西脇 理英

J-GLOBALへ         更新日: 17/10/06 03:06
 
アバター
研究者氏名
西脇 理英
所属
岐阜大学
部署
医学系研究科 医科学専攻 分子・構造学講座 薬理病態学分野
職名
助教
学位
医学博士(岐阜大学)
その他の所属
医学系研究科

研究分野

 
 

経歴

 
 
   
 
都立衛生研究所
 
 
   
 
国立がんセンター研究所
 
 
   
 
岐阜大学
 

学歴

 
 
   
 
東京理科大学 薬学部 
 
 
 - 
1992年3月
東京理科大学 大学院薬学研究科修士課程 薬学専攻
 

論文

 
Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Molecular medicine reports   16(3) 2881-2886   2017年9月   [査読有り]
Onuma T, Tanabe K, Kito Y, Tsujimoto M, Uematsu K, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H
Thrombosis research   156 91-100   2017年8月   [査読有り]
Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Molecular medicine reports      2017年8月   [査読有り]
Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H
Experimental and therapeutic medicine   14(1) 417-423   2017年7月   [査読有り]
Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T, Kozawa O
Biochimica et biophysica acta   1863(6) 1629-1639   2017年6月   [査読有り]
Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
International journal of molecular medicine   39(4) 1053-1060   2017年4月   [査読有り]
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
Molecular medicine reports   15(4) 1847-1852   2017年4月   [査読有り]
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Prostaglandins & other lipid mediators   128-129 27-33   2017年1月   [査読有り]
Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T
PloS one   12(5) e0177878   2017年   [査読有り]
Kainuma S, Tokuda H, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T
Biomedical reports   5(6) 771-775   2016年12月   [査読有り]
Gen Kuroyanagi, Gen Kuroyanagi, Takanobu Otsuka, Naohiro Yamamoto, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Akira Nakakami, Jun Mizutani, Osamu Kozawa, Haruhiko Tokuda, Haruhiko Tokuda
International Journal of Molecular Sciences   15 17886-17900   2016年4月
© 2014 by the authors; licensee MDPI, Basel, Switzerland. It is firmly established that resveratrol, a natural food compound abundantly found in grape skins and red wine, has beneficial properties for human health. In the present study, we investi...
αB-crystallin reduces ristocetin‑induced soluble CD40 ligand release in human platelets: Suppression of thromboxane A2 generation.
Tsujimoto M, Doi T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Iida Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T.
Mol Med Rep.   12(1) 357-362   2015年5月   [査読有り]
Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.
Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
Prostaglandins Leukot Essent Fatty Acids.   94 73-81   2015年5月   [査読有り]
Rac limits TGF-β-induced VEGF synthesis in osteoblasts.
Yamamoto N, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
Mol Cell Endocrinol.   405 35-41   2015年4月   [査読有り]
Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration.
Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui,T, Yoshimi N, Kozawa O, Morishige K.
Arch Biochem   57(1) 40-49   2015年2月   [査読有り]
Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: Suppression of stress-activated protein kinase/c-Jun N-terminal kinase.
Yamamoto N, Otsuka T, Kuroyanagi G, Kondo A, Kainuma S, Nakakami A, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Prostaglandins Other Lipid Mediat.   116-117 57-63   2015年1月   [査読有り]
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
Nagasawa T, Matsushima-Nishiwaki R, Yasuda E, Matsuura J, Toyoda H, Kaneoka Y, Kumada T, Kozawa O.
Arch Biochem Biophys.   565 1-8   2015年1月   [査読有り]
Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
Yamamoto N, Tokuda H, Kuroyanagi G, Mizutani J, Matsushima-Nishiwaki R, Kondo A, Kozawa O, Otsuka T.
Int J Mol Med.   34(5) 1439-1445   2014年11月   [査読有り]
Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.
Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A,Mizutani J, Kozawa O, Tokuda H.
Int J Mol Sci.   15(10) 17886-17900   2014年10月   [査読有り]
(-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate‑stimulated human platelet activation: suppression of heat shock protein 27 phosphorylation via p38 mitogen‑activated protein kinase.
Iida Y, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Kozawa O, Iida H.
Mol Med Rep.   10(3) 1383-1388   2014年9月   [査読有り]
Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax.
Nagasawa T, Matsushima-Nishiwaki R, Toyoda H, Matsuura J, KumadaT, Kozawa O.
Oncol Rep.   32(3) 1291-1295   2014年9月   [査読有り]
Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts.
Kuroyanagi G, Mizutani J, Kondo A, Yamamoto N, Matsushima-Nishiwaki R, Otsuka T, Kozawa O, Tokuda H.
Prostaglandins Leukot Essent Fatty Acids.   91(3) 73-80   2014年9月   [査読有り]
Kageyama Yasunari, Doi Tomoaki, Matsushima-Nishiwaki Rie, Iida Yuko, Akamatsu Shigeru, Kondo Akira, Kuroyanagi Gen, Yamamoto Naohiro, Mizutani Jun, Otsuka Takanobu, Tokuda Haruhiko, Iida Hiroki, Kozawa Osamu, Ogura Shinji
Molecular medicine reports   10 107-112   2014年4月   [査読有り]
We have previously shown that glycoprotein Ib/IX/V activation stimulates the release of the soluble CD40 ligand (sCD40L) via the generation of thromboxane A2 from human platelets. In the present study, the role of Rac, which is a member of the Rho...
Kondo Akira, Otsuka Takanobu, Kuroyanagi Gen, Yamamoto Naohiro, Matsushima-Nishiwaki Rie, Mizutani Jun, Kozawa Osamu, Tokuda Haruhiko
International journal of molecular medicine   33(4) 1013-1018   2014年4月   [査読有り]
Resveratrol is well known as a natural polyphenol abundantly found in red wine. We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates vascular endothelial growth factor (VEGF) synthesis via p70 S6 kinase in osteoblast-like MC...
Kondo Akira, Tokuda Haruhiko, Matsushima-Nishiwaki Rie, Kuroyanagi Gen, Yamamoto Naohiro, Mizutani Jun, Kozawa Osamu, Otsuka Takanobu
Life sciences   96(1-2) 18   2014年2月   [査読有り]
We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates the synthesis of osteocalcin via p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, whereas p44/p42 MAP kinase plays as a negative regulator in ...
Gen Kuroyanagi, Gen Kuroyanagi, Jun Mizutani, Akira Kondo, Akira Kondo, Naohiro Yamamoto, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Osamu Kozawa, Haruhiko Tokuda, Haruhiko Tokuda
Prostaglandins Leukotrienes and Essential Fatty Acids   91 73-80   2014年1月
Resveratrol, a natural polyphenol with health-related properties mainly existing in grape skins and red wine, possesses beneficial effects on human being. We have previously reported that prostaglandin D2 (PGD2) stimulates heat shock protein 27 (H...
Naohiro Yamamoto, Naohiro Yamamoto, Haruhiko Tokuda, Haruhiko Tokuda, Gen Kuroyanagi, Gen Kuroyanagi, Jun Mizutani, Rie Matsushima-Nishiwaki, Akira Kondo, Akira Kondo, Osamu Kozawa, Takanobu Otsuka
International Journal of Molecular Medicine   34 1439-1445   2014年1月
Resveratrol is a natural polyphenol found in red grape skins, berries and red wine. Accumulating evidence suggests that resveratrol has various beneficial effects on the human body. In the present study, we investigated the effects of prostaglandi...
Tomoaki Nagasawa, Rie Matsushima-Nishiwaki, Hidenori Toyoda, Junya Matsuura, Takashi Kumada, Osamu Kozawa
Oncology Reports   32 1291-1295   2014年1月
A small heat shock protein (HSP), HSP20 (HSPB6) is ubiquitously expressed in various tissues and has several functions. We previously reported that the expression of HSP20 protein in human hepatocellular carcinoma (HCC) cells is inversely proporti...
Kumiko Tanabe, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida
International Journal of Molecular Medicine   34 1032-1038   2014年1月
Dexmedetomidine, an α<inf>2</inf>-adrenoceptor agonist, is used as a sedative medication for criticalyl ill patients and is known to exert neuroprotective effects by direct action on neurons and indirect action on neurons through astrocytes. Inter...
Yuko Iida, Yuko Iida, Tomoaki Doi, Rie Matsushima-nishiwaki, Haruhiko Tokuda, Haruhiko Tokuda, Shinji Ogura, Osamu Kozawa, Hiroki Iida
Molecular Medicine Reports   10 1383-1388   2014年1月
(-)-Epigallocatechin gallate (EGCG) is a major component of green tea. It has been demonstrated that EGCG has an antithrombotic effect by inhibiting platelet aggregation. However, the detailed mechanisms underlying the effects of EGCG remain to be...
Kuroyanagi Gen, Tokuda Haruhiko, Matsushima-Nishiwaki Rie, Kondo Akira, Mizutani Jun, Kozawa Osamu, Otsuka Takanobu
Archives of biochemistry and biophysics   542 39   2014年1月   [査読有り]
Resveratrol, a natural polyphenol abundantly found in grape skins and red wine, possesses various beneficial properties for human health. In the present study, we investigated the mechanism underlying the effects of prostaglandin F2α (PGF2α) on os...
Kuroyanagi Gen, Otsuka Takanobu, Kondo Akira, Matsushima-Nishiwaki Rie, Mizutani Jun, Kozawa Osamu, Tokuda Haruhiko
Biochimie   95(10) 1933-1938   2013年10月   [査読有り]
We previously reported that interleukin-1 (IL-1), a potent bone resorptive cytokine, stimulates the synthesis of interleukin-6 (IL-6) via activationof p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 ce...
Kondo Akira, Tokuda Haruhiko, Matsushima-Nishiwaki Rie, Kato Kenji, Kuroyanagi Gen, Mizutani Jun, Fukuoka Muneyoshi, Wada Ikuo, Kozawa Osamu, Otsuka Takanobu
Molecular medicine reports   8(2) 691-695   2013年8月   [査読有り]
Heat shock protein 27 (HSP27) also known as heat shock protein β1 (HSPB1) is a member of the family of small heat shock proteins ubiquitously expressed in all tissues. It has previously been demonstrated that HSP27 regulated the synthesis of osteo...
Kondo Akira, Otsuka Takanobu, Matsushima-Nishiwaki Rie, Kuroyanagi Gen, Mizutani Jun, Wada Ikuo, Kozawa Osamu, Tokuda Haruhiko
Archives of biochemistry and biophysics   535(2) 227-233   2013年7月   [査読有り]
Stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK)(1) which belongs to the MAP kinase superfamily regulates many cellular events. We previously reported that interleukin 1 (IL-1) stimulates the synthesis of interleukin 6 (IL-6) thr...
Kondo Akira, Otsuka Takanobu, Kato Kenji, Matsushima-Nishiwaki Rie, Kuroyanagi Gen, Mizutani Jun, Tokuda Haruhiko, Kozawa Osamu
International journal of molecular medicine   31(6) 1457-1462   2013年6月   [査読有り]
AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into th...
Cuong Nguyen The, Doi Tomoaki, Matsushima-Nishiwaki Rie, Akamatsu Shigeru, Kuroyanagi Gen, Kondo Akira, Mizutani Jun, Wada Ikuo, Otsuka Takanobu, Tokuda Haruhiko, Kozawa Osamu, Ogura Shinji
International journal of molecular medicine   31(6) 1291-1297   2013年6月   [査読有り]
It has been shown that thrombopoietin (TPO) amplifies agonist-induced platelet activation. However, the precise mechanism of action of TPO has not yet been fully elucidated. We have previously reported that the adenosine diphosphate (ADP)‑induced ...
Kondo Akira, Tokuda Haruhiko, Kato Kenji, Matsushima-Nishiwaki Rie, Kuroyanagi Gen, Mizutani Jun, Kozawa Osamu, Otsuka Takanobu
Biochimie   95(4) 719-724   2013年4月   [査読有り]
Evidence is accumulating that Rho-associated kinase (Rho-kinase) plays important roles not only in vascular smooth muscle cell contraction, but also in a variety of cellular functions, including bone metabolism. In the present study, we investigat...
Osawa Yosuke, Suetsugu Atsushi, Matsushima-Nishiwaki Rie, Yasuda Ichiro, Saibara Toshiji, Moriwaki Hisataka, Seishima Mitsuru, Kozawa Osamu
The Journal of clinical investigation   123(2) 834-843   2013年2月   [査読有り]
Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). These sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells. However, the rol...
Iida Miki, Tanabe Kumiko, Matsushima-Nishiwaki Rie, Kozawa Osamu, Iida Hiroki
Archives of biochemistry and biophysics   530(2) 83   2013年2月   [査読有り]
Migration of vascular smooth muscle cells (VSMCs) is essential for repair of vascular injury, development of atherosclerotic lesions and restenosis after angioplasty or by-pass graft surgery. It has been reported that platelet-derived growth facto...
Matsushima-Nishiwaki Rie, Kumada Takashi, Nagasawa Tomoaki, Suzuki Mariko, Yasuda Eisuke, Okuda Seiji, Maeda Atsuyuki, Kaneoka Yuji, Toyoda Hidenori, Kozawa Osamu
PloS one   8(11) e78440   2013年   [査読有り]
HSP20 (HSPB6), one of small heat shock proteins (HSPs), is constitutively expressed in various tissues and has several functions. We previously reported that the expression levels of HSP20 in human hepatocellular carcinoma (HCC) cells inversely co...
Kondo Akira, Otsuka Takanobu, Kato Kenji, Natsume Hideo, Kuroyanagi Gen, Mizutani Jun, Ito Yoshiki, Matsushima-Nishiwaki Rie, Kozawa Osamu, Tokuda Haruhiko
International journal of molecular medicine   30(6) 1487-1492   2012年12月   [査読有り]
We previously showed that prostaglandin F(2α) (PGF(2α)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protei...
Tokuda Haruhiko, Kato Kenji, Kasahara Senji, Matsushima-Nishiwaki Rie, Mizuno Takahiko, Sakakibara Seiko, Kozawa Osamu
International journal of molecular medicine   30(6) 1387-1395   2012年12月   [査読有り]
To clarify the mechanism underlying a high risk of thrombotic complications in diabetic patients, we investigated the relationship between HSP27 phosphorylation and the platelet activation induced by adenosine diphosphate (ADP) in diabetic patient...
Tokuda H, Kato K, Natsume H, Kondo A, Kuroyanagi G, Matsushima-Nishiwaki R, Ito Y, Otsuka T, Kozawa O
Journal of molecular endocrinology   49(1) 47   2012年8月   [査読有り]
We previously demonstrated that thrombin stimulates synthesis of interleukin 6 (IL6), a potent bone resorptive agent, in part via p44/p42 MAP kinase and p38 MAP kinase but not through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/J...
Kondo Akira, Tokuda Haruhiko, Mizutani Jun, Matsushima-Nishiwaki Rie, Kozawa Osamu, Otsuka Takanobu
Molecular medicine reports   6(2) 421-425   2012年8月   [査読有り]
It is known that Wnt3a affects bone metabolism via the canonical Wnt/β-catenin signaling pathway. We have previously shown that prostaglandin F2α (PGF2α) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6...
Kato Kenji, Tokuda Haruhiko, Matsushima-Nishiwaki Rie, Natsume Hideo, Kondo Akira, Ito Yoshiki, Kozawa Osamu, Otsuka Takanobu
Cellular signalling   24(8) 1706-1712   2012年8月   [査読有り]
AMP-activated protein kinase (AMPK) is currently known to act as a key regulator of metabolic homeostasis. Several biosynthetic enzymes for fatty acid or glycogen are recognized as the targets of AMPK. In the present study, we investigated the rol...
Tanabe Kumiko, Matsushima-Nishiwaki Rie, Iida Miki, Kozawa Osamu,Iida Hiroki
Brain research   1463 21-29   2012年6月   [査読有り]
Basic fibroblast growth factor (FGF-2) has a neuroprotective effect. Astrocytes support neurons by releasing neurotrophic factors including glial cell line-derived neurotrophic factor (GDNF). FGF-2 stimulates GDNF synthesis in astrocytes and the r...
Mizutani Jun, Tokuda Haruhiko, Matsushima-Nishiwaki Rie, Kato Kenji, Kondo Akira, Natsume Hideo, Kozawa Osamu, Otsuka Takanobu
International journal of molecular medicine   29(4) 550-556   2012年4月   [査読有り]
It is generally recognized that AMP-activated protein kinase (AMPK) acts as a key regulator of energy homeostasis. We have previously shown that transforming growth factor-β (TGF-β) stimulates synthesis of vascular endothelial growth factor (VEGF)...
Kato Kenji, Otsuka Takanobu, Kondo Akira, Matsushima-Nishiwaki Rie, Natsume Hideo, Kozawa Osamu, Tokuda Haruhiko
Life sciences   90(1-2) 71-76   2012年1月   [査読有り]
We have previously reported that platelet-derived growth factor (PDGF)-BB stimulates synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells, and that the activation of p44/p42 mitogen-activated protein...
Nakashima Masanori, Adachi Seiji, Yasuda Ichiro, Yamauchi Takahiro, Kawaguchi Junji, Itani Masahiko, Yoshioka Takashi, Matsushima-Nishiwaki Rie, Hirose Yoshinobu, Kozawa Osamu, Moriwaki Hisataka
Cancer letters   313(2) 218-225   2011年12月   [査読有り]
Gemcitabine, an antitumor drug, is currently considered to be the standard of care for the treatment of advanced pancreatic cancer, but the clinical outcome is still not satisfactory. Although heat shock protein (HSP) 27 is implicated in the resis...
Kato Kenji, Tokuda Haruhiko, Mizutani Jun, Adachi Seiji, Matsushima-Nishiwaki Rie, Natsume Hideo, Kozawa Osamu, OtsukaTakanobu
International journal of molecular medicine   28(5) 887-893   2011年11月   [査読有り]
Heat shock protein 27 (HSP27) is known to act as a molecular chaperone. We have recently reported that HSP27 regulates osteocalcin synthesis in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the role of HSP27 in tumor necros...

Misc

 
Moriwaki Hisataka, Shimizu Masahito, Okuno Masataka, Nishiwaki-Matsushima Rie
Hepatology research : the official journal of the Japan Society of Hepatology   37 Suppl 2 S299-S302   2007年9月   [査読有り]
The strategy to prevent liver carcinogenesis consists of: (i) antiviral modalities such as vaccination, lamivudin, and interferon; (ii) anti-inflammatory modality; and (iii) chemoprevention using such compounds as retinoid analog and vitamin K. Ca...
Retinoids in cancer chemoprevention.
Okuno Masataka, Kojima Soichi, Matsushima-Nishiwaki Rie, Tsurumi Hisashi, Muto Yasutoshi, Friedman Scott L, Moriwaki Hisataka
Current cancer drug targets   4(3) 285-298   2004年5月   [査読有り]
We review the therapeutic and preventive applications of a retinoid analog (vitamin A and its derivatives) for human cancers. Chemoprevention of cancer is an intervention in the carcinogenic process by chemical agents that block or reverse the mal...
Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).
Kojima Soichi, Okuno Masataka, Matsushima-Nishiwaki Rie, Friedman Scott L, Moriwaki Hisataka
International journal of oncology   24(4) 797-798   2004年4月   [査読有り]
We here review therapeutic application of a synthetic analog of retinoids (vitamin A and its derivatives), named acyclic retinoid (AR), towards chemoprevention of hepatocellular carcinoma (HCC), and its underlying molecular mechanisms. A high inci...
Rie Nishiwaki, Masataka Okuno, Hisataka Moriwaki
Nippon rinsho. Japanese journal of clinical medicine   62 Suppl 12 141-144   2004年1月   [査読有り]
Masataka Okuno, Rie Nishiwaki, Hisataka Moriwaki
Nippon rinsho. Japanese journal of clinical medicine   62 Suppl 12 134-137   2004年1月
Retinoids in liver fibrosis and cancer.
Okuno Masataka, Kojima Soichi, Akita Kuniharu, Matsushima-Nishiwaki Rie, Adachi Seiji, Sano Tetsuro, Takano Yukihiko, Takai Koji, Obora Akihiro, Yasuda Ichiro, Shiratori Yoshimune, Okano Yukio, Shimada Jun, Suzuki Yasuhiro, Muto Yasutoshi, Moriwaki Yasutoshi
Frontiers in bioscience : a journal and virtual library   7 d204-d218   2002年1月   [査読有り]
Pathobiological functions and metabolism of retinoids (vitamin A and its derivatives) in liver fibrosis and hepatocellular carcinoma (HCC) are discussed in the present review. Retinoic acid (RA, active metabolite) exacerbates liver fibrosis that i...
R. Nishiwaki, M. Okuno, Y. Shiratori, H. Moriwaki
Nippon rinsho. Japanese journal of clinical medicine   57 Suppl 117-120   1999年1月
H. Moriwaki, M. Okuno, R. Nishiwaki, Y. Shiratori
Nippon rinsho. Japanese journal of clinical medicine   57 Suppl 279-281   1999年1月
Y. Shiratori, H. Moriwaki, R. Nishiwaki, M. Okuno
Nippon rinsho. Japanese journal of clinical medicine   57 Suppl 79-82   1999年1月   [査読有り]
M. Okuno, R. Nishiwaki, Y. Shiratori, H. Moriwaki
Nippon rinsho. Japanese journal of clinical medicine   57 Suppl 121-124   1999年1月   [査読有り]
Mechanisms of action of new antitumor promoters.
Suganuma M, Yoshizawa S, Yatsunami J, Nishiwaki S, Furuya H, Okabe S, Nishiwaki-Matsushima R, Frenkel K, Troll W, Verma A K
Basic life sciences   61 317-323   1993年   [査読有り]
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway.
Fujiki H, Suganuma M, Nishiwaki S, Yoshizawa S, Yatsunami J, Matsushima R, Furuya H, Okabe S, Matsunaga S, Sugimura T
Progress in clinical and biological research   374 337-350   1992年   [査読有り]
Marine natural products against tumor development.
Yatsunami J, Fujiki H, Komori A, Suganuma M, Nishiwaki S, Okabe S, Nishiwaki-Matsushima R, Ohta T, Matsunaga S, Fusetani N
Journal of nutritional science and vitaminology   Spec No 333-336   1992年   [査読有り]
This review article deals with significant effects of marine natural products in carcinogenesis, namely as chemical probes to understand the process of carcinogenesis and as possible cancer preventive agents in humans.

講演・口頭発表等

 
肝癌細胞増殖におけるHSP20の役割:MAP kinase およびAKTシグナル経路の抑制
西脇 理英、永澤 友章、安田 鋭介、豊田 秀徳、熊田 卓、小澤 修
第73回日本癌学会学術集会   2014年9月   日本がん学会