論文

査読有り
2016年5月

Azapirones for Attention Deficit Hyperactivity Disorder: A Systematic Review

PHARMACOPSYCHIATRY
  • Y. Matsui
  • ,
  • S. Matsunaga
  • ,
  • Y. Matsuda
  • ,
  • T. Kishi
  • ,
  • N. Iwata

49
3
開始ページ
97
終了ページ
106
記述言語
英語
掲載種別
DOI
10.1055/s-0042-102457
出版者・発行元
GEORG THIEME VERLAG KG

Introduction: No meta-analysis has evaluated azapirones (serotonin(1A) receptor partial agonists) as anxiolytics for attention deficit hyperactivity disorder (ADHD).
Methods: Randomized controlled trials (RCTs) and single-arm trials published before October 27, 2015 were retrieved from major healthcare databases and clinical trial registries. Relative risk and 95 % confidence intervals were calculated.
Results: 5 RCTs (n = 429) and 3 single-arm studies (n = 70) were identified. 3 RCTs compared buspirone vs. methylphenidate in children/adolescents, one buspirone patches vs. placebo patches in children/adolescents, and one atomoxetine plus buspirone vs. atomoxetine vs. placebo in adults. The single-arm studies were buspirone trails in children/adolescents. All-cause discontinuation rates and adverse events did not differ between pooled buspirone and methylphenidate groups. No other meta-analyses of buspirone efficacy and safety vs. comparators were conducted due to insufficient data. 2 RCTs found no significant differences in parent and teacher ADHD-Rating Scale total scores between buspirone and methylphenidate, while one reported that methylphenidate improved parent and teacher ADHD-RS total scores vs. buspirone.
Discussion: It remains unclear whether buspirone use has benefit for ADHD patients and therefore further evidence is needed for better clinical use of buspirone in patients with ADHD.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1055/s-0042-102457
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000376659400002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1055/s-0042-102457
  • ISSN : 0176-3679
  • eISSN : 1439-0795
  • Web of Science ID : WOS:000376659400002

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