Onuma T, Tanabe K, Kito Y, Tsujimoto M, Uematsu K, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H
Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
Molecular medicine reports 10(1) 107-112 2014年4月 [査読有り]
We have previously shown that glycoprotein Ib/IX/V activation stimulates the release of the soluble CD40 ligand (sCD40L) via the generation of thromboxane A2 from human platelets. In the present study, the role of Rac, which is a member of the Rho...
International journal of molecular medicine 33(4) 1013-1018 2014年4月 [査読有り]
Resveratrol is well known as a natural polyphenol abundantly found in red wine. We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates vascular endothelial growth factor (VEGF) synthesis via p70 S6 kinase in osteoblast-like MC...
We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates the synthesis of osteocalcin via p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, whereas p44/p42 MAP kinase plays as a negative regulator in ...
Gen Kuroyanagi, Gen Kuroyanagi, Jun Mizutani, Akira Kondo, Akira Kondo, Naohiro Yamamoto, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Osamu Kozawa, Haruhiko Tokuda, Haruhiko Tokuda
Prostaglandins Leukotrienes and Essential Fatty Acids 91(3) 73-80 2014年1月
Resveratrol, a natural polyphenol with health-related properties mainly existing in grape skins and red wine, possesses beneficial effects on human being. We have previously reported that prostaglandin D2 (PGD2) stimulates heat shock protein 27 (H...
Naohiro Yamamoto, Naohiro Yamamoto, Haruhiko Tokuda, Haruhiko Tokuda, Gen Kuroyanagi, Gen Kuroyanagi, Jun Mizutani, Rie Matsushima-Nishiwaki, Akira Kondo, Akira Kondo, Osamu Kozawa, Takanobu Otsuka
International Journal of Molecular Medicine 34(5) 1439-1445 2014年1月
Resveratrol is a natural polyphenol found in red grape skins, berries and red wine. Accumulating evidence suggests that resveratrol has various beneficial effects on the human body. In the present study, we investigated the effects of prostaglandi...
A small heat shock protein (HSP), HSP20 (HSPB6) is ubiquitously expressed in various tissues and has several functions. We previously reported that the expression of HSP20 protein in human hepatocellular carcinoma (HCC) cells is inversely proporti...
International Journal of Molecular Medicine 34(4) 1032-1038 2014年1月
Dexmedetomidine, an α<inf>2</inf>-adrenoceptor agonist, is used as a sedative medication for criticalyl ill patients and is known to exert neuroprotective effects by direct action on neurons and indirect action on neurons through astrocytes. Inter...
Molecular Medicine Reports 10(3) 1383-1388 2014年1月
(-)-Epigallocatechin gallate (EGCG) is a major component of green tea. It has been demonstrated that EGCG has an antithrombotic effect by inhibiting platelet aggregation. However, the detailed mechanisms underlying the effects of EGCG remain to be...
Archives of biochemistry and biophysics 542 39-45 2014年1月 [査読有り]
Resveratrol, a natural polyphenol abundantly found in grape skins and red wine, possesses various beneficial properties for human health. In the present study, we investigated the mechanism underlying the effects of prostaglandin F2α (PGF2α) on os...
We previously reported that interleukin-1 (IL-1), a potent bone resorptive cytokine, stimulates the synthesis of interleukin-6 (IL-6) via activationof p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 ce...
Molecular medicine reports 8(2) 691-695 2013年8月 [査読有り]
Heat shock protein 27 (HSP27) also known as heat shock protein β1 (HSPB1) is a member of the family of small heat shock proteins ubiquitously expressed in all tissues. It has previously been demonstrated that HSP27 regulated the synthesis of osteo...
Archives of biochemistry and biophysics 535(2) 227-233 2013年7月 [査読有り]
Stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK)(1) which belongs to the MAP kinase superfamily regulates many cellular events. We previously reported that interleukin 1 (IL-1) stimulates the synthesis of interleukin 6 (IL-6) thr...
International journal of molecular medicine 31(6) 1457-1462 2013年6月 [査読有り]
AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into th...
International journal of molecular medicine 31(6) 1291-1297 2013年6月 [査読有り]
It has been shown that thrombopoietin (TPO) amplifies agonist-induced platelet activation. However, the precise mechanism of action of TPO has not yet been fully elucidated. We have previously reported that the adenosine diphosphate (ADP)‑induced ...
Evidence is accumulating that Rho-associated kinase (Rho-kinase) plays important roles not only in vascular smooth muscle cell contraction, but also in a variety of cellular functions, including bone metabolism. In the present study, we investigat...
The Journal of clinical investigation 123(2) 834-843 2013年2月 [査読有り]
Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). These sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells. However, the rol...
Archives of biochemistry and biophysics 530(2) 83-92 2013年2月 [査読有り]
Migration of vascular smooth muscle cells (VSMCs) is essential for repair of vascular injury, development of atherosclerotic lesions and restenosis after angioplasty or by-pass graft surgery. It has been reported that platelet-derived growth facto...
HSP20 (HSPB6), one of small heat shock proteins (HSPs), is constitutively expressed in various tissues and has several functions. We previously reported that the expression levels of HSP20 in human hepatocellular carcinoma (HCC) cells inversely co...
International journal of molecular medicine 30(6) 1487-1492 2012年12月 [査読有り]
We previously showed that prostaglandin F(2α) (PGF(2α)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protei...
International journal of molecular medicine 30(6) 1387-1395 2012年12月 [査読有り]
To clarify the mechanism underlying a high risk of thrombotic complications in diabetic patients, we investigated the relationship between HSP27 phosphorylation and the platelet activation induced by adenosine diphosphate (ADP) in diabetic patient...
Tokuda H, Kato K, Natsume H, Kondo A, Kuroyanagi G, Matsushima-Nishiwaki R, Ito Y, Otsuka T, Kozawa O
Journal of molecular endocrinology 49(1) 47-55 2012年8月 [査読有り]
We previously demonstrated that thrombin stimulates synthesis of interleukin 6 (IL6), a potent bone resorptive agent, in part via p44/p42 MAP kinase and p38 MAP kinase but not through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/J...
Molecular medicine reports 6(2) 421-425 2012年8月 [査読有り]
It is known that Wnt3a affects bone metabolism via the canonical Wnt/β-catenin signaling pathway. We have previously shown that prostaglandin F2α (PGF2α) stimulates the synthesis of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6...
AMP-activated protein kinase (AMPK) is currently known to act as a key regulator of metabolic homeostasis. Several biosynthetic enzymes for fatty acid or glycogen are recognized as the targets of AMPK. In the present study, we investigated the rol...
Basic fibroblast growth factor (FGF-2) has a neuroprotective effect. Astrocytes support neurons by releasing neurotrophic factors including glial cell line-derived neurotrophic factor (GDNF). FGF-2 stimulates GDNF synthesis in astrocytes and the r...
International journal of molecular medicine 29(4) 550-556 2012年4月 [査読有り]
It is generally recognized that AMP-activated protein kinase (AMPK) acts as a key regulator of energy homeostasis. We have previously shown that transforming growth factor-β (TGF-β) stimulates synthesis of vascular endothelial growth factor (VEGF)...
We have previously reported that platelet-derived growth factor (PDGF)-BB stimulates synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells, and that the activation of p44/p42 mitogen-activated protein...
Gemcitabine, an antitumor drug, is currently considered to be the standard of care for the treatment of advanced pancreatic cancer, but the clinical outcome is still not satisfactory. Although heat shock protein (HSP) 27 is implicated in the resis...
International journal of molecular medicine 28(5) 887-893 2011年11月 [査読有り]
Heat shock protein 27 (HSP27) is known to act as a molecular chaperone. We have recently reported that HSP27 regulates osteocalcin synthesis in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the role of HSP27 in tumor necros...
Hepatology research : the official journal of the Japan Society of Hepatology 37 Suppl 2 S299-S302 2007年9月 [査読有り]
The strategy to prevent liver carcinogenesis consists of: (i) antiviral modalities such as vaccination, lamivudin, and interferon; (ii) anti-inflammatory modality; and (iii) chemoprevention using such compounds as retinoid analog and vitamin K. Ca...
Okuno Masataka, Kojima Soichi, Matsushima-Nishiwaki Rie, Tsurumi Hisashi, Muto Yasutoshi, Friedman Scott L, Moriwaki Hisataka
Current cancer drug targets 4(3) 285-298 2004年5月 [査読有り]
We review the therapeutic and preventive applications of a retinoid analog (vitamin A and its derivatives) for human cancers. Chemoprevention of cancer is an intervention in the carcinogenic process by chemical agents that block or reverse the mal...
Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).
Kojima Soichi, Okuno Masataka, Matsushima-Nishiwaki Rie, Friedman Scott L, Moriwaki Hisataka
International journal of oncology 24(4) 797-798 2004年4月 [査読有り]
We here review therapeutic application of a synthetic analog of retinoids (vitamin A and its derivatives), named acyclic retinoid (AR), towards chemoprevention of hepatocellular carcinoma (HCC), and its underlying molecular mechanisms. A high inci...
Frontiers in bioscience : a journal and virtual library 7 d204-d218 2002年1月 [査読有り]
Pathobiological functions and metabolism of retinoids (vitamin A and its derivatives) in liver fibrosis and hepatocellular carcinoma (HCC) are discussed in the present review. Retinoic acid (RA, active metabolite) exacerbates liver fibrosis that i...
Nippon rinsho. Japanese journal of clinical medicine 57 Suppl 121-124 1999年1月 [査読有り]
Mechanisms of action of new antitumor promoters.
Suganuma M, Yoshizawa S, Yatsunami J, Nishiwaki S, Furuya H, Okabe S, Nishiwaki-Matsushima R, Frenkel K, Troll W, Verma A K
Basic life sciences 61 317-323 1993年 [査読有り]
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway.
Fujiki H, Suganuma M, Nishiwaki S, Yoshizawa S, Yatsunami J, Matsushima R, Furuya H, Okabe S, Matsunaga S, Sugimura T
Progress in clinical and biological research 374 337-350 1992年 [査読有り]
Marine natural products against tumor development.
Yatsunami J, Fujiki H, Komori A, Suganuma M, Nishiwaki S, Okabe S, Nishiwaki-Matsushima R, Ohta T, Matsunaga S, Fusetani N
Journal of nutritional science and vitaminology Spec No 333-336 1992年 [査読有り]
This review article deals with significant effects of marine natural products in carcinogenesis, namely as chemical probes to understand the process of carcinogenesis and as possible cancer preventive agents in humans.
