論文

査読有り
2017年6月

Usefulness of combining I-123-FP-CIT-SPECT striatal asymmetry index and cardiac I-123-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms

JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Yoshiki Niimi
  • ,
  • Shinji Ito
  • ,
  • Kenichiro Murate
  • ,
  • Seiko Hirota
  • ,
  • Chika Hikichi
  • ,
  • Tomomasa Ishikawa
  • ,
  • Toshiki Maeda
  • ,
  • Ryunosuke Nagao
  • ,
  • Sayuri Shima
  • ,
  • Yasuaki Mizutani
  • ,
  • Akihiro Ueda
  • ,
  • Tatsuro Mutoh

377
開始ページ
174
終了ページ
178
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jns.2017.04.026
出版者・発行元
ELSEVIER SCIENCE BV

Background: Although single-photon emission computerized tomography of the dopamine transporter (DATSPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown.
Methods: We enrolled 32 patients showing parkinsonism with normal cardiac I-123-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations.
Results: The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p < 0.05), but there were no differences in the specific binding ratios between the two groups.
Conclusion: The combined use of striatal asymmetry index on DAT-SPEC' and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes. (C) 2017 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1016/j.jns.2017.04.026
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28477690
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401879000035&DestApp=WOS_CPL

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