Ko, Minoru

J-GLOBAL         Last updated: May 29, 2019 at 02:55
 
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Name
Ko, Minoru
E-mail
ko.minorukeio.jp
URL
http://systemsmedicine.jp
Affiliation
Keio University
Section
School of Medicine The Sakaguchi Laboratory - Department of Systems Medicine
Job title
Professor (Non-tenured)
Degree
医学博士(Keio University)
Research funding number
50631199

Academic & Professional Experience

 
Apr 1988
 - 
Jul 1991
研究員, 古澤発生遺伝子プロジェクト、遺伝子発現グループ, 科学技術庁(旧)、新技術事業団、創造科学推進事業
 
Aug 1991
 - 
Aug 1992
グループリーダー, 古澤発生遺伝子プロジェクト、遺伝子発現グループ, 科学技術庁(旧)、新技術事業団、創造科学推進事業
 
Sep 1992
 - 
Aug 1997
助教授, 分子医学遺伝学センター, 米国ミシガン州立ウェインステイト大学、医学部
 
Sep 1997
 - 
Aug 1998
准教授(終身在職権), 分子医学遺伝学センター、内科学教室, 米国ミシガン州立ウェインステイト大学、医学部、
 
Sep 1998
 - 
Dec 2011
主任研究員(終身在職権)、部門長, 発生老化ゲノム学部門, 米国国立衛生研究所、国立老化研究所
 

Education

 
Apr 1980
 - 
Mar 1986
School of Medicine, Keio University
 
Apr 1986
 - 
Mar 1988
医学研究科, Keio University
 

Published Papers

 
Matsumoto Hirotaka, Kiryu Hisanori, Furusawa Chikara, Ko Minoru S.H., Ko Shigeru B.H., Gouda Norio, Hayashi Tetsutaro, Nikaido Itoshi
Bioinformatics   33(15) 2314-2321   Aug 2017
<p>Motivation: The analysis of RNA-Seq data from individual differentiating cells enables us to reconstruct the differentiation process and the degree of differentiation (in pseudo-time) of each cell. Such analyses can reveal detailed expression d...
Matsushita Misako, Nakatake Yuhki, Arai Itaru, Ibata Keiji, Kohda Kazuhisa, Goparaju Sravan K., Murakami Miyako, Sakota Miki, Chikazawa-Nohtomi Nana, Ko Shigeru B.H., Kanai Takanori, Yuzaki Michisuke, Ko Minoru S.H.
Biochemical and Biophysical Research Communications      May 2017
<p>Pluripotent human embryonic stem cells (hESCs) can differentiate into multiple cell lineages, thus, providing one of the best platforms to study molecular mechanisms during cell differentiation. Recently, we have reported rapid and efficient di...
Goparaju Sravan Kumar, Kohda Kazuhisa, Ibata Keiji, Soma Atsumi, Nakatake Yukhi, Akiyama Tomohiko, Wakabayashi Shunichi, Matsushita Misako, Sakota Miki, Kimura Hiromi, Yuzaki Michisuke, Ko Shigeru B H, Ko Minoru S H
Scientific Reports   7    Feb 2017
<p>Efficient differentiation of human pluripotent stem cells (hPSCs) into neurons is paramount for disease modeling, drug screening, and cell transplantation therapy in regenerative medicine. In this manuscript, we report the capability of five tr...
Akiyama Tomohiko, Wakabayashi Shunichi, Soma Atsumi, Sato Saeko, Nakatake Yuhki, Oda Mayumi, Murakami Miyako, Sakota Miki, Chikazawa-Nohtomi Nana, Ko Shigeru B.H., Ko Minoru S.H.
Stem Cells International   2017    2017
<p>Human pluripotent stem cells (hPSCs) have the capacity to differentiate into essentially all cell types in the body. Such differentiation can be directed to specific cell types by appropriate cell culture conditions or overexpressing lineage-de...
Akiyama Tomohiko, Wakabayashi Shunichi, Soma Atsumi, Sato Saeko, Nakatake Yuhki, Oda Mayumi, Murakami Miyako, Sakota Miki, Chikazawa-Nohtomi Nana, Ko Shigeru B H, Ko Minoru S H
Development (Cambridge)   143(20) 3674-3685   Oct 2016
<p>Harnessing epigenetic regulation is crucial for the efficient and proper differentiation of pluripotent stem cells (PSCs) into desired cell types. Histone H3 lysine 27 trimethylation (H3K27me3) functions as a barrier against cell differentiatio...

Books etc

 
Harrison's Principles of Internal Medicine, 19th Edition
Ko Minoru (Part:Contributor, Stem Cell Biology)
McGraw-Hill   2015   
Harrison's Principles of Internal Medicine, 18th Edition
Ko Minoru (Part:Contributor, Stem Cell Biology)
McGraw-Hill   2011   
Harrison's Principles of Internal Medicine, 17th Edition
Ko Minoru (Part:Contributor, Stem Cell Biology)
McGraw-Hill   2008   
Human Pluripotent Stem Cells
Ko Minoru (Part:Contributor, Genomic approaches to stem cell biology)
BIOS Scientific Publishers   2004   
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
Ko Minoru (Part:Contributor, Principles and Application of Embryogenomics)
WILEY-VCH   2004   

Teaching Experience

 

Research Grants & Projects

 
組織幹細胞の維持・若返りを可能にする新規分子メカニズム
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): 洪 実
Functional analysis of meiosis-related factors in ES cells
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2015 - Mar 2017    Investigator(s): 洪 実
Zscan4 is known to be expressed in the 2 cell stage mouse embryos and is characterized by activation of the zygotic genes and ectopic expression of meiosis-related genes. In this study, ES cells and mice in which GFP was knocked-in at the endogeno...