obata koji

J-GLOBAL         Last updated: Nov 14, 2019 at 09:51
obata koji
Gifu University
Graduate School of Medicine

Research Areas


Published Papers

Obata K, Morita H, Takaki M.
Naunyn Schmiedebergs Arch Pharmacol.   392(9) 1065-1070   Sep 2019   [Refereed]
A novel myosin activator, omecamtiv mecarbil (OM), is a cardiac inotropic agent with a unique new mechanism of action, which is thought to arise from an increase in the transition rate of myosin into the actin-bound force-generating state without ...
Obata K,Takeshita D, Morita H, Takaki M.
Sci Rep   8(1) 16246   Nov 2018   [Refereed]
We investigated the effects of altering cardiac temperature on left ventricular (LV) myocardial mechanical work and energetics using the excised, cross-circulated rat heart model. We analyzed the LV end-systolic pressure-volume relationship (ESPVR...
Kawao N, Morita H, Obata K, Tatsumi K, Kaji H
Journal of cellular physiology   233(2) 1191-1201   Feb 2018   [Refereed]
Interactions between muscle and bone have been recently noted. We reported that the vestibular system plays crucial roles in the changes in muscle and bone induced by hypergravity in mice. However, the details of the mechanisms by which gravity ch...
Obata K, Takaki M
Methods in molecular biology (Clifton, N.J.)   1816 117-132   2018   [Refereed]
The Emax-Pressure-Volume Area (PVA)-VO2 framework proposed by Dr. Suga for canine hearts has dramatically advanced the field of cardiac mechanical work and energetics, i.e., mechanoenergetics. He and his collaborators investigated mechanoenergetic...
Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H
The journal of physiological sciences : JPS      Sep 2017   [Refereed]
We recently reported that hypergravity with 3 g for 4 weeks affects muscle and bone through the vestibular system in mice. The purpose of this study was to investigate the effects of hypergravity with 2 g, which had no influence on circulating glu...
Kawao N, Morita H, Obata K, Tamura Y, Okumoto K, Kaji H
Physiological reports   4(19)    Oct 2016   [Refereed]
Gravity changes concurrently affect muscle and bone as well as induce alterations in vestibular signals. However, the role of vestibular signals in the changes in muscle and bone induced by gravity changes remains unknown. We therefore investigate...
Morita H, Obata K, Abe C, Shiba D, Shirakawa M, Kudo T, Takahashi S
PloS one   10(7) e0133981   2015   [Refereed]
To elucidate the pure impact of microgravity on small mammals despite uncontrolled factors that exist in the International Space Station, it is necessary to construct a 1 g environment in space. The Japan Aerospace Exploration Agency has developed...
Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
PloS one   10(10) e0141650   2015   [Refereed]
Gravity change affects many immunological systems. We investigated the effects of hypergravity (2G) on murine thymic cells. Exposure of mice to 2G for three days reduced the frequency of CD4+CD8+ thymocytes (DP) and mature medullary thymic epithel...
Yamada A, Torimoto K, Obata K, Hirayama A, Fujimoto K, Takaki M
The journal of physiological sciences : JPS   64(1) 21-30   Jan 2014   [Refereed]
A functional impairment of the bladder and heart in a decompensated state caused by a pressure overload is accompanied by a decrease in the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2). The beneficial effects of SERCA2 overexpression in preservin...
Aoki K, Obata K, Kurihara M, Kuniyasu H, Kirita T, Takaki M
International journal of clinical oncology   19(3) 549-556   2014   [Refereed]
Taste disorders are frequently observed in cancer patients undergoing chemotherapy and are serious adverse events which impair the QoL of the cancer patient. Nevertheless, taste disorder mechanisms in cancer patients undergoing chemotherapy have n...
Mitsuyama Shinichi, Takeshita Daisuke, Obata Koji, Zhang Guo-Xing, Takaki Miyako
Journal of molecular and cellular cardiology   59 95-106   Mar 2013   [Refereed]
Overexpression of cardiac sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) has been suggested as a strategic intervention for cardiac failure. However, its benefit in wild-type (WT) rats with normal SERCA2a levels seems to be small. To investigate w...
Goto Kei, Kato Go, Kawahara Isao, Luo Yi, Obata Koji, Misawa Hiromi, Ishikawa Tatsuya, Kuniyasu Hiroki, Nabekura Junich, Takaki Miyako
PloS one   8(1) e54814   2013   [Refereed]
One of the challenges of using imaging techniques as a tool to study cellular physiology has been the inability to resolve structures that are not located near the surface ofthe preparation. Nonlinear optical microscopy, in particular two photon-e...
Zhang Guo-Xing, Obata Koji, Takeshita Daisuke, Mitsuyama Shinichi, Nakashima Tamiji, Kikuta Akio, Hirabayashi Masumi, Tomita Koichi, Vetter Roland, Dillmann Wolfgang H, Takaki Miyako
The journal of physiological sciences : JPS   62(3) 221-31   May 2012   [Refereed]
Cardiac sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) is responsible for most of the Ca(2+) removal during diastole and a larger Ca(2+) handling energy consumer in excitation-contraction (E-C) coupling. To understand the cardiac performanceu...
Hattori Hiroshi, Takeshita Daisuke, Takeuchi Ayako, Kim Bongju, Shibata Munetaka, Matsuoka Satoshi, Obata Koji, Mitsuyama Shinichi, Zhang Guo-Xing, Takaki Miyako
Biochemical and biophysical research communications   419(2) 431-5   Mar 2012   [Refereed]
We previously reported that left ventricular (LV) slices from isoproterenol (ISO)-induced hypertrophied rat hearts showed an increase of energy expenditure due to remodeling of Ca(2+) handling in excitation-contraction coupling, i.e., suppressed S...
Kawahara Isao, Kuniyasu Hiroki, Matsuyoshi Hiroko, Goto Kei, Obata Koji, Misawa Hiromi, Fujii Hisao, Takaki Miyako
American journal of physiology. Gastrointestinal and liver physiology   302(6) G588-97   Mar 2012   [Refereed]
It was recently reported that activation of enteric neural 5-HT(4) receptors (SR4) promotes reconstruction of enteric neural circuit injury in distal gut of guinea pigs and that this reconstruction involves neuralstem cells. We aimed to explore a ...
Asada Keiji, Obata Koji, Horiguchi Kazuhide, Takaki Miyako
American journal of physiology. Cell physiology   302(5) C757-65   Mar 2012   [Refereed]
Bone homeostasis is regulated by mechanical stimulation (MS). The sensory mechanism of bone tissue for MS remains unknown in the maintenance of bone homeostasis. We aimed to investigate the sensory mechanism from osteoblasts to sensory neurons in ...
Shibata Munetaka, Takeshita Daisuke, Obata Koji, Mitsuyama Shinichi, Ito Haruo, Zhang Guo-Xing, Takaki Miyako
American journal of physiology. Heart and circulatory physiology   301(5) H2154-60   Nov 2011   [Refereed]
Impaired Ca(2+) handling is one of the main characteristics in heart failure patients. Recently, we reported abnormal expressions of Ca(2+)-handling proteins in isoproterenol (ISO)-induced hypertrophied rat hearts. On the other hand, Na(+)/H(+) ex...
Takaki Miyako, Misawa Hiromi, Matsuyoshi Hiroko, Kawahara Isao, Goto Kei, Zhang Guo-Xing, Obata Koji, Kuniyasu Hiroki
Biochemical and biophysical research communications   406(4) 529-33   Mar 2011   [Refereed]
Using an embryoid body (EB) culture system, we developed a functional organ-like cluster, a"gut", from mouse embryonic stem (ES) cells (ES gut). Each ES gut exhibited various types of spontaneous movements. In these spontaneously contracting ES gu...
Matsuyoshi Hiroko, Nakagawa Tadashi, Zhang Guo-Xing, Obata Koji, Misawa Hiromi, Kawahara Isao, Takaki Miyako
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   46(3) 143-56   2010   [Refereed]
In the ileum of W/W(v) mutant mice (W/W(v)), the absence of interstitial cells of Cajal (ICC) in the myenteric region (ICC-MY), and cross-talk between ICC in the deep muscular region (ICC-DMP) and enteric nitrergic motor nerves leads to irregular ...
Zhang Guo-Xing, Kimura Shoji, Murao Koji, Yu Xiao, Obata Koji, Matsuyoshi Hiroko, Takaki Miyako
Journal of pharmacological sciences   113(3) 224-33   2010   [Refereed]
A close interaction between adrenergic nerves and angiotensin systems has been documented. The present study was designed to investigate the mechanisms of angiotensin-receptor blocker (ARB) suppression of beta-adrenergic receptor stimulation-induc...
Nishizawa Takao, Cheng Xian Wu, Jin Zhehu, Obata Koji, Nagata Kohzo, Hirashiki Akihiro, Sasaki Takeshi, Noda Akiko, Takeshita Kyosuke, Izawa Hideo, Shi Guo-Ping, Kuzuya Masafumi, Okumura Kenji, Murohara Toyoaki
Journal of hypertension   28(7) 1515-26   Jul 2010   [Refereed]
The beneficial cardiac effects of some Ca(2+) channel blockers have been attributed to blood pressure reduction, but these pleiotropic effects require further investigation. We compared the effects of benidipine, which has beneficial cardiac effec...
Yoshikawa Yoshiro, Zhang Guo-Xing, Obata Koji, Matsuyoshi Hiroko, Asada Keiji, Taniguchi Shigeki, Takaki Miyako
American journal of physiology. Heart and circulatory physiology   299(2) H396-401   Aug 2010   [Refereed]
We have previously shown that a newly developed calpain inhibitor, SNJ-1945 (SNJ), with good aqueous solubility prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteol...
Yoshikawa Yoshiro, Zhang Guo-Xing, Obata Koji, Ohga Yoshimi, Matsuyoshi Hiroko, Taniguchi Shigeki, Takaki Miyako
American journal of physiology. Heart and circulatory physiology   298(2) H643-51   Feb 2010   [Refereed]
We have previously indicated that calpain inhibitor-1 prevents the heart from ischemia- reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin. However, thisinhibitor is insoluble w...
Zhang Guo-Xing, Kimura Shoji, Murao Koji, Obata Koji, Matsuyoshi Hiroko, Takaki Miyako
American journal of physiology. Heart and circulatory physiology   298(2) H433-9   Feb 2010   [Refereed]
The release of cytochrome c from the mitochondria to the cytosol is a critical step for downstream caspase-mediated apoptotic signal transduction in ischemia-reperfusion (I/R)-induced myocardial tissue injury. 10-N-nonyl acridine orange (NAO), a c...
Nakajima-Takenaka Chikako, Zhang Guo-Xing, Obata Koji, Tohne Kiyoe, Matsuyoshi Hiroko, Nagai Yukiko, Nishiyama Akira, Takaki Miyako
American journal of physiology. Heart and circulatory physiology   297(5) H1736-43   Nov 2009   [Refereed]
We investigated left ventricular (LV) mechanical work and energetics in the cross-circulated (blood-perfused) isoproterenol [Iso 1.2 mg x kg(-1).day(-1) for 3 days (Iso3) or 7 days (Iso7)]-induced hypertrophied rat heart preparation under isovolum...
Cheng Xian Wu, Okumura Kenji, Kuzuya Masafumi, Jin Zhehu, Nagata Kohzo, Obata Koji, Inoue Aiko, Hirashiki Akihiro, Takeshita Kyosuke, Unno Kazumasa, Harada Ken, Shi Guo-Ping, Yokota Mitsuhiro, Murohara Toyoaki
Journal of cardiovascular pharmacology   54(1) 47-56   Jul 2009   [Refereed]
To investigate the mechanism responsible for the increased cardiac stiffness associated with hypertensive heart failure in Dahl salt-sensitive (DS) rats and the effects of treatment with the combination of a calcium channel blocker [azelnidipine (...
Yamada Takashi, Nagata Kohzo, Cheng Xian Wu, ObataKoji, Saka Masako, Miyachi Masaaki, Naruse Keiko, Nishizawa Takao, Noda Akiko, Izawa Hideo, Kuzuya Masafumi, Okumura Kenji, Murohara Toyoaki, Yokota Mitsuhiro
European journal ofpharmacology   615(1-3) 163-70   Aug 2009   [Refereed]
The Ca2+ channel blocker nifedipine has been reported to reduce the rate of new overt heart failure. We investigated the effects of nifedipine on left ventricular remodeling, oxidative stress, and gene expression in the failing heart of Dahl salt-...
Kobayashi Masakazu, Izawa Hideo, Cheng Xian Wu, Asano Hiroyuki, Hirashiki Akihiro, Unno Kazumasa, Ohshima Satoru, Yamada Takashi, Murase Yosuke, Kato Tomoko S, Obata Koji, Noda Akiko, Nishizawa Takao, Isobe Satoshi, Nagata Kohzo, Matsubara Tatsuaki, Murohara Toyoaki, Yokota Mitsuhiro
JACC. Cardiovascular imaging   1(6) 718-26   Nov 2008   [Refereed]
We performed dobutamine stress testing for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy (DCM).
Kato Mayuko F, Shibata Rei, Obata Koji, Miyachi Masaaki, Yazawa Hiroki, Tsuboi Koji, Yamada Takashi, Nishizawa Takao, Noda Akiko, Cheng Xian Wu, Murate Takashi, Koike Yasuo, Murohara Toyoaki, Yokota Mitsuhiro, Nagata Kohzo
Journal of hypertension   26(8) 1669-76   Aug 2008   [Refereed]
Cardiac hypertrophy is common in diabetes and an independent risk factor for cardiac morbidity and mortality. We investigated the effects of pioglitazone on cardiac hypertrophy and hypertrophic signaling in Dahl salt-sensitive hypertensive rats.
Cheng Xian Wu, Murohara Toyoaki, Kuzuya Masafumi, Izawa Hideo, Sasaki Takeshi, Obata Koji, Nagata Kohzo, Nishizawa Takao, Kobayashi Masakazu, Yamada Takashi, Kim Weon, Sato Kohji, Shi Guo-Ping, Okumura Kenji, Yokota Mitsuhiro
The American journal of pathology   173(2) 358-69   Aug 2008   [Refereed]
The elastolytic activity of cathepsins in the myocardium is implicated in hypertensive heart failure (HF). Given that reactive oxygen species are also implicated in protease activation associated with cardiac remodeling, we examined the role of th...
Hayashi Keiko, Kimata Hirotaka, Obata Koji, Matsushita Aya, Fukata Ayako, Hashimoto Katsunori, Noda Akiko, Iwase Mitsunori, Koike Yasuo, Yokota Mitsuhiro, Nagata Kohzo
Journal of cardiac failure   14(3) 238-44   Apr 2008   [Refereed]
Oxidative stress is implicated in cardiac remodeling and failure. We tested whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and attenuate left ventricular (LV) remodeling and dysfunction in the TO-2 hamster mode...
Obata Koji, Furuno Tadahide, Nakanishi Mamoru, Togari Akifumi
FEBS letters   581(30) 5917-22   Dec 2007   [Refereed]
Using an in vitro co-culture approach comprising cultured murine superior cervical ganglia and MC3T3-E1 osteoblast-like cells, we found that the addition of scorpion venom (SV) elicited neurite activation via intracellular Ca2+ mobilization and, a...
Saka Masako, Obata Koji, Ichihara Sahoko, Cheng Xian Wu, Kimata Hirotaka, Noda Akiko, Izawa Hideo, Nagata Kohzo, Yokota Mitsuhiro
Clinical and experimental pharmacology&physiology   33(12) 1164-71   Dec 2006   [Refereed]
1. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) manifest pleiotropic effects that may contribute to their therapeutic efficacy. However, the mechanism of the beneficial action of statins on cardiac hypertrophy and fibros...
Cheng Xian Wu, Obata Koji, Kuzuya Masafumi, Izawa Hideo, Nakamura Kae, Asai Eri, Nagasaka Tetsuro, Saka Masako, Kimata Takahiro, Noda Akiko, Nagata Kohzo, Jin Hai, Shi Guo-Ping, Iguchi Akihisa, Murohara Toyoaki, YokotaMitsuhiro
Hypertension   48(5) 979-87   Nov 2006   [Refereed]
Cathepsins are cysteine proteases that participate in various types of tissue remodeling. However, their expressions during myocardial remodeling have not been examined. In this study, we investigated their expressions in the left ventricular (LV)...
Saka Masako, Obata Koji, Ichihara Sahoko, Cheng Xian Wu, Kimata Hirotaka, Nishizawa Takao, Noda Akiko, Izawa Hideo, Nagata Kohzo, Murohara Toyoaki, Yokota Mitsuhiro
Journal of cardiovascular pharmacology   47(6) 770-9   Jun 2006   [Refereed]
Statin therapy may be associated with lower mortality in patients with heart failure, but the underlying mechanism of such an association is unknown. We haveevaluated the effects of pitavastatin on cardiac function and survival in a rat model of h...
Ichihara Sahoko, Obata Koji, Yamada Yoshiji, Nagata Kohzo, Noda Akiko, Ichihara Gaku, Yamada Akira, Kato Tomoko, Izawa Hideo, Murohara Toyoaki, Yokota Mitsuhiro
Journal of molecular and cellular cardiology   41(2) 318-29   Aug 2006   [Refereed]
Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is a key regulator of lipid and glucose metabolism and is implicated in inflammation. We investigated the effects of the PPAR-alpha activator fenofibrate on, as well as the role of redo...
Hirashiki Akihiro, Izawa Hideo, Somura Fuji, Obata Koji, Kato Tomoko, Nishizawa Takao, Yamada Akira, Asano Hiroyuki, Ohshima Satoru, Noda Akiko, Iino Shigeo, Nagata Kohzo, Okumura Kenji, Murohara Toyoaki, Yokota Mitsuhiro
Journal of the American College of Cardiology   47(7) 1382-9   Apr 2006   [Refereed]
The relation between the occurrence of pacing-induced mechanical alternans and prognosis in patients with mild-to-moderate idiopathic dilated cardiomyopathy (IDCM) in sinus rhythm was investigated prospectively. The myocardial expression of genes ...
Nagata Kohzo, Obata Koji, Xu Jinglan, Ichihara Sahoko, Noda Akiko, Kimata Hirotaka, Kato Tomoko, Izawa Hideo, Murohara Toyoaki, Yokota Mitsuhiro
Hypertension   47(4) 656-64   Apr 2006   [Refereed]
Chronic elevation of plasma aldosterone contributes to heart failure. Mineralocorticoid receptor (MR) antagonism is cardioprotective in such a setting, but whether such protection occurs in the presence of low-aldosterone concentrations remains un...
Ohshima Satoru, Isobe Satoshi, Izawa Hideo, Nanasato Mamoru, Ando Akitada, Yamada Akira, Yamada Kiyoyasu, Kato Tomoko S, Obata Koji, Noda Akiko, Nishizawa Takao, Kato Katsuhiko, Nagata Kohzo, Okumura Kenji, Murohara Toyoaki, Yokota Mitsuhiro
Journal of the American College of Cardiology   46(11) 2061-8   Dec 2005   [Refereed]
We investigated the relationship between iodine-123-metaiodobenzylguanidine (123I-MIBG) findings and myocardial contractile reserve in patients with mild to moderate dilated cardiomyopathy (DCM).
Izawa Hideo, Murohara Toyoaki, Nagata Kohzo, Isobe Satoshi, Asano Hiroyuki, Amano Tetsuya, Ichihara Sahoko, Kato Tomoko, Ohshima Satoru, Murase Yosuke, Iino Shigeo, Obata Koji, Noda Akiko, Okumura Kenji,YokotaMitsuhiro
Circulation   112(19) 2940-5   Nov 2005   [Refereed]
Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor antagonist spironolactone on left ventricular (LV) function and chamber stiffnes...
Obata Koji, Nagata Kohzo, Iwase Mitsunori, Odashima Mari, Nagasaka Tetsuro, Izawa Hideo, Murohara Toyoaki, Yamada Yoshiji, Yokota Mitsuhiro
Biochemical and biophysical research communications   338(2) 1299-305   Dec 2005   [Refereed]
The possible role of calcineurin in cardiac hypertrophy induced by calmodulin (CaM) overexpression in the heart was investigated. CaM transgenic (CaM-TG) mice developed marked cardiac hypertrophy and exhibited up-regulation of atrial natriuretic f...
Xu Jinglan, Nagata Kohzo, Obata Koji, Ichihara Sahoko, Izawa Hideo, Noda Akiko, Nagasaka Tetsuro, Iwase Mitsunori, Naoe Tomoki, Murohara Toyoaki, Yokota Mitsuhiro
Hypertension   46(4) 719-24   Oct 2005   [Refereed]
Long-term administration of vasodilators increases shear stress, which is thought to be important for vascular growth in the heart. Nicorandil, an activator of ATP-sensitive potassium channels with a nitrate-like action, is a potent vasodilator. W...
Ichihara Sahoko, Noda Akiko, Nagata Kohzo, Obata Koji, Xu Jinglan, Ichihara Gaku, Oikawa Shinji, Kawanishi Shosuke, Yamada Yoshiji, Yokota Mitsuhiro
Cardiovascular research   69(3) 726-35   Feb 2006   [Refereed]
Oxidative stress is implicated in the pathogenesis of heart failure and affects the activity of matrix metalloproteinases (MMPs). We have now investigated the role of MMPs and their tissue inhibitors (TIMPs) in the transition from compensated left...
Kato Tomoko S, Noda Akiko, Izawa Hideo, Yamada Akira, Obata Koji, Nagata Kohzo, Iwase Mitsunori, Murohara Toyoaki, Yokota Mitsuhiro
Circulation   110(25) 3808-14   Dec 2004   [Refereed]
The differentiation of hypertrophic cardiomyopathy (HCM)from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether...
Nishizawa Takao, Iwase Mitsunori, Kanazawa Hiroaki, Ichihara Sahoko, Ichihara Gaku, Nagata Kohzo, Obata Koji, Kitaichi Kiyoyuki, Yokoi Toyoharu, Watanabe Masato, Tsunematsu Takashi, Ishikawa Yoshihiro, Murohara Toyoaki, Yokota Mitsuhiro
Circulation journal : official journal of the Japanese Circulation Society   68(11) 1051-60   Nov 2004   [Refereed]
The relationship betweenenhanced myocardial oxidative stress and impaired beta-adrenergic signaling remains to be characterized during the development of dilated cardiomyopathy.
Nagata Kohzo, Obata Koji, Odashima Mari, Yamada Akira, Somura Fuji, Nishizawa Takao, Ichihara Sahoko, Izawa Hideo, Iwase Mitsunori, Hayakawa Akemi, Murohara Toyoaki, Yokota Mitsuhiro
Journal of molecular and cellular cardiology   35(12) 1505-12   Dec 2003   [Refereed]
The anti-anginal drug nicorandil has been shown to inhibit apoptosis by activating mitochondrial ATP-sensitive potassium (K(ATP)) channels. The possiblecontribution of the nitrate moiety of this drug to its anti-apoptotic effect has now been inves...
Yazawa Shigenobu, ObataKoji, Iio Akio, Koide Masafumi, Yokota Mitsuhiro, Sasaki Shin-ichi, Kagami Hiroshi, Ono Tamao
Comparative biochemistry andphysiology. Part A, Molecular&integrative physiology   136(2) 391-9   Oct 2003   [Refereed]
FKBPs are cytosolic receptors for the immunosuppressive drug FK506. FKBP12.6 and FKBP12 associate with cardiac and skeletal muscle isoforms of ryanodine receptors and thereby regulate intracellular Ca(2+)release. The amino acid sequences of FKBP12...
Yazawa Shigenobu, Obata Koji, Iio Akio, Koide Masafumi, Yokota Mitsuhiro, Sasaki Shin-Ichi, Kagami Hiroshi, Ono Tamao
Developmental dynamics : an official publication of the American Association of Anatomists   226(1) 33-41   Jan 2003   [Refereed]
FKBP12.6, a member of the family of FK506-binding proteins, selectively associates with the cardiac isoform of the ryanodine receptor and thereby stabilizes this Ca(2+) release channel. A chicken FKBP12.6 (chFKBP12.6) cDNA was cloned and shown to ...
Obata K, Koide M, Nagata K, Iio A, Yazawa S, Ono T, Sasaki S, Yamada Y, Tuan RS, Yokota M
Animal Science Journal   73 229-234   Aug 2002   [Refereed]
Nagata Kohzo, Somura Fuji, Obata Koji, OdashimaMari, Izawa Hideo, Ichihara Sahoko, Nagasaka Tetsuro, Iwase Mitsunori, Yamada Yoshiji, Nakashima Nobuo, Yokota Mitsuhiro
Hypertension   40(2) 168-74   Aug 2002   [Refereed]
The possible role of calcineurin in the attenuation of cardiac hypertrophy and fibrosis by blockade of the angiotensin II type 1 (AT1) receptor was investigated in Dahl salt-sensitive (DS) rats. The effect of the calcineurin inhibitor FK506 was al...
Obata K, Koide M, Nagata K, Iio A, Yazawa S, Ono T, Yamada Y, Tuan R S, Yokota M
Biochemical and biophysical research communications   283(3) 613-20   May 2001   [Refereed]
A cDNA encoding chicken FK506-binding protein 12 (FKBP12) was isolated and sequenced. The predicted amino acid sequence of the chicken protein shows high homology to those of FKBP12 proteins of other species ranging from human to frog. The possibl...
Harayama H, Koide M, Obata K, Iio A, Iida M, Matsuda N, Akins R E, Yokota M, Tuan R S, Saito H
Journal of cellular physiology   177(2) 289-98   Nov 1998   [Refereed]
An accelerated weight gain is noted in the heart of Ca-deficient, hypertensive chick embryos maintained in a shell-less culture in vitro.We previously observed that the Ca handling property of cardiomyocytes isolated from the shell-less embryo is ...
Function of FK506 binding protein (FKBP) in chick embryonic cardiac development.
Koide M, Obata K, Iio A, Iida M, Harayama H, Yokota M, Tuan R S
Heart and vessels   Suppl 12 7-9   1997   [Refereed]
FK506 binding protein (BP) 12, an immunophilin of FK506-binding proteins, is involved in intra-cellular signal transduction through the calcineurin-nuclear factor pathway. FKBP12 is reported to be associated with the ryanodine-receptor and IP3 Ca2...
Major risk factors for atherosclerosis are manifested in experimental Ca-deficiency.
Koide M, Harayama H, Iio A, Obata K, Matsuda N, Ono T, Yokota M, Tuan R S
Hypertension research : official journal of the Japanese Society of Hypertension   19 Suppl 1 S35-40   Jun 1996   [Refereed]
The eggshell is the major source of Ca required during growth of chick embryos. Therefore, chick embryos placed ex ovo for long-term (SL) are rendered severe systemic calcium deficiency. We report here that SL chick embryos express Ca-deficiency r...

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2010 - 2011    Investigator(s): Koji OBATA
A question of long-standing to cardiac physiologists is whether E-C coupling VO_2 will be really independent of preload. To answer the question, we tried to develop the simultaneous real-time measurement system for myocardial mechanoenergetics and...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2008 - 2009    Investigator(s): Koji OBATA