2010年12月
Anti-GM1 antibodies affect the integrity of lipid rafts
MOLECULAR AND CELLULAR NEUROSCIENCE
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- 巻
- 45
- 号
- 4
- 開始ページ
- 355
- 終了ページ
- 362
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.mcn.2010.07.008
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Previous studies have shown that patients with the axonal form of Guillain-Barre syndrome (CBS) develop autoantibodies against GM1 ganglioside (GM1) Nerve growth factor (NGF) is essential for neuronal survival in vivo and its functional receptor is Trk-tyrosine kinase Here we examined the biological effects of sera from patients with the axonal form of GBS on the morphology and the phosphorylation state of Trk-tyrosine kinase in PC12 cells Furthermore we examined the effect of the sera on the integrity of membrane lipid rafts biochemically The data show that anti GM1 antibodies found in patients sera but not control sera inhibit NGF-induced Trk autophosphorylation Most intriguingly the autoantibodies alter the distribution of Trk in lipid rafts without shifting the distribution of a rafts marker protein These data strongly suggest that anti GM1 antibodies directly influence the integrity of the signaling platform lipid rafts implicating the importance of lipid rafts in the development of this disorder (C) 2010 Elsevier Inc All rights reserved
- リンク情報
- ID情報
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- DOI : 10.1016/j.mcn.2010.07.008
- ISSN : 1044-7431
- eISSN : 1095-9327
- PubMed ID : 20659560
- Web of Science ID : WOS:000283970100005