論文

国際誌
2021年8月20日

Association of maternal total cholesterol with SGA or LGA birth at term: The Japan Environment and Children's Study.

The Journal of clinical endocrinology and metabolism
  • Kayo Kaneko
  • Yuki Ito
  • Takeshi Ebara
  • Sayaka Kato
  • Taro Matsuki
  • Hazuki Tamada
  • Hirotaka Sato
  • Shinji Saitoh
  • Mayumi Sugiura-Ogasawara
  • Shin Yamazaki
  • Yukihiro Ohya
  • Reiko Kishi
  • Nobuo Yaegashi
  • Koichi Hashimoto
  • Chisato Mori
  • Shuichi Ito
  • Zentaro Yamagata
  • Hidekuni Inadera
  • Takeo Nakayama
  • Hiroyasu Iso
  • Masayuki Shima
  • Youichi Kurozawa
  • Narufumi Suganuma
  • Koichi Kusuhara
  • Takahiko Katoh
  • Michihiro Kamijima
  • 全て表示

107
1
開始ページ
e118-e129
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1210/clinem/dgab618

CONTEXT: Maternal cholesterol is important for fetal development. Whether maternal serum total cholesterol (maternal TC) levels in mid-pregnancy are associated with small- (SGA) or large- (LGA) for-gestational-age independent of pre-pregnancy body mass index (BMI) and weight gain during pregnancy is inconclusive. OBJECTIVE: To prospectively investigate the association between maternal TC in mid-pregnancy and SGA or LGA. DESIGN AND SETTING: The Japan Environment and Children's Study is a nationwide prospective birth cohort study in Japan. PARTICIPANTS: A total of 37,449 non-diabetic, non-hypertensive mothers with singleton birth at term without congenital abnormalities. OUTCOME MEASURES: Birth weight for the gestational age <10 percentile and ≥90 percentile were respectively defined as SGA and LGA by the Japanese neonatal anthropometric charts. RESULTS: The mean gestational age at blood sampling was 22.7±4.0 weeks. After adjustment for maternal age, sex of child, parity, weight gain during pregnancy, pre-pregnancy BMI, smoking, alcohol drinking, blood glucose levels, household income, and Study Areas, one standard deviation decrement of maternal TC was linearly associated with SGA [odds ratio (OR): 95% confidence intervals (CI) = 1.20: 1.15-1.25]. In contrast, one standard deviation increment of maternal TC was linearly associated with LGA [OR: 95% CI = 1.13: 1.09-1.16]. Associations did not differ according to pre-pregnancy BMI and gestational weight gain (p for interaction>0.20). CONCLUSION: Maternal TC levels in mid-pregnancy were associated with SGA or LGA in Japanese. Maternal TC in mid-pregnancy may help to predict SGA and LGA. Favorable maternal lipid profiles for fetal development must be explored.

リンク情報
DOI
https://doi.org/10.1210/clinem/dgab618
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34416000
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684489
ID情報
  • DOI : 10.1210/clinem/dgab618
  • PubMed ID : 34416000
  • PubMed Central 記事ID : PMC8684489

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