2014年5月
Bayesian network meta-analysis suggests a similar effectiveness between a monovalent and a pentavalent rotavirus vaccine A preliminary report of re-analyses of data from a Cochrane Database Systematic Review
HUMAN VACCINES & IMMUNOTHERAPEUTICS
- 巻
- 10
- 号
- 5
- 開始ページ
- 1421
- 終了ページ
- 1424
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4161/hv.28284
- 出版者・発行元
- LANDES BIOSCIENCE
To assess the comparative effectiveness of a monovalent and a pentavalent rotavirus vaccine (RV1 and RV5), a Bayesian network meta-analysis was conducted. Data of randomized trials from the Cochrane Review in 2012 were extracted and synthesized. For the prevention of severe rotavirus disease up to 2 years, no statistical difference was found in the effectiveness between the 2 types of vaccine (odds ratio: 2.23, 95% credible interval: 0.71-5.20). Similarly, the comparative effectiveness of RV1 and RV5 appeared equivalent for other rotavirus-associated outcome measures, such as prevention of severe disease up to 1 year and all severity of rotavirus infections for up to both 1- and 2-year follow-ups. These results indicates that, overall, RV1 and RV5 offer similar benefits to prevent rotavirus diseases; nonetheless, credible intervals are generally wide, highlighting the necessity of further meta-analyses including updated information or, ideally, controlled trials comparing both vaccines directly.
- リンク情報
- ID情報
-
- DOI : 10.4161/hv.28284
- ISSN : 2164-5515
- eISSN : 2164-554X
- PubMed ID : 24608099
- Web of Science ID : WOS:000336656700049