Kubo Akiko

J-GLOBAL         Last updated: Aug 31, 2017 at 02:51
Kubo Akiko
Keio University
School of Medicine
Job title
Project Senior Assistant Professor / Project Assistant Professor / Project Lecturer
Research funding number

Research Areas


Academic & Professional Experience

Oct 1996
Sep 2001
Researcher, ERATO Tsukita Cell Axis Project, JST
Oct 2001
Mar 2007
研究員, Department of Cell Biology, Kyoto University, School of Medicine
Feb 2007
Mar 2009
研究員, 分子加齢医学, Mitsubishi Institute for Life Sciences
Apr 2009
Project assistant professor, Department of Biochemistry., Keio University, School of Medicine

Published Papers

T. Suhara, T. Hishiki, M. Kasahara, N. Hayakawa, T. Oyaizu, T. Nakanishi, A. Kubo, H. Morisaki, W. G. Kaelin, Jr., M. Suematsu and Y. A. Minamishima
Proceedings of the National Academy of Sciences of the United States of America   112(37) 11642-7   Sep 2015
Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large amounts of lactate to be released from cells into the circulation. We found that Phd2-null mo...
T. Takenouchi, Y. Sugiura, T. Morikawa, T. Nakanishi, Y. Nagahata, T. Sugioka, K. Honda, A. Kubo, T. Hishiki, T. Matsuura, T. Hoshino, T. Takahashi, M. Suematsu and M. Kajimura
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   35(5) 794-805   May 2015
Although therapeutic hypothermia is known to improve neurologic outcomes after perinatal cerebral hypoxia-ischemia, etiology remains unknown. To decipher the mechanisms whereby hypothermia regulates metabolic dynamics in different brain regions, w...
M. Ohmura, T. Hishiki, T. Yamamoto, T. Nakanishi, A. Kubo, K. Tsuchihashi, M. Tamada, S. Toue, Y. Kabe, H. Saya and M. Suematsu
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society   46 102-13   Apr 2015
CD44 expressed in cancer cells was shown to stabilize cystine transporter (xCT) that uptakes cystine and excretes glutamate to supply cysteine as a substrate for reduced glutathione (GSH) for survival. While targeting CD44 serves as a potentially ...
T. Yamamoto, N. Takano, K. Ishiwata, M. Ohmura, Y. Nagahata, T. Matsuura, A. Kamata, K. Sakamoto, T. Nakanishi, A. Kubo, T. Hishiki and M. Suematsu
Nature communications   5 3480   2014
Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we show using metabolomics that CO-sensitive methylation of PFKFB3, an enzyme producing fruct...
S. Yamazoe, M. Naya, M. Shiota, T. Morikawa, A. Kubo, T. Tani, T. Hishiki, T. Horiuchi, M. Suematsu and M. Kajimura
ACS nano   8(6) 5622-32   Jun 2014
Although SERS spectroscopy, which is sensitive to molecular vibration states, offers label-free visualization of molecules, identification of molecules and their reliable large-area imaging remains to be developed. Limitation comes from difficulti...

Conference Activities & Talks

Kubo Akiko,K. Fujii, K. Miyashita, T. Hishiki, H. Itoh, M. Suematsu
第89回日本生化学会年会   25 Sep 2016   日本生化学会
Cystathionine beta-synthase is required for maintaining levels of glutathione hydropersulfide, a novel antioxidant molecule in the murine lens
Kubo Akiko,Takafumi Yoshioka, Shinichi Goto, Isao Ishii, Takako Hishiki, Takehiro Yamamoto, Naoharu Takano, Takao Hoshino, Takashi Nakamura, Akitoshi Yoshida, Mayumi Kajimura, and Makoto Suematsu
第41回日本医用マススペクトル学会年会   15 Sep 2016   日本医用マススペクトル学会
Kubo Akiko,Kentaro Fujii, Kazutoshi Miyashita, Takako Hishiki, Hiroshi Itoh, Makoto Suematsu
21st International Mass Spectrometry Conference   20 Aug 2016   Canadian Society for Mass Spectrometry
Kubo Akiko
BMB2015   1 Dec 2015   日本分子生物学会・日本生化学会
Kubo Akiko
第63回質量分析総合討論会   18 Jun 2015   日本質量分析学会

Research Grants & Projects

Grant-in-Aid for Scientific Research
Project Year: Apr 2013 - Mar 2016    Investigator(s): 久保亜紀子


2017-040520 : 分析データ表示処理装置及び表示処理プログラム
特許第6153139号 : MALDI 用試料調製方法及び試料調製装置
特許第6115725号 : 質量分析を用いたアンモニア測定方法