Ryota Shinohara

Profile Information

Affiliation: Associate Professor, Graduate School of Medicine, Kobe University

Degree: Ph.D.(Mar, 2012, Kyoto University)

ORCID ID: https://orcid.org/0000-0001-5279-2642
J-GLOBAL ID: 201501020103927029
researchmap Member ID: 7000013814

Research Areas

Research History

Jul, 2021 - Present

Associate Professor, Graduate School of Medicine, Kobe University
Apr, 2021 - Jun, 2021

Associate Professor, Graduate School of Medicine, Kobe University
Sep, 2019 - Mar, 2021

Associate Research Scientist, Department of Psychiatry, Yale University School of Medicine
Sep, 2017 - Aug, 2019

Postdoctoral Fellow, Department of Psychiatry, Yale University School of Medicine
Oct, 2016 - Sep, 2017

Assistant Professor, Graduate School of Medicine, Kobe University
Sep, 2015 - Sep, 2016

Research Assistant Professor, Graduate School of Medicine, Kobe University
Apr, 2013 - Aug, 2015

Research Fellowship for Young Scientists (PD), Japan Society for the Promotion of Science
Apr, 2012 - Mar, 2013

Postdoctoral Fellow, Graduate School of Medicine, Kyoto University
Apr, 2010 - Mar, 2012

Research Fellowship for Young Scientists (DC2), Japan Society for the Promotion of Science

Education

Apr, 2008 - Mar, 2012

Kyoto University Graduate School of Medicine

Awards

Nov, 2022

Young Investigator Award, Study on mechanisms and pathophysiological significance of neural circuit formation and plasticity, The Japanese Society of Neuropsychopharmacology
Jun, 2022

令和４年度優秀若手研究者賞, 国立大学法人神戸大学

篠原亮太
Mar, 2022

Young Investigator Award, Elucidation of mechanisms and pathophysiological significance of neural circuit formation and plasticity, The Japanese Pharmacological Society
Sep, 2017

Japan-U.S. Brain Research Cooperation Program, National Institute for Physiological Sciences

Ryota Shinohara
Sep, 2017

Research Fellowship, The Uehara Memorial Foundation

Ryota Shinohara
Feb, 2013

29th Inoue Research Award for Young Scientists, Inoue Foundation for Science

Ryota Shinohara
Apr, 2008

Scholarship, Iwadare Scholarship Foundation

Papers

Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice

Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki

Scientific Reports, 12(1) 11385-11385, Jul, 2022 Peer-reviewed
Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities

Ryota Shinohara, George K. Aghajanian, Chadi G. Abdallah

Biological Psychiatry, Dec, 2020 Peer-reviewedInvitedLead author
Cell-type specific modulation of NMDA receptors triggers antidepressant actions

Santosh Pothula, Taro Kato, Rong-Jian Liu, Min Wu, Danielle Gerhard, Ryota Shinohara, Alexa-Nicole Sliby, Golam M. I. Chowdhury, Kevin L. Behar, Gerard Sanacora, Pradeep Banerjee, Ronald S. Duman

Molecular Psychiatry, Jun 2, 2020 Peer-reviewed
Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function

Ronald S. Duman, Ryota Shinohara, Manoela V. Fogaça, Brendan Hare

Molecular Psychiatry, 24(12) 1816-1832, Dec, 2019 Peer-reviewedInvited
Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex

Chisato Numa, Hirotaka Nagai, Masayuki Taniguchi, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki

Scientific Reports, 9(1), Nov, 2019 Peer-reviewed
Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice

Satoshi Okamura, Hirotaka Nagai, Chisato Numa, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki

Neuropsychopharmacology Reports, 39(2) 134-139, Jun, 2019 Peer-reviewed
Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Brendan D. Hare, Ryota Shinohara, Rong Jian Liu, Santosh Pothula, Ralph J. DiLeone, Ronald S. Duman

Nature Communications, 10(1), Jan, 2019 Peer-reviewed
Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety

Shu Higashida, Hirotaka Nagai, Kazuki Nakayama, Ryota Shinohara, Masayuki Taniguchi, Midori Nagai, Takatoshi Hikida, Satoshi Yawata, Yukio Ago, Shiho Kitaoka, Shuh Narumiya, Tomoyuki Furuyashiki

Scientific Reports, 8(1), Dec, 2018 Peer-reviewedLead author
Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

R Shinohara, M Taniguchi, A T Ehrlich, K Yokogawa, Y Deguchi, Y Cherasse, M Lazarus, Y Urade, A Ogawa, S Kitaoka, A Sawa, S Narumiya, T Furuyashiki

Molecular Psychiatry, 23(8) 1717-1730, Aug, 2018 Peer-reviewedLead author
Characterization of a novel rhamnose-containing acidic glycosphingolipid from the ascidian Halocynthia aurantium

Hisao Kojima, Ryota Shinohara, Saki Itonori, Masahiro Ito

Journal of Oleo Science, 66(3) 285-295, 2017 Peer-reviewedLead author
mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety

Yuichi Deguchi, Masaya Harada, Ryota Shinohara, Michael Lazarus, Yoan Cherasse, Yoshihiro Urade, Daisuke Yamada, Masayuki Sekiguchi, Dai Watanabe, Tomoyuki Furuyashiki, Shuh Narumiya

Cell Reports, 17(9) 2405-2417, Nov 22, 2016 Peer-reviewed
The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice

Tetsushi Hirano, Shogo Yanai, Takuya Omotehara, Rie Hashimoto, Yuria Umemura, Naoto Kubota, Kiichi Minami, Daichi Nagahara, Eiko Matsuo, Yoshiko Aihara, Ryota Shinohara, Tomoyuki Furuyashiki, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi

Journal of Veterinary Medical Science, 77(10) 1207-1215, Nov 5, 2015 Peer-reviewed
EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.

Yosuke Toyoda, Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Hiroshi Nishimaru, Hiroyuki Hioki, Takeshi Kaneko, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya

Genes to cells : devoted to molecular & cellular mechanisms, 18(10) 873-85, Oct, 2013 Peer-reviewedLead author
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Naoko Kaneko, Kazunobu Sawamoto, Keisuke Watanabe, Hirohide Takebayashi, Hiroshi Kiyonari, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya

Nature Neuroscience, 15(3) 373-380, Mar, 2012 Peer-reviewedLead author
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia

Dean Thumkeo, Ryota Shinohara, Keisuke Watanabe, Hirohide Takebayashi, Yosuke Toyoda, Kiyoshi Tohyama, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya

PLoS ONE, 6(9) e25465-e25465, Sep 28, 2011 Peer-reviewedLead author
Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava

Masahiro Ito, Kazuhito Yokoi, Takashi Inoue, Shogo Asano, Rei Hatano, Ryota Shinohara, Saki Itonori, Mutsumi Sugita

Journal of Oleo Science, 58(9) 473-480, Aug 5, 2009 Peer-reviewed

Misc.

Roles of the dopaminergic system in the medial prefrontal cortex for stress resilience and its relevance to stress-induced changes in neuronal morphology

TANIGUCHI, Masayuki, SHINOHARA, Ryota, FURUYASHIKI, Tomoyuki

Japanese Journal of Biological Psychiatry, 29(1) 27-33, 2018 Peer-reviewedInvited
Neural circuits regulating stress resilience

SHINOHARA, Ryota

Nihon Yakurigaku Zasshi, 150(5) 261-261, Nov, 2017 Peer-reviewedInvitedLead authorCorresponding author
Roles of dopaminergic and inflammation-related molecular derived from microglia in stress-induced behavioral changes

SHINOHARA Ryota, KITAOKA Shiho, FURUYASHIKI Tomoyuki

PAIN RESEARCH, 31(1号) 1-8, Mar, 2016 Peer-reviewedInvitedLead author
輝け次代の担い手たち神経発生におけるRho標的アクチン重合因子mDiaの役割

SHINOHARA Ryota

神経化学, 52(1号) 13-21, Mar, 2013 InvitedLead authorCorresponding author
Rho依存的アクチン重合因子mDiaはephrinによる軸索成長円錐の退縮に重要である(mDia, a Rho effector and actin nucleator, is critical for growth cone retraction in ephrin-induced axonal repulsion)

豊田洋輔, 篠原亮太, タムケオ・ディーン, 上條博史, 日置寛之, 金子武嗣, 石崎敏理, 古屋敷智之, 成宮周

日本生化学会大会プログラム・講演要旨集, 84回 3P-0588, Sep, 2011

Presentations

A neural circuit mechanism underlying rapid antidepressant actions of ketamine

Ryota Shinohara, Brendan D Hare, Rong-Jian Liu, Jin Hua Li, Xiao-Yuan Li, Catharine H Duman, Ralph J DiLeone, Ronald S Duman

The 44th Annual Meeting of the Japan Neuroscience Society / The 1st CJK International Meeting, Jul 29, 2021
Distinct projection targets of dopamine D1 receptor-expressing neurons in the prefrontal cortex underlying antidepressant responses to ketamine

Ryota Shinohara, Brendan D. Hare, Rong-Jian Liu, Jin Hua, Li, Xiao-Yuan Li, Catharine H. Duman, Ralph J. DiLeone, Ronald S. Duman

The 43rd Annual Meeting of the Japanese Society of Biological Psychiatry (JSBP) / The 51st Annual Meeting of the Japanese Society of Neuropsychopharmacology (JSNP), Jul 16, 2021
Distinct projections of the medial prefrontal cortex underlie the rapid antidepressant actions of ketamine

Shinohara, R., Hare, B.D., Liu, R.J., Duman, R.S.

Neuroscience 2019, Oct 22, 2019, Society for Neuroscience
Dissecting neural circuits underlying stress and rapid antidepressant actions in animal models

Ryota Shinohara

Biological Sciences Training Program (BSTP) Seminar Series, Sep 23, 2019, Department of Psychiatry, Yale University School of Medicine Invited
Identifying the molecular and neural circuit mechanisms of the action of rapid-acting antidepressants

SHINOHARA, Ryota

The 42nd Annual Meeting of the Japan Neuroscience Society, Jul 26, 2019 Invited
Projection-specific optogenetic stimulation of medial prefrontal cortex neurons expressing dopamine D1 receptors produces rapid antidepressant effects

Shinohara, R., Hare, B.D., Pothula, S., Duman, R.S.

Neuroscience 2018, Nov 5, 2018, Society for Neuroscience
Dopamine D1 receptor mediates social defeat stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and suppresses stress susceptibility in mice

SHINOHARA Ryota

The 40th Annual Meeting of the Japan Neuroscience Society, Jul, 2017
Dopamine D1 receptor in excitatory neurons in the medial prefrontal cortex suppresses emotional changes induced by social defeat stress

Shinohara Ryota, 谷口将之, 成宮周, Furuyashiki Tomoyuki

The 130th Kinki Regional Meeting of the Japanese Pharmacological Society, Nov, 2016
内側前頭前皮質のドパミン受容体サブタイプによるストレス抵抗性増強と神経回路リモデリング

Shinohara Ryota, 谷口将之, Furuyashiki Tomoyuki

51st Japanese Medical Society of Alcohol and Addiction Studies, Oct, 2016 Invited
A role for prefrontal dopaminergic system in regulating stress resilience

Shinohara Ryota, 谷口将之, エーリックアリザ, 横川賢多朗, 出口雄一, 小川淳史, Kitaoka Shiho, 澤明, 成宮周, Furuyashiki Tomoyuki

46th Annual Meeting of the Japanese Society of Neuropsychopharmacology, Jul, 2016 Invited
Dopamine D1 receptor in the medial prefrontal cortex mediates behavioral resilience under stress in mice

Shinohara Ryota, 谷口将之, エーリックアリザ, 横川賢多朗, 出口雄一, 小川淳史, Kitaoka Shiho, 澤明, 成宮周, Furuyashiki Tomoyuki

CINP 2016 Seoul World Congress (Seoul), Jul, 2016
Dopamine D1 receptor in the medial prefrontal cortex regulates susceptibility to social defeat stress

SHINOHARA RYOTA

The 38th Annual Meeting of the Japan Neuroscience Society, Jul, 2015
A role for dopamine D1 receptor in the medial prefrontal cortex in stress-induced emotional changes

SHINOHARA, Ryota

Ritsumeikan University 6th Symposium of Next Generation Drug Discovery, Mar 30, 2015 Invited
mDia, a Rho-regulated actin nucleator, is critical for tangential migration of inhibitory interneuron precursors

SHINOHARA, Ryota

Kyoto University Global COE Program “Center for Frontier Medicine” International Symposium 2012, Oct 6, 2012 Invited
mDia, an actin nucleator and a Rho effector, is critical for tangential migration of cortical and olfactory bulb inhibitory interneuron precursors

Shinohara, R., Thumkeo, D., Kamijo, H, Kaneko, N., Sawamoto, K., Watanabe, K., Takebayashi, H., Ishizaki, T, Furuyashiki, T., Narumiya, S.

Gordon Research Conference: Mechanisms of Cell Signaling, Aug, 2011

Research Projects

Elucidation of the molecular and neural circuit basis of individual differences in stress resilience

Advanced Research & Development Programs for Medical Innovation (PRIME), Japan Agency for Medical Research and Development (AMED), Oct, 2021 - Mar, 2025

Ryota Shinohara
ドパミン受容体を介した前頭前皮質の神経回路成熟と情動制御での役割

若手研究(B), 日本学術振興会, Apr, 2016 - Mar, 2018

篠原亮太
慢性ストレスによる前頭前皮質の機能変化の分子基盤とその役割

特別研究員奨励費, 日本学術振興会, Apr, 2013 - Mar, 2016

篠原亮太
神経発生におけるRho標的分子mDiaの役割

特別研究員奨励費, 日本学術振興会, Apr, 2010 - Mar, 2012

篠原亮太

Profile Information

Research Areas

Research History

Education

Awards

Papers

Misc.

Presentations

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