Hayato Takahashi - My portal

Profile Information

Affiliation: Associate Professor, School of Medicine Department of Dermatology, Keio University

Degree: 博士（医学）(慶應義塾大学)

Researcher number: 40398615
J-GLOBAL ID: 201601002541284717
researchmap Member ID: 7000014249

Research Interests

Research Areas

Education

Apr, 2002 - Mar, 2006

内科系皮膚科学, 医学研究科, 慶應義塾大学大学院
Apr, 1994 - Mar, 2000

医学部, 慶應義塾大学

Committee Memberships

Awards

Jun, 2015

Young Dermatologist International Achievement Award 2015, International League of Dermatological Societies
Nov, 2012

三四会奨励賞受賞
Jun, 2012

平成24年度皆見省吾記念賞

Papers

Basement membrane zone IgE deposition is associated with bullous pemphigoid disease severity and treatment results

Basement membrane zone IgE deposition is, associated with, bullous pemphigoid, disease severity, atment results

British Journal of Dermatology, 182(5) 1221-1227, May, 2020 Peer-reviewed
Successful treatment with secukinumab of three psoriatic patients undergoing dialysis

Mukai M, Kurihara Y, Ito Y, Shintani Y, Takahashi H, Kubo A, Amagai M, Umegaki-Arao N

The Journal of dermatology, 47(1) e26-e28, Jan, 2020 Peer-reviewed
Autoimmunity and immunological tolerance in autoimmune bullous diseases

Takahashi H, Iriki H, Mukai M, Kamata A, Nomura H, Yamagami J, Amagai M

International immunology, 31(7) 431-437, Jul, 2019 Peer-reviewed
Patient voice on management of facial dermatological adverse events with targeted therapies: a qualitative study

Yagasaki K, Takahashi H, Ouchi T, Yamagami J, Hamamoto Y, Amagai M, Komatsu H

J Patient Rep Outcomes, 3(1) 27-27, May, 2019 Peer-reviewed
Gamma-delta T cell large granular lymphocyte leukaemia with multiple cutaneous nodules that showed spontaneous regression

Suzuki C, Hirai I, Nomura H, Ouchi T, Okayama M, Okamoto S, Amagai M, Tanese K, Takahashi H

J Eur Acad Dermatol Venereol, 33(3) e134-e137, Mar, 2019 Peer-reviewed
Development of an electronic medical record-based algorithm to identify patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan.

Toshiki Fukasawa, Hayato Takahashi, Norin Kameyama, Risa Fukuda, Shihori Furuhata, Nanae Tanemura, Masayuki Amagai, Hisashi Urushihara

PloS one, 14(8) e0221130, 2019
Regulatory T cell deficiency and autoimmune skin disease: beyond scurfy mouse and IPEX

Hashimoto, T. Takahashi, H. Sakaguchi, S

J Allergy Clin Immunol, Epub, Sep, 2018 Peer-reviewed
Vancomycin Mediates IgA Autoreactivity in Drug-Induced Linear IgA Bullous Dermatosis

Jun Yamagami, Yoshio Nakamura, Keisuke Nagao, Takeru Funakoshi, Hayato Takahashi, Akiko Tanikawa, Takahisa Hachiya, Toshiyuki Yamamoto, Akemi Ishida-Yamamoto, Toshihiro Tanaka …

Journal of Investigative Dermatology, 138(7) 1473-1480, Jul 1, 2018 Peer-reviewed
Unique clinical and serological features of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors

H. Horikawa, Y. Kurihara, T. Funakoshi, N. Umegaki-Arao, H. Takahashi, A. Kubo, A. Tanikawa, N. Kodani, Y. Minami, S. Meguro …

British Journal of Dermatology, 178(6) 1462-1463, Jun 1, 2018 Peer-reviewed
Case of lamotrigine-induced drug adverse reaction under tocilizumab treatment with clinical and virological features of drug-induced hypersensitivity syndrome.

Hisato Iriki, Takeshi Ouchi, Hiromi Ito, Miho Sawada, Miho Mukai, Hisashi Nomura, Yuko Baba, Takeya Adachi, Takeru Funakoshi, Masayuki Amagai …

The Journal of dermatology, 45(6) 738-741, Jun, 2018 Peer-reviewed
Azathioprine monotherapy in autoimmune blistering diseases: A feasible option for mild to moderate cases

Risa Kakuta, Jun Yamagami, Takeru Funakoshi, Hayato Takahashi, Manabu Ohyama, Masayuki Amagai

Journal of Dermatology, 45(3) 334-339, Mar 1, 2018 Peer-reviewed
Authors' reply: Paraneoplastic autoimmune multi-organ syndrome is a distinct entity from traditional pemphigus subtypes

Payne, A. S. Kasperkiewicz, M. Ellebrecht, C. T. Takahashi, H. Yamagami, J. Zillikens, D. Amagai, M

Nat Rev Dis Primers, 4 18013-18013, Feb, 2018
Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells

Daniela Y. Kitashima, Tetsuro Kobayashi, Therese Woodring, Kacey Idouchi, Thomas Doebel, Benjamin Voisin, Takeya Adachi, Takeshi Ouchi, Hayato Takahashi, Koji Nishifuji …

EBioMedicine, 27 293-303, Jan, 2018 Peer-reviewed
天疱瘡モデルマウスの特徴

高橋勇人

炎症と免疫, 26(1) 80-85, Jan, 2018
Desmoglein 3-Reactive B Cells "Hiding" in Pemphigus Lesions

Hayato Takahashi

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(11) 2255-2257, Nov, 2017
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report

Risa Fukuda, Takeshi Ouchi, Ikuko Hirai, Takeru Funakoshi, Aki Honda, Keiji Tanese, Akiko Tanikawa, Masayuki Amagai, Hayato Takahashi

CONTACT DERMATITIS, 77(2) 123-126, Aug, 2017 Peer-reviewed
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy

Hisashi Nomura, Hayato Takahashi, Satsuki Suzuki, Yuichi Kurihara, Shotaro Chubachi, Ichiro Kawada, Hiroyuki Yasuda, Tomoko Betsuyaku, Masayuki Amagai, Takeru Funakoshi

JOURNAL OF DERMATOLOGY, 44(7) 818-821, Jul, 2017 Peer-reviewed
皮膚科研究における若手育成の試み

高橋勇人

臨床皮膚科, 71(8) 574-575, Jul, 2017
Distinct phenotype of epidermolysis bullosa simplex with infantile migratory circinate erythema due to frameshift mutations in the V2 domain of KRT5

Y. Kumagai, N. Umegaki-Arao, T. Sasaki, Y. Nakamura, H. Takahashi, A. Ashida, Y. Tsunemi, M. Kawashima, A. Shimizu, A. Ishiko …

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 31(5) e241-e243, May, 2017 Peer-reviewed
Pemphigus

Kasperkiewicz, M, Ellebrecht, C.T, Takahashi, H, Yamagami, J, Zillikens, D, Payne, A.S, Amagai, M

Nature Reviews Disease Primers, 3 Article number 17026, May, 2017

Misc.

天疱瘡抗原デスモグレイン3に対する自己免疫応答と制御性T細胞の役割

高橋勇人, 天谷雅行

医学のあゆみ, 268(13) 1235-1240, Mar, 2019
Gamma-delta T cell large granular lymphocyte leukaemia with multiple cutaneous nodules that showed spontaneous regression

Suzuki C, Hirai I, Nomura H, Ouchi T, Okayama M, Okamoto S, Amagai M, Tanese K, Takahashi H

Journal of the European Academy of Dermatology and Venereology, 33(3) e134-e137, Mar, 2019
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

Hashimoto T, Takahashi H, Sakaguchi S

Journal of Allergy and Clinical Immunology, 142(6) 1754-1756, Dec, 2018
長期に観察した薬剤性過敏症症候群（DIHS）

福田理紗, 高橋勇人

Visual Dermatology, 17(9) 869-871, Aug, 2018
Unique clinical and serological features of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors

H. Horikawa, Y. Kurihara, T. Funakoshi, N. Umegaki-Arao, H. Takahashi, A. Kubo, A. Tanikawa, N. Kodani, Y. Minami, S. Meguro …

British Journal of Dermatology, 178(6) 1462-1463, Jun 1, 2018
薬剤アレルギーの注意点からだと心健康相談

高橋勇人

すこやかファミリー, 5月号 30, May, 2018
Paraneoplastic autoimmune multi-organ syndrome and paraneoplastic pemphigus describe the same spectrum of disease pathology

Aimee S. Payne, Michael Kasperkiewicz, Christoph T. Ellebrecht, Hayato Takahashi, Jun Yamagami, Detlef Zillikens, Masayuki Amagai

Nature Reviews Disease Primers, 4, Feb 22, 2018
天疱瘡モデルマウスから広がる自己免疫病態の理解

皮膚科臨床アセット19「水疱性皮膚疾患」, 19 59-64, Mar, 2014
天疱瘡と表皮特異的T細胞による皮膚炎

高橋勇人, 天谷雅行

最新医学, 6月増刊号 1409-1419, Jun, 2013

Books and Other Publications

眼疾患アトラスシリーズ第3巻『外眼部アトラス』

高橋勇人

総合医学社, Oct, 2019
皮膚科のくすりの使い方

高橋勇人

じほう, Aug, 2019
私の治療2019-20年度

高橋勇人

日本医事新報社, Jul, 2019
ガイドライン外来診療 2019

高橋勇人

日経メディカル開発, Mar, 2019
皮膚症状110症例でみる内科疾患

高橋勇人

日本医事新報社, Sep, 2018
1336専門家による私の治療. 2017-18年度版

高橋勇人

日本医事新報社, Jul, 2017
薬疹の診断と治療アップデート重症薬疹を中心に

高橋勇人

医薬ジャーナル社, May, 2016
Immunology of the Skin

Yamagami, J. Takahashi, H. Amagai, M

Springer, Apr, 2016

Presentations

108

Blockade of pathogenic immunoglobulin class-switch is a tolerogenic process to prevent pemphigus development in desmoglein 3-sepecific B cell receptor knock-in mouse

Nomura H, Takahashi H, Yamagami J, Fujii H, Koseki H, Watanabe T, Ohara O, Koyasu S, Amagai M

48th Annual Meeting of The Japanese Society for Immunology, Dec 11, 2019
IL-27 is crucial in anti-desmoglein 3 autoantibody production in pemphigus vulgaris mouse model

Kamata A, Takahashi H, Yoshida H, Yamagami J, Amagai M

48th Annual Meeting of the Japanese Society for Immunology, Dec 11, 2019
The clinical utility of basophil activation test in diagnosis of hypersensitivity due to fermented soybeans,natto

Fukuda R, Ouchi T, Shiiya C, Yasuda-Sekiguchi F, Kouno M, Takahashi S, Amagai M, Takahashi H

EAACI Allegy School on Food Allergy, Dec 5, 2019
薬疹経過中に自己抗体が出現した薬剤性過敏症症候群および疑い例の検討

椎谷千尋, 大内健嗣, 舩越建, 天谷雅行, 高橋勇人

第49回日本皮膚免疫アレルギー学会総会学術大会, Nov 29, 2019
Evaluation on cytokine and transcriptional factor impacts on cholesterol 25-hydroxylase induction in CD4+ T cells

Takahashi H, Isami K, Amagai M

44th Annual Meeting of the Japanese Society for Investigative Dermatology, Nov 8, 2019
Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of autoreactive B cells in pemphigus patients

Egami S, Watanabe T, Nomura H, Takahashi H, Yamagami J, Ohara O, Amagai M

44th Annual meeting of the Japanese Society for Investigative Dermatology, Nov 8, 2019
Animal model for autoimmunity to desmoglein 3, “for beating autoimmunity by understanding tolerance”

Takahashi H

Shanghai International Bullous Disease Meeting, Oct 18, 2019
全身性エリテマトーデス患者に生じた汎発性脂肪織炎の1例

江上将平, 新川宏樹, 田中諒, 筋野和代, 宮本樹里亜, 高橋勇人, 天谷雅行, 安岡秀剛, 谷川瑛子

第71回日本皮膚科学会西部支部学術大会, Sep 7, 2019
Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Anticonvulsants in Japan

Fukasawa T, Takahashi H, Tanemura N, Amagai M, Urushihara H

35th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Aug 24, 2019
Cholesterol 25-hydroxylase expressing CD4+ T cell regulates skin inflammation

Takahashi H, Nomura H, Iriki H, Kubo A, Mukai M, Sasaki T, Mikami Y, Kanno Y, O’Shea J, Amagai M

60th International Conference on the Bioscience of Lipids, Jun 17, 2019
Successful treatment with secukinumab of 3 dialysis patients with psoriasis vulgaris and psoriatic arthritis

Mukai M, Kurihara Y, Ito Y, Takahashi H, Amagai M, Umegaki-Arao N

24th World Congress of Dermatology (WCD), Jun 10, 2019
注意すべき薬剤性過敏症症候群の特徴

高橋勇人

第118回日本皮膚科学会総会, Jun 6, 2019
IgE in vivo deposition is related to severity and treatment results of bullous pemphigoid

Kamata A, Kurihara Y, Funakoshi T, Takahashi H, Kuroda K, Hachiya T, Amagai M, Yamagami J

118th Annual Meeting of the Japanese Dermatological Association, Jun 6, 2019
Regulatory T cell-mediated, OX40-dependent peripheral tolerance to autoantigen, desmoglein 3

Iriki H, Takahashi H, Wada N, Amagai M

77th Annual Meeting of the Society for Investigative Dermatology (SID 2019), May 8, 2019
抗てんかん薬によるスティーヴンス・ジョンソン症候群および中毒性表皮壊死症発症のリスク評価

深澤俊貴, 高橋勇人, 種村菜奈枝, 漆原尚巳

第139回日本薬学会総会, Mar 20, 2019
Cholesterol 25-hydroxylase expressing CD4+ T cell regulates tissue inflammation

Takahashi, H. Nomura, H. Iriki, H. Kubo, A. Mukai, M. Sasaki, T. Mikami, Y Kanno, Y. O’Shea, J. Amagai, M

47th Annual Meeting of the Japanese Society for Immunology, Dec 10, 2018
全身性エリテマトーデス患者に生じた汎発性脂肪織炎の1例

江上将平, 新川宏樹, 田中諒, 筋野和代, 宮本樹里亜, 高橋勇人, 天谷雅行, 安岡秀剛, 谷川瑛子

第70回日本皮膚科学会西部支部学術大会, Nov 10, 2018
中毒性表皮壊死症を合併し、瘢痕治癒部に乾癬の皮疹を生じた乾癬患者の1例

向井美穂, 栗原佑一, 野村尚志, 新谷悠花, 天谷雅行, 高橋勇人, 梅垣知子

第70回日本皮膚科学会西部支部学術大会, Nov 10, 2018
Induction of psoriasis on the scars following toxic epidermal necrolysis

Mukai M, Kurihara Y, Nomura H, Shintani Y, Amagai M, Takahashi H, Umegaki-Arao

10th International Congress on Cutaneous Adverse Drug Reactions, Nov 10, 2018
電子カルテデータからスティーブンス・ジョンソン症候群および中毒性表皮壊死症を特定するアルゴリズムの検討

深澤俊貴, 高橋勇人, 亀山南琳, 福田理紗, 古畑汐梨, 種村菜奈枝, 天谷雅行, 漆原尚巳

第24回日本薬剤疫学会学術総会, Oct 13, 2018

Teaching Experience

Professional Memberships

Works

International League of Dermatological Societies-Newsletter「ILDS 2015 Young Dermatologist International Achievement Award(YDIAA) Winners」

Hayato Takahashi

Dec, 2015 Other
慶應義塾医学部新聞「デスモグレイン3反応性T細胞による新規自己免疫性皮膚炎モデルの確立」

高橋勇人

Nov 20, 2012 Other
慶應義塾医学部新聞「日本皮膚科学会皆見省吾記念賞受賞」

高橋勇人

Jul 12, 2012 Other

Research Projects

[免疫アレルギー疾患等実用化研究事業免疫アレルギー疾患実用化研究分野] 重症薬疹サンプルの選定、採取およびウィルス叢と疾患発症との関連性解析

AMED（国立研究開発法人日本医療研究開発機構）, 2015 - Present

阿部理一郎
［基盤研究A］病態に直結するT細胞レパトアの制御を目指した、新たな免疫制御機構の同定と解析

基盤研究A, Apr, 2019 - Mar, 2023

高橋勇人
［慶應義塾・学事振興資金（個人研究特B）］天疱瘡自己抗原に対する末梢性免疫寛容機構の解明

慶應義塾学事振興資金, Apr, 2018 - Mar, 2019
［革新的先端研究開発支援事業］ PRIME 新規T細胞サブセットを規定するコレルテロール代謝酵素の機能解析と疾患制御への応用

AMED（国立研究開発法人日本医療研究開発機構）-PRIME, 2016 - 2019

高橋勇人
Molecular mechanism of skin inflammation induced by desmoglein 3-specific T cells

Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), MEXT,JSPS, Apr, 2014 - Mar, 2017

高橋勇人
[難治性疾患等克服研究事業（難治性疾患等実用化研究事業）] 重症薬疹における特異的細胞死誘導受容体をターゲットにした新規治療薬開発

国立研究開発法人日本医療研究開発機構（AMED）, 2014 - 2016

阿部理一郎
［難治性疾患等政策研究事業（難治性疾患政策研究事業）］重症多形滲出性紅斑に関する調査研究

Health and Labour Sciences Research Grants, 2014 - 2016

森田栄伸
［基盤研究 B］ 26293258 デスモグレイン3特異的細胞性免疫が誘導する皮膚炎モデルの分子病態の解明

Grant-in-Aid for Scientific Research, 2014 - 2016
［坂口光洋記念慶應義塾医学振興基金］天疱瘡自己抗原デスモグレイン3に対するT細胞末梢免疫寛容機構の解析

坂口光洋記念慶應義塾医学振興基金, Apr, 2014 - Mar, 2015
［慶應義塾・学事振興資金（個人研究特B）］新規ヘルパーT細胞サブセットの同定と実験的自己免疫性皮膚炎における役割の解析

Keio Gijuku Academic Development Funds, 2013 - 2015
［慶應義塾・学事振興資金（個人研究A)］新規ヘルパーT細胞サブセットの同定と実験的自己免疫性皮膚炎における役割の解析

Keio Gijuku Academic Development Funds, Apr, 2013 - Mar, 2014

高橋勇人

Industrial Property Rights

特願2019-214253 自己免疫疾患における自己抗体産生を抑制するシグナル阻害自己免疫疾患治療剤

高橋勇人, 天谷雅行, 吉田裕樹
特許出願2016-111556 ２５−ヒドロキシコレステロールを有効成分として含有してなる、活性化されたT細胞及び／又はB細胞に選択的な細胞死誘導剤又は細胞死促進剤

Hayato Takahashi, Masayuki Amagai