Tomoaki Nagai

Profile Information

Affiliation: Assistant Professor, School of Medicine (Life Sciences and Social Medicine) Department of Biochemistry, Fukushima Medical University

Degree: 博士 (生命科学)(東北大学)

J-GLOBAL ID: 201501020664018486
researchmap Member ID: 7000012558

External link: http://db.tohoku.ac.jp/whois/e_detail/acb7a12bedad294a8b16f59bfab9edbf.html

Research Interests

Research Areas

Life sciences / Cell biology /

Education

Apr, 2010 - Jul, 2013

Tohoku University
Apr, 2004 - Mar, 2008

Faculty of Science, Tohoku University

Papers

Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.

Takashi Yamazoe, Tomoaki Nagai, Shinya Umeda, Yuko Sugaya, Kensaku Mizuno

The Journal of biological chemistry, Aug 20, 2020 Peer-reviewed
Tactics of cancer invasion: solitary and collective invasion(和訳中)

Nagai Tomoaki, Ishikawa Tomohiro, Minami Yasuhiro, Nishita Michiru

The Journal of Biochemistry, 167(4) 347-355, Apr, 2020 Peer-reviewed
Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP

Irie, K., Nagai, T., Mizuno, K.

J. Biol. Chem., 295 3017-3028, Mar 6, 2020 Peer-reviewed
Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.

Daiki X Sato, Yuu Ishii, Tomoaki Nagai, Kazumasa Ohashi, Masakado Kawata

BMC evolutionary biology, 19(1) 220-220, Dec 2, 2019 Peer-reviewed
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K

Journal of cell science, 131(24), Dec, 2018 Peer-reviewed
Glucose deprivation induces primary cilium formation through mTORC1 inactivation

Kengo Takahashi, Tomoaki Nagai, Shuhei Chiba, Keiko Nakayama, Kensaku Mizuno

Journal of Cell Science, 131(1), Jan 1, 2018 Peer-reviewed
Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation

Tomoaki Nagai, Kensaku Mizuno

PLOS ONE, 12(8) e0183030, Aug, 2017 Peer-reviewed
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis

Shoko Abe, Tomoaki Nagai, Moe Masukawa, Kanji Okumoto, Yuta Homma, Yukio Fujiki, Kensaku Mizuno

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(10) 4089-4098, Mar, 2017 Peer-reviewed
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis

Shoko Abe, Tomoaki Nagai, Moe Masukawa, Kanji Okumoto, Yuta Homma, Yukio Fujiki, Kensaku Mizuno

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(10) 4089-4098, Mar, 2017 Peer-reviewed
A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1

Katsunori Takahashi, Haruka Okabe, Shin-ichiro Kanno, Tomoaki Nagai, Kensaku Mizuno

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 482(4) 686-692, Jan, 2017 Peer-reviewed
Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization

Gleb Konotop, Elena Bausch, Tomoaki Nagai, Andrey Turchinovich, Natalia Becker, Axel Benner, Michael Boutros, Kensaku Mizuno, Alwin Kraemer, Marc Steffen Raab

CANCER RESEARCH, 76(22) 6690-6700, Nov, 2016 Peer-reviewed
Cep164, but not EB1, is critical for centriolar localization of TTBK2 and its function in ciliogenesis

Toshiaki Oda, Shuhei Chiba, Tomoaki Nagai, Kensaku Mizuno

Cilia, (1), Jul 13, 2015 Peer-reviewed
Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis

Toshiaki Oda, Shuhei Chiba, Tomoaki Nagai, Kensaku Mizuno

GENES TO CELLS, 19(12) 927-940, Dec, 2014 Peer-reviewed
Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase

Tomoaki Nagai, Masanori Ikeda, Shuhei Chiba, Shin-ichiro Kanno, Kensaku Mizuno

JOURNAL OF CELL SCIENCE, 126(19) 4369-4380, Oct, 2013 Peer-reviewed
微小管結合蛋白質Furryによる微小管アセチル化制御機構

永井友朗, 千葉秀平, 池田真教, 菅野新一郎, 水野健作

生化学, 84(6) 507-507, Jun, 2012
Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension

Tai Kiuchi, Tomoaki Nagai, Kazumasa Ohashi, Kensaku Mizuno

JOURNAL OF CELL BIOLOGY, 193(2) 365-380, Apr, 2011 Peer-reviewed
Analysis of the regulation of actin cytoskeleton dynamics using dronpa, a photochromic fluorescent protein

Kazumasa Ohashi, Tai Kiuchi, Tomoaki Nagai, Kensaku Mizuno

2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, 317-322, 2008 Peer-reviewed

Misc.

【タンパク質・核酸の分子修飾】細胞質/オルガネラでの分子修飾微小管アセチル化,脱アセチル化

永井友朗, 水野健作

生体の科学, 69(5) 484-485, Oct, 2018
【広がるHippo pathway研究-癌から各種疾患へ】基礎編哺乳類NDRキナーゼの細胞機能もうひとつのHippo下流キナーゼ

永井友朗, 水野健作

医学のあゆみ, 251(5) 365-370, Nov, 2014
【広がるHippo pathway研究-癌から各種疾患へ】基礎編哺乳類NDRキナーゼの細胞機能もうひとつのHippo下流キナーゼ

永井友朗, 水野健作

医学のあゆみ, 251(5) 365-370, Nov, 2014
Multifaceted roles of Furry proteins in invertebrates and vertebrates

Tomoaki Nagai, Kensaku Mizuno

JOURNAL OF BIOCHEMISTRY, 155(3) 137-146, Mar, 2014
TTBK2はCep164と結合することで中心体に局在し,一次繊毛形成を促進する

小田聡明, 千葉秀平, 永井友朗, 水野健作

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
Furryによるチューブリン脱アセチル化酵素SIRT2の活性制御と分裂期紡錘体微小管のアセチル化に対する役割

永井友朗, 池田真教, 千葉秀平, 菅野新一郎, 水野健作

日本分子生物学会年会プログラム・要旨集(Web), 36th, 2013
Live-cell imaging of G-actin dynamics using sequential FDAP.

Tai Kiuchi, Tomoaki Nagai, Kazumasa Ohashi, Naoki Watanabe, Kensaku Mizuno

BioArchitecture, 1 240-244, 2011

Presentations

マイクロパターニング技術を用いた上皮細胞の極性形成機構の解析

永井友朗

日仏生物学会第193会例会, Dec 5, 2020
Jasplakinolide-induced cell rounding inactivates YAP protein and induces ciliogenesis

Kensaku Mizuno

第68回日本細胞生物学会, Jun 15, 2016
Jasplakinolide-induced cell rounding provokes primary ciliogenesis

Kengo Takahashi, Sachiho Mukouyama, Kensaku Mizuno

第38回分子生物学会年会・第88回生化学会大会, Dec 1, 2015

Teaching Experience

Research Projects

一次繊毛先端部におけるアンテナ機能制御と繊毛病発症の分子機構

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

永井友朗
Mechanisms of growth arrest-induced TTBK2 activation and its role for ciliogenesis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Nagai Tomoaki
Functional analysis of microtubule-binding protein, Furry, in the formation of mitotic spindle and recessive mental retardation

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Nagai Tomoaki
Dronpaを用いたライブイメージングによる細胞内G－アクチン濃度の時空間的測定

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2011 - 2012

永井友朗

Profile Information

Research Interests

Research Areas

Education

Papers

Misc.

Presentations

Teaching Experience

Research Projects

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