論文

国際誌
2021年8月5日

Genome-wide association study reveals an association between the HLA-DPB1∗02:01:02 allele and wheat-dependent exercise-induced anaphylaxis.

American journal of human genetics
  • Koya Fukunaga
  • ,
  • Yuko Chinuki
  • ,
  • Yuto Hamada
  • ,
  • Yuma Fukutomi
  • ,
  • Akiko Sugiyama
  • ,
  • Reiko Kishikawa
  • ,
  • Atsushi Fukunaga
  • ,
  • Yoshiko Oda
  • ,
  • Tsukasa Ugajin
  • ,
  • Hiroo Yokozeki
  • ,
  • Naoe Harada
  • ,
  • Masataka Suehiro
  • ,
  • Michihiro Hide
  • ,
  • Yukinobu Nakagawa
  • ,
  • Emiko Noguchi
  • ,
  • Masashi Nakamura
  • ,
  • Kayoko Matsunaga
  • ,
  • Akiko Yagami
  • ,
  • Eishin Morita
  • ,
  • Taisei Mushiroda

108
8
開始ページ
1540
終了ページ
1548
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ajhg.2021.06.017

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a life-threatening food allergy triggered by wheat in combination with the second factor such as exercise. The identification of potential genetic risk factors for this allergy might help high-risk individuals before consuming wheat-containing food. We aimed to identify genetic variants associated with WDEIA. A genome-wide association study was conducted in a discovery set of 77 individuals with WDEIA and 924 control subjects via three genetic models. The associations were confirmed in a replication set of 91 affected individuals and 435 control individuals. Summary statistics from the combined set were analyzed by meta-analysis with a random-effect model. In the discovery set, a locus on chromosome 6, rs9277630, was associated with WDEIA in the dominant model (OR = 3.95 [95% CI, 2.31-6.73], p = 7.87 × 10-8). The HLA-DPB1∗02:01:02 allele displayed the most significant association with WDEIA (OR = 4.51 [95% CI, 2.66-7.63], p = 2.28 × 10-9), as determined via HLA imputation following targeted sequencing. The association of the allele with WDEIA was confirmed in replication samples (OR = 3.82 [95% CI, 2.33-6.26], p = 3.03 × 10-8). A meta-analysis performed in the combined set revealed that the HLA-DPB1∗02:01:02 allele was significantly associated with an increased risk of WDEIA (OR = 4.13 [95% CI, 2.89-5.93], p = 1.06 × 10-14). Individuals carrying the HLA-DPB1∗02:01:02 allele have a significantly increased risk of WDEIA. Further validation of these findings in independent multiethnic cohorts is needed.

リンク情報
DOI
https://doi.org/10.1016/j.ajhg.2021.06.017
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34246321
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387458
ID情報
  • DOI : 10.1016/j.ajhg.2021.06.017
  • PubMed ID : 34246321
  • PubMed Central 記事ID : PMC8387458

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