model tests and effective stress analyses are performed on a steel frame building with pile-foundation subject to Tsunami such as those seriously damaged during the 2011 off the Pacific coast of Tohoku Earthquake (Magnitude 9.0). The centrifuge model tests at a scale of 1/200 in geometry are performed to simulate the overturning of a building subject to combined effects of soil liquefaction and Tsunami. With the effective stress analyses, this study demonstrates the importance of the combined effects of soil liquefaction at pile foundations in addition to the external force of Tsunami.