論文

査読有り
2016年9月

Differentiation of cancer from atrial fibrillation in patients with acute multifocal stroke

JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Shinji Ito
  • ,
  • Akihiro Ueda
  • ,
  • Kenichiro Murate
  • ,
  • Seiko Hirota
  • ,
  • Takao Fukui
  • ,
  • Tomomasa Ishikawa
  • ,
  • Sayuri Shima
  • ,
  • Chika Hikichi
  • ,
  • Yasuaki Mizutani
  • ,
  • Madoka Kizawa
  • ,
  • Kunihiko Asakura
  • ,
  • Tatsuro Mutoh

368
開始ページ
344
終了ページ
348
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jns.2016.07.054
出版者・発行元
ELSEVIER SCIENCE BV

Objective: Acute multifocal embolic infarction (AMEI) is conventionally caused by etiologies such as cardioembolism due to atrial fibrillation (AO, but can also be caused by serious underlying diseases such as cancer. We characterized cancer-related AMEI and identified useful indicators for cancer-associated strokes.
Methods: A retrospective analysis was performed on 35 patients with Af-related AMEI and 35 patients with cancer -related AMEI selected from 1235 consecutive patients with acute infarcts. All patients received diffusion weighted magnetic resonance (MR) imaging. Cerebral MR angiography, carotid and cardiac ultrasonography, electrocardiogram-monitoring and whole body computed tomography were also performed on these patients. D-dimer levels were evaluated on admission, and were measured during the sub-acute phase in 19 of the patients with Af and 27 of the patients with cancer.
Results: Acute phase D-dimer levels were significantly higher in patients with cancer than in patients with Af alone. The cut-off D-dimer value to identify cancer-associated infarcts was 2.0 mu g/mL. D-dimer levels during the sub-acute phase remained elevated in the cancer patients.
Conclusions: We may differentiate cancer-associated AMEI from Af using a D-dimer level >= 2.0 mu g/mL, which does not decrease during the sub-acute phase. (C) 2016 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1016/j.jns.2016.07.054
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382415700071&DestApp=WOS_CPL

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