IIMURA Tadahiro

J-GLOBAL         Last updated: Apr 1, 2019 at 14:54
IIMURA Tadahiro
Hokkaido University
Job title

Research Areas


Academic & Professional Experience

Mar 2019
Professor, Graduate School of Dental Medicine, Hokkaido Univeristy
Apr 2016
Feb 2019
Professor, Graduate School of Medicine, Ehime University
Apr 2015
Feb 2019
Professor, Advanced Research Support Center (ADRES), Ehime University
Jan 2015
Feb 2019
Professor, Proteo-Science Center (PROS), Ehime University
Apr 2013
Dec 2014
Associate Professor, Proteo-Science Center, Ehime University
Jan 2009
Mar 2013
Associate Professor, Global COE, Tokyo Medical and Dental Univeristy
Apr 2008
Dec 2008
Dec 2004
Mar 2008
Senior Research Associate, Olivier Pourquie Lab., Stowers Institute for Medical Research
Aug 2002
Nov 2004
Research Associate, Olivier Pourquie Lab., Stowers Institute for Medical Research
Nov 2000
Jul 2002
Researcher, Olivier Pourquie Lab., Developmental Biology Insistute in Marseille
Jun 1996
Jul 2004
Assistant Professor, Department of Molecular Embryology, Tokyo Medical and Dental Univeristy
Jul 1995
May 1996
JSPS Special Research Fellow PD, Faculty of Dentistry, Department of Biochemistry, Tokyo Medical and Dental University
Apr 1995
Jun 1995
Faculty of Dentistry, Department of Biochemistry, Tokyo Medical and Dental Univeristy
Apr 1992
Mar 1995
JSPS Special Research Fellow DC1, Faculty of Dentistry, Department of Biochemistry, Tokyo Medical and Dental University


Apr 1991
Mar 1995
Department of Biochemistry, Graduate School of Dentistry, Tokyo Medical and Dental University
Apr 1984
Mar 1991
School of Dentistry, Faculty of Dentistry, Hokkaido University

Awards & Honors

Jul 2018
Academic Award, Japanese Society for Bone and Mineral Research
Sep 2010
Academic Award, Japanese Association for Oral Biology
May 2008
Most Down-Loaded Paper Award, Japanese Society for Developmental Biologists
Mar 1999
Hatton Travel Award, International Association for Dental Research

Published Papers

Ishimaru Y, Oshima Y, Imai Y, Iimura T, Takanezawa S, Hino K, Miura H
Molecules   23(23) pii: E3081   Nov 2018   [Refereed]
Bone mineral density (BMD) is a commonly used diagnostic indicator for bone fracture risk in osteoporosis. Along with low BMD, bone fragility accounts for reduced bone quality in addition to low BMD, but there is no diagnostic method to directly a...
Morita, M., Nagaoka, H., Ntege, E. H., Kanoi, B. N., Ito, D., Nakata, T., Lee, J. W., Tokunaga, K., Iimura, T., Torii, M., Tsuboi, T., and Takashima, E.
Sci Rep   8(1) 3696   Feb 2018   [Refereed]
Upon invasion, Plasmodium falciparum exports hundreds of proteins across its surrounding parasitophorous vacuole membrane (PVM) to remodel the infected erythrocyte. Although this phenomenon is crucial for the parasite growth and virulence, elucida...
Yamashita, M., Inoue, K., Saeki, N., Ideta-Otsuka, M., Yanagihara, Y., Sawada, Y., Sakakibara, I., Lee, J., Ichikawa, K., Kamei, Y., Iimura, T., Igarashi, K., Takada, Y., and Imai, Y.
Development   145(1) dev157412   Jan 2018   [Refereed]
Transcriptional regulation can be tightly orchestrated by epigenetic regulators. Among these, ubiquitin-like with PHD and RING finger domains 1 (Uhrf1) is reported to have diverse epigenetic functions, including regulation of DNA methylation. Howe...
Lee, J. W., Hoshino, A., Inoue, K., Saitou, T., Uehara, S., Kobayashi, Y., Ueha, S., Matsushima, K., Yamaguchi, A., Imai, Y., and Iimura, T.
Nat Commun   8(1) 2226   Dec 2017   [Refereed]
C-C chemokine receptor 5 (CCR5) is a co-receptor of HIV. Epidemiological findings suggest that the functional loss of CCR5 is correlated with a lower incidence of bone-destructive diseases as well as of HIV transmission. However, it is not clear w...
Yamane, H., Takakura, A., Shimadzu, Y., Kodama, T., Lee, J. W., Isogai, Y., Ishizuya, T., Takao-Kawabata, R., and Iimura, T.
PLoS One   12(4) e0175329   Apr 2017   [Refereed]
Teriparatide [human parathyroid hormone (1-34)], which exerts an anabolic effect on bone, is used for the treatment of osteoporosis in patients who are at a high risk for fracture. That the once-daily administration of teriparatide causes an incre...
Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N, Udagawa N
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   32(10) 2074-2086   Oct 2017   [Refereed]
Takakura, A., Lee, J. W., Hirano, K., Isogai, Y., Ishizuya, T., Takao-Kawabata, R., and Iimura, T.
Bone Res   5 17002   Apr 2017   [Refereed]
To investigate whether the administration frequency of parathyroid hormone (PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1-34), TPTD] with four distinct concentr...
Lee JW, Iimura T
Jpn Dent Sci Rev.   53(53) 2-10   Feb 2017   [Refereed][Invited]
Digitalized fluorescence images contain numerical information such as color (wavelength), fluorescence intensity and spatial position. However, quantitative analyses of acquired data and their validation remained to be established. Our research gr...
Kenji Ogura, Kenji Ogura, Tadahiro Iimura, Yuji Makino, Ayano Sugie-Oya, Aya Takakura, Ryoko Takao-Kawabata, Toshinori Ishizuya, Keiji Moriyama, Akira Yamaguchi, Akira Yamaguchi
Bone Reports   5 7-14   Dec 2016   [Refereed]
© 2016 The Authors. Intermittent administration of human parathyroid hormone (1-34)[hPTH(1-34)] induces anabolic action on the bones. To understand the mechanism underlying the early phase of hPTH(1-34)-induced anabolic action, we investigated the...
Atsuhiko Hikita, Atsuhiko Hikita, Atsuhiko Hikita, Atsuhiko Hikita, Tadahiro Iimura, Tadahiro Iimura, Yusuke Oshima, Yusuke Oshima, Yusuke Oshima, Yusuke Oshima, Takashi Saitou, Takashi Saitou, Shin Yamamoto, Shin Yamamoto, Takeshi Imamura, Takeshi Imamura, Takeshi Imamura, Takeshi Imamura
Bone   76 5-17   Jul 2015   [Refereed]
© 2015 Elsevier Inc. Bone modeling and remodeling are cellular events during which osteoblast lineage cells and osteoclasts interact. During these events, cells undergo drastic changes with time as they become differentiated. Their morphology, top...
Lee JW, Asai M, Jeon SK, Iimura T, Yonezawa T, Cha BY, Woo JT, Yamaguchi A
Molecular nutrition & food research   59(3) 386-400   Mar 2015   [Refereed]
[Bone Cell Biology Assessed by Microscopic Approach. An application of two-photon microscopy for histopathological analysis of bone and cartilage].
Iimura T
Clinical calcium   25(10) 1513-1520   Oct 2015   [Refereed]
Denans N, Iimura T, Pourquié O
eLife   4    Feb 2015   [Refereed]
Kiyomatsu H, Oshima Y, Saitou T, Miyazaki T, Hikita A, Miura H, Iimura T, Imamura T
Biomedical optics express   6(2) 405-420   Feb 2015   [Refereed]
Ji Won Lee, Tadahiro Iimura, Tadahiro Iimura, Tadahiro Iimura
Journal of Oral Biosciences   57 76-79   Jan 2015   [Refereed]
© 2015 Japanese Association for Oral Biology. Background With colorful and high-contrast images, fluorescence imaging has long been a powerful tool used to confirm existing hypotheses or ideas suggested by other experimental approaches. Highlight ...
Koga S, Oshima Y, Honkura N, Iimura T, Kameda K, Sato K, Yoshida M, Yamamoto Y, Watanabe Y, Hikita A, Imamura T
Cancer science   105(10) 1299-1306   Oct 2014   [Refereed]
Zayar Lin, , Tadahiro Iimura, Tadahiro Iimura, Tadahiro Iimura, Shohei Kasugai, Shohei Kasugai, Akira Yamaguchi, Akira Yamaguchi, Akira Yamaguchi
Journal of Oral Biosciences   57 118-123   Jan 2015   [Refereed]
© 2015 Japanese Association for Oral Biology. Objective Transplantation of non-osteogenic cells that express osteoinductive factors is a potential strategy for cell-mediated bone regenerative therapy. In this study, we investigated the effects of ...
Yusuke Oshima, Yusuke Oshima, Yusuke Oshima, Tadahiro Iimura, Tadahiro Iimura, Takashi Saitou, Takashi Saitou, Takeshi Imamura, Takeshi Imamura, Takeshi Imamura
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   9303    Jan 2015
Osteoporosis is a major bone disease that connotes the risk of fragility fractures resulting from alterations to bone quantity and/or quality to mechanical competence. Bone strength arises from both bone quantity and quality. Assessment of bone qu...
Nishiyama Y, Matsumoto T, Lee JW, Saitou T, Imamura T, Moriyama K, Yamaguchi A, Iimura T
Archives of oral biology   60(1) 45-54   Jan 2015   [Refereed]
Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Goseki-Sone M
The Journal of nutritional biochemistry   24(6) 1000-1007   Jun 2013   [Refereed]
Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y, Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T
Bone   53(1) 248-258   Mar 2013   [Refereed]
Sugiyama M, Saitou T, Kurokawa H, Sakaue-Sawano A, Imamura T, Miyawaki A, Iimura T
PLoS computational biology   10(12) e1003957   Dec 2014   [Refereed]
Watanabe T, Tamamura Y, Hoshino A, Makino Y, Kamioka H, Amagasa T, Yamaguchi A, Iimura T
Bone   51(3) 447-458   Sep 2012   [Refereed]
Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T
Journal of cell science   126(Pt 4) 1032-1045   Feb 2013   [Refereed]
Umehara K, Iimura T, Sakamoto K, Lin Z, Kasugai S, Igarashi Y, Yamaguchi A
Anatomical record (Hoboken, N.J. : 2007)   295(8) 1327-1335   Aug 2012   [Refereed]
Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A
Biochemical and biophysical research communications   424(3) 456-461   Aug 2012   [Refereed]
[Intravital optical imaging of bone and cartilage tissues].
Imamura T, Hikita A, Oshima Y, Iimura T
Clinical calcium   23(12) 1767-1773   Dec 2013   [Refereed]
Iimura T, Nakane A, Sugiyama M, Sato H, Makino Y, Watanabe T, Takagi Y, Numano R, Yamaguchi A
Journal of bone and mineral metabolism   30(3) 254-269   May 2012   [Refereed]
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
Mechanisms of development   129(1-4) 38-50   Mar 2012   [Refereed]
Yuji Makinoa, Yuji Makinoa, Kazuo Kanekob, Akira Yamaguchia, Tadahiro Iimura, Tadahiro Iimura, Tadahiro Iimura
Journal of Oral Biosciences   55 175-179   Nov 2013   [Refereed]
Skeletal patterningistightlylinkedtoembryonicmorphogenesis. Accumulatedevidenceongenotype- phenotype analysesinmodelanimalsandhumanhasuncoveredmolecularsignalsthatparticipate in skeletalsize,shape,andspatialorganization. Embryonicmorphogenesisendo...
Cao L, Moriishi T, Miyazaki T, Iimura T, Hamagaki M, Nakane A, Tamamura Y, Komori T, Yamaguchi A
Journal of bone and mineral metabolism   29(6) 662-670   Nov 2011   [Refereed]
Himeno-Ando A, Izumi Y, Yamaguchi A, Iimura T
Biochemical and biophysical research communications   417(2) 765-770   Jan 2012   [Refereed]
Sato K, Lee JW, Sakamoto K, Iimura T, Kayamori K, Yasuda H, Shindoh M, Ito M, Omura K, Yamaguchi A
The American journal of pathology   182(5) 1890-1899   May 2013   [Refereed]
Shimozono S, Iimura T, Kitaguchi T, Higashijima S, Miyawaki A
Nature   496(7445) 363-366   Apr 2013   [Refereed]
Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K
The Journal of biological chemistry   285(37) 28826-28837   Sep 2010   [Refereed]
Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A
The American journal of pathology   176(2) 968-980   Feb 2010   [Refereed]
Sugiyama M, Sakaue-Sawano A, Iimura T, Fukami K, Kitaguchi T, Kawakami K, Okamoto H, Higashijima S, Miyawaki A
Proceedings of the National Academy of Sciences of the United States of America   106(49) 20812-20817   Dec 2009   [Refereed]
Iimura T, Denans N, Pourquié O
Current topics in developmental biology   88 201-234   2009   [Refereed]
Maroto M, Iimura T, Dale JK, Bessho Y
Advances in experimental medicine and biology   638 124-139   2008   [Refereed]
Iimura T, Pourquié O
Methods in cell biology   87 257-270   2008   [Refereed]
Iimura T, Pourquié O
Development, growth & differentiation   49(4) 265-275   May 2007   [Refereed]
Iimura T, Yang X, Weijer CJ, Pourquié O
Proceedings of the National Academy of Sciences of the United States of America   104(8) 2744-2749   Feb 2007   [Refereed]
Tadahiro Iimura, Tadahiro Iimura, Mayu Sugiyama, Mayu Sugiyama, Mayu Sugiyama, Takashi Watanabe, Takashi Watanabe, Takashi Watanabe, Ayako Nakane, Ayako Nakane, Ayako Nakane, Yuji Makino, Yuji Makino, Akira Yamaguchi, Akira Yamaguchi
Journal of Oral Biosciences   53 97-108   Jun 2011   [Refereed]
Skeletal development and bone homeostasis are dynamic but coordinated cellular process that involves proliferation, migration and differentiation. Molecular biology and genome science promoted this realm of biomedical science by elucidating cell l...
Iimura T, Pourquié O
Nature   442(7102) 568-571   Aug 2006   [Refereed]
Tadahiro Iimura, Tadahiro Iimura, Akiko Himeno, Akiko Himeno, Akiko Himeno, Ayako Nakane, Ayako Nakane, Ayako Nakane, Akira Yamaguchi, Akira Yamaguchi
Journal of Oral Biosciences   52 155-163   Dec 2010   [Refereed]
A set of Hox genes expressed during the embryonic process presents a crucial system to set up the body plan in animal phyla. Current systematic approaches, such as bio-imaging, epigenetic regulation and phylogenetic genome comparison, illuminated ...
Goseki-Sone M, Yamada A, Hamatani R, Mizoi L, Iimura T, Ezawa I
Biochemical and biophysical research communications   299(3) 395-399   Dec 2002   [Refereed]
Yamada A, Maruoka Y, Asahi K, Iimura T, Oida S, Ezawa I, Goseki-Sone M
Journal of nutritional science and vitaminology   48(3) 238-241   Jun 2002   [Refereed]
Onset of the segmentation clock in the chick embryo: evidence for oscillations in the somite precursors in the primitive streak.
Jouve C, Iimura T, Pourquie O
Development (Cambridge, England)   129(5) 1107-1117   Mar 2002   [Refereed]
K. Kubota, K. Kubota, S. Iseki, S. Kuroda, S. Oida, T. Iimura, W. R. Duarte, K. Ohya, I. Ishikawa, S. Kasugai
Bone   31(4) 465-471   Oct 2002   [Refereed]
Bone morphogenetic protein family members (BMPs) are essential signaling molecules during limb development and, in this process, fibroblast growth factor family members (FGFs) cooperate with BMPs. FGFs also exert anabolic effects in bone when syst...
Hidetaka Miyazaki, Hidetaka Miyazaki, Mitsugu Fukuda, Yasushi Ishijima, Yohko Takagi, Tadahiro Iimura, Akihide Negishi, Renzo Hirayama, Naoshi Ishikawa, Teruo Amagasa, Narimichi Kimura, Narimichi Kimura
Clinical Cancer Research   5 4301-4307   Dec 1999
The metastasis suppressor activity of nm23/nucleoside diphosphate (NDP) kinase was assessed using human oral squamous cell carcinoma (SCC) cell lines. When the expression of nm23/NDP kinase was compared among several SCC cell lines, nm23-H2/NDP ki...
Wagner Rodrigues Duarte, Wagner Rodrigues Duarte, Wagner Rodrigues Duarte, Wagner Rodrigues Duarte, Yuko Mikuni-Takagaki, Toshio Kawase, Tadahiro Iimura, Shinichiro Oida, Keiichi Ohya, Keizo Takenaga, Isao Ishikawa, Shohei Kasugai
Journal of Medical and Dental Sciences   46 117-122   Dec 1999   [Refereed]
The periodontal ligament (PDL) functions under constant mechanical stress, and PDL cells obviously control PDL functions under such conditions. We have previously found that the mRNA expression of the Ca 2+-binding protein S100A4 and β-actin is hi...
Masae Goseki-Sone, Asako Yamada, Kumiko Asahi, Arisa Hirota, Ikuko Ezawa, Tadahiro Iimura
Biochemical and Biophysical Research Communications   265 24-28   Nov 1999   [Refereed]
Alkaline phosphatases (ALP) are highly ubiquitous enzymes present in the majority of animals from bacteria to higher vertebrate. Although their wide distribution in nature has suggested that these enzymes should perform important biological functi...
S. Kuroda, S. Kasugai, S. Oida, T. Iimura, K. Ohya, T. Ohyama
Bone   25 431-437   Oct 1999   [Refereed]
Fibroblast growth factor 4 (FGF4), a member of the FGF family, plays several important roles in bone development during embryogenesis. Systemic administration of FGF4 increases bone mass in rats, which suggests the potential therapeutic usefulness...
Hisashi Watanabe, Hisashi Watanabe, Masae Goseki-Sone, Tadahiro Iimura, Shinichiro Oida, Hideo Orimo, Isao Ishikawa
Journal of Periodontology   70 688-691   Jun 1999   [Refereed]
Hypophosphatasia (HOPS) is an inherited disorder characterized by the defect of skeletal mineralization due to tissue-nonspecific alkaline phosphatase (TNSALP) deficiency. In this study we analyzed the THSALP gene from a Japanese patient with HOPS...
Wagner R. Duarte, Wagner R. Duarte, Tadahiro Iimura, Keizo Takenaga, Keiichi Ohya, Isao Ishikawa, Shohei Kasugai
Biochemical and Biophysical Research Communications   255 416-420   Feb 1999   [Refereed]
S100A4 is a member of the S100 calcium-binding protein family. S100A4 is expressed in several tissues; however, it is secreted by few cell types and its extracellular roles are unknown. In the present study we showed by in situ hybridization that ...
M. Goseki-Sone, T. Iimura, K. Takeda, A. Nifuji, Y. Ogata, M. Yanagishita, S. Oida
Calcified Tissue International   64 160-162   Feb 1999   [Refereed]
Tissue-nonspecific-type alkaline phosphatase (TNSALP) is found in the bone, liver, kidney, and other tissues, and its gene consists of 12 exons with the coding sequence beginning in the second exon. Recently, a noncoding first exon was identified ...
Masae Goseki-Sone, Masae Goseki-Sone, Hideo Orimo, Tadahiro Iimura, Hidetaka Miyazaki, Kimimitsu Oda, Hisanobu Shibata, Masaki Yanagishita, Yuzo Takagi, Hisashi Watanabe, Takashi Shimada, Shinichiro Oida
Journal of Bone and Mineral Research   13 1827-1834   Dec 1998   [Refereed]
Hypophosphatasia (HOPS) is an inherited disorder characterized by defects in skeletal mineralization due to the deficiency of tissue- nonspecific alkaline phosphatase (TNSALP). To date, various mutations in the TNSALP gene have been identified. Es...
W. R. Duarte, S. Kasugai, T. Iimura, S. Oida, K. Takenaga, K. Ohya, I. Ishikawa
Journal of Dental Research   77 1694-1699   Dec 1998   [Refereed]
The periodontal ligament (PDL) is a unique tissue that is crucial for tooth function. However, little is known of the molecular mechanisms controlling PDL function. To characterize PDL cells at the molecular level, we constructed a cDNA library fr...
Iwao Koyama, Iwao Koyama, Mari Yakushijin, Masae Goseki, Tadahiro Iimura, Toyoji Sato, Masaru Sonoda, Shigeru Hokari, Tsugikazu Komoda
Clinica Chimica Acta   275 27-41   Jul 1998   [Refereed]
The lower levels of serum alkaline phosphatase (AP) activity found in patients with diabetes mellitus apparently originate from the selective disappearance or decrease in bone AP activity in the circulation. Hence, we investigated in vitro the eff...
M. Goseki-Sone, H. Orimo, T. Iimura, Y. Takagi, H. Watanabe, K. Taketa, S. Sato, H. Mayanagi, T. Shimada, S. Oida
Human Mutation   11    Jan 1998   [Refereed]
Hideo Orimo, Masae Goseki-Sone, Tadahiro Iimura, Yuzo Takagi, Hisashi Watanabe, Kazuhisa Taketa, Seiji Sato, Hideaki Mayanagi, Akira Ohtake, Shinichiro Oida, Takashi Shimada
Japanese Journal of Human Genetics   42 103   Dec 1997   [Refereed]
Hypophosphatasia (HOPS) is an autosomal recessive disease with skeretal hypomineralization due to deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). We screened the TNSALP gene in 7 Japanese families with HOPS using PCR-SSCP-direct se...
Tadahiro Iimura, Kohsuke Takeda, Masae Gosekp, Yutaka Maruoka, Satoshi Sasaki, Shinichro Oida
Mitochondrial DNA   8 87-92   Dec 1997   [Refereed]
Screening of a human dental pulp cells cDNA library with mouse Msx-1 and Msx-2 cDNA probes led to the isolation of human MSX-2. Sequence and Northern Blotting analysis revealed that two different type of transcripts due to the length of 3′ untrans...
Hiroko N. Matsumoto, Hiroko N. Matsumoto, Asako Yamamoto, Tadahiro Iimura, Shinichiro Oida, Ikuko Ezawa, Satoshi Sasaki, Masae Goseki-Sone
Journal of Nutritional Science and Vitaminology   43 529-539   Nov 1997   [Refereed]
The aim of this study was to investigate the effects of ovariectomy (OVX) on intestinal alkaline phosphatase (ALP) activity in rats. The calcium (Ca) and phosphorus (P) contents and the mechanical strength of bone were decreased significantly by O...
Noriko Osumi, Noriko Osumi, Arisa Hirota, Hideyo Ohuchi, Masato Nakafuku, Tadahiro Iimura, Shigeru Kuratani, Michio Fujiwara, Sumihare Noji, Kazuhiro Eto
Development   124 2961-2972   Sep 1997   [Refereed]
Pax-6 is a member of the vertebrate Pax gene family, which is structurally related to the Drosophila pair-rule gene, paired. In mammals, Pax-6 is expressed in several discrete domains of the developing CNS and has been implicated in neural develop...
Shinichiro Oida, Hidetaka Miyazaki, Tadahiro Iimura, Michiko Suzuki, Satoshi Sasaki, Hitoyata Shimokawa
Mitochondrial DNA   6 307-310   Dec 1996   [Refereed]
A genomic DNA clone (14.5 kbp) for amelogenin, a tooth enamel specific protein, has been isolated from a mouse genomic library. The nucleotide structure of this DNA was determined by the polymerase chain reaction and sequence analysis. The result ...
Masae Goseki-Sone, Masae Goseki-Sone, Shinichiro Oida, Tadahiro Iimura, Asako Yamamoto, Hiroko N. Matsumoto, Naomi Omi, Kohsuke Takeda, Yutaka Maruoka, Ikuko Ezawa, Satoshi Sasaki
Liver   16 358-364   Dec 1996   [Refereed]
The presence of types of alkaline phosphatase (ALP) other than the tissue non-specific type enzyme in rat liver and its increase by fat feeding are known. In order to examine expression of intestinal type ALP in liver, specific oligonucleotide pri...
Tadahiro Iimura, Otto Baba, Yutaka Maruoka, Kohsuke Takeda, Satoshi Sasaki, Hitoyata Shimokawa, Shinichiro Oida
Annals of the New York Academy of Sciences   785 274-277   Sep 1996   [Refereed]
Yasufumi Niinaka, Yasufumi Niinaka, Shin Ichiro Oida, Akira Ishisaki, Kosuke Takeda, Kosuke Takeda, Tadahiro Iimura, Yutaka Maruoka, Fumio Momose, Akihide Negishi, Hidenori Ichijo, Teruo Amagasa, Satoshi Sasaki, Hideomi Watanabe, Avraham Raz, Avraham Raz
International Journal of Oncology   9 433-438   Sep 1996   [Refereed]
Autocrine motility factor (AMF) a tumor-secreted 55 kDa cytokine induces tumor cell motility by a signal transduction pathway mediated by interaction with its receptor (AMFR) a cell surface glycoprotein of 78 kDa (gp78). Here, AMF secreted by the ...
Y. Maruoka, S. Oida, T. Iimura, K. Takeda, I. Asahina, S. Enomoto, S. Sasaki
Biochemistry and Molecular Biology International   35 957-963   Dec 1995   [Refereed]
A clone of a human Bone Morphogenetic Protein-2 (hBMP-2) cDNA was obtained from a cDNA library established from human dental pulp cells. After subcloning hBMP-2 cDNA into Autographa californica nuclear polyhedrosis virus, the recombinant baculovir...
Tadahiro Iimura, Shinichiro Oida, Kohsuke Takeda, Yutaka Maruoka, Hitoyata Shimokawa, Kyomi Ibaraki, Satoshi Sasaki
Mitochondrial DNA   5 233-237   Jan 1995   [Refereed]
Screening of a bovine odontoblast cDNA library from developing incisor with murine Msx-1 and Msx-2 cDNA probes led to the isolation of three positive clones. All of them encoded for a sequence of a protein containing 297 amino acids. The responsib...
M. Goseki, S. Oida, K. Takeda, Y. Ogata, T. Iimura, Y. Maruoka, S. Sasaki
Journal of Dental Research   74 319-322   Jan 1995   [Refereed]
Tissue-nonspecific-type alkaline phosphatase is found in the bone, liver, kidney, and other tissues, and its gene consists of 12 exons with the coding sequence beginning in the second exon. Recently, an alternative noncoding first exon was identif...
S. Kasugai, S. Oida, T. Iimura, N. Arai, K. Takeda, K. Ohya, S. Sasaki
Bone   17 1-4   Jan 1995   [Refereed]
Prostaglandin (PG) E2 displays physiological and pharmacological action in various tissues including bone. It increases intracellular Ca, and stimulates or inhibits CAMP production through the PGE receptor subtypes EP1 EP2, and EP3 respectively. T...
Shinichiro Oida, Tadahiro Iimura, Yutaka Maruoka, Kohsuke Takeda, Satoshi Sasaki
Mitochondrial DNA   5 273-275   Jan 1995   [Refereed]
A cDNA clone encoding bone morphogenetic protein-4 (BMP-4) has been isolated from a human placental cDNA library. Sequence analysis of this clone revealed that the nucleotide sequence of 5' region was different from that of human osteosarcoma BMP-...
T. Iimura
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan   61 590-604   Dec 1994
Although much is known about the hormonal regulation of hard tissue development, much less is known about the nuclear regulatory molecules that affect the process. Homeobox-containing genes are thought to encode DNA-binding transcriptional factors...
T. Iimura, S. Oida, H. Ichijo, M. Goseki, Y. Maruoka, K. Takeda, S. Sasaki
Biochemical and Biophysical Research Communications   204 918-923   Oct 1994   [Refereed]
The effect of TGF-β 1 on the expression of alkaline phosphatase (ALPase) activity was examined during osteoblastic cell line (MG-63) differentiation induced by 1,25-dihydroxyvitamin D3 (1,25D3). TGF-β 1 and 1,25D3 were found to enhance ALPase acti...
K. Takeda, S. Oida, H. Ichijo, T. Iimura, Y. Maruoka, T. Amagasa, S. Sasaki
Biochemical and Biophysical Research Communications   204 203-209   Oct 1994   [Refereed]
A cDNA for the rat bone morphogenetic protein (BMP) type IA receptor (BMPR-IA) was isolated from a dental pulp cell cDNA library. The rat BMPR-IA cDNA encodes a protein of 532 amino acids with a single transmembrane domain and a putative serine/th...
T. Iimura, S. Oida, K. Takeda, Y. Maruoka, S. Sasaki
Biochemical and Biophysical Research Communications   201 980-987   Jun 1994   [Refereed]
Expression of homeobox genes in relation to ectopic bone formation induced by bone morphogenetic protein (BMP) was investigated. Oligonucleotide primers corresponding to highly conserved regions of Hox cluster and Msx genes were designed to detect...
K. Takeda, K. Takeda, S. Oida, M. Goseki, T. Iimura, Y. Maruoka, Y. Maruoka, T. Amagasa, S. Sasaki
Bone   15 467-470   Jan 1994   [Refereed]
Dental pulp has a potential to induce ectopic bone formation, but little is known about its mechanism. We thought that bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β) superfamily, are involved in the osteoin...

Conference Activities & Talks

Retrieval of regulatory mode of G1/S transition in vertebrate axial development by quantitative live imaging and mathematical models [Invited]
IIMURA Tadahiro
The 37th Naito Conference   16 Jun 2014   
Fluorescence morphometric analysis of mechano-sensing osteocytes in bone [Invited]
IIMURA Tadahiro
International Symposium on Mechanobiology 2014   22 May 2014   
Multi-dimensional fluorescence imaging approaches for embryonic development and bone biology [Invited]
IIMURA Tadahiro
8th Meeting of Bone Biology Forum   20 Aug 2011   
Real time fluorescence imaging in early embryonic body formation [Invited]
IIMURA Tadahiro
The 26th Naito Conference   11 Oct 2009   
Morphogenetic implications of the segmentation clock and Hox genes in early embryonic spine formation [Invited]
IIMURA Tadahiro
Tokyo Medical and Dental University Global COE Opening Symposium   6 Sep 2008   
Regulation and function of Hox genes during chick paraxial mesoderm development
IIMURA Tadahiro
22 Jul 2008   
Collinear activation of Hoxb genes during gastrulation controls the timing of mesoderm formation, The 39th Developmemtal Biology Meeting [Invited]
Iimura T and Pourquie O
The 39th Developmemtal Biology Meeting, Symposium 1:Vertebrate axis formation: Translation of temporal and spatial information   1 Jun 2006   
A two-step mechanism is involved in the collinear positioning of Hox gene expression boundaries along the vertebrate skeletal axis
Iimura T, Millet S, Malapert P, Dubrulle J and Pourquié O
44th Annual Midwest Regional Developmental Biology Meeting and Singer Symposium   6 Jun 2004   
BMPs as a cartilage inducer during mammalian face development.
Iimura T, Imai H, Ishiguro K, Ikeda Y and Eto E.
77th General Session & Exhibition of the IADR   8 Mar 1999