2014年
DPCデータを用いたMRSA感染症患者におけるTDMの臨床評価
医薬品情報学
- ,
- ,
- 巻
- 15
- 号
- 4
- 開始ページ
- 19
- 終了ページ
- 22
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.11256/jjdi.15.165
- 出版者・発行元
- 一般社団法人 日本医薬品情報学会
Objective: The purpose of this study was to clarify the importance of therapeutic drug monitoring (TDM) at acute care hospitals using Diagnosis Procedure Combination (DPC) data.<br>Methods: We used DPC data from about 3,500,000 inpatients at about 950 acute care hospitals. The investigation period was from July 2010 to December 2010. Patients were divided into 2 groups: TDM intervention (n=22,012); and non-TDM intervention (n=26,400). We compared the clinical indicators (length of hospital stay, payment based on performance and drug costs) and use of antimicrobials.<br>Results: TDM intervention was carried out in 45.5% patients for whom an anti-MRSA agent was prescribed. The duration of anti-MRSA agent administration was significantly longer in the TDM intervention group than in the non-TDM intervention group. The total daily cost of anti-MRSA agents was significantly lower in the TDM intervention group than in the non-TDM intervention group.<br>Conclusion: Our results suggest that TDM intervention is often performed for seriously ill patients who require continuous treatment. TDM intervention may prevent adverse reactions as a result of adjusting the dosage of the anti-MRSA agent.
- リンク情報
- ID情報
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- DOI : 10.11256/jjdi.15.165
- ISSN : 1345-1464
- CiNii Articles ID : 130004941475