論文

査読有り
2015年12月

Retrospective analysis of parkinsonian patients exhibiting normal I-123-MIBG cardiac uptake

JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Yasuaki Mizutani
  • ,
  • Shinji Ito
  • ,
  • Kenichiro Murate
  • ,
  • Seiko Hirota
  • ,
  • Takao Fukui
  • ,
  • Chika Hikichi
  • ,
  • Tomomasa Ishikawa
  • ,
  • Sayuri Shima
  • ,
  • Aldhiro Ueda
  • ,
  • Madoka Kizawa
  • ,
  • Kunihiko Asakura
  • ,
  • Tatsuro Mutoh

359
1-2
開始ページ
236
終了ページ
240
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jns.2015.10.059
出版者・発行元
ELSEVIER SCIENCE BV

Background: Although most patients with Parkinson's disease (PD) show decreased cardiac I-123-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients.
Methods: We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 +/- 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated >= 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N = 37) and other groups (N = 117).
Results: The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG HIM ratio in the delayed phase (delayed, p < 0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p < 0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods.
Conclusions: An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients. (C) 2015 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/j.jns.2015.10.059
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000367276200045&DestApp=WOS_CPL

エクスポート
BibTeX RIS