論文

査読有り 国際誌
2004年10月

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.

Nature immunology
  • Taro Kawai
  • Shintaro Sato
  • Ken J Ishii
  • Cevayir Coban
  • Hiroaki Hemmi
  • Masahiro Yamamoto
  • Kenta Terai
  • Michiyuki Matsuda
  • Jun-ichiro Inoue
  • Satoshi Uematsu
  • Osamu Takeuchi
  • Shizuo Akira
  • 全て表示

5
10
開始ページ
1061
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/ni1118
出版者・発行元
NATURE PUBLISHING GROUP

Toll-like receptors (TLRs) are involved in the recognition of microbial pathogens. A subset of TLRs, TLR7, TLR8 and TLR9, induces antiviral responses by producing interferon-alpha (IFN-alpha). Production of IFN-alpha is dependent on the Toll-interleukin-1 receptor domain-containing adaptor MyD88. Here we show that MyD88 formed a complex with the transcription factor IRF7 but not with IRF3. The death domain of MyD88 interacted with an inhibitory domain of IRF7, and this interaction resulted in activation of the IFN-alpha-dependent promoters. Furthermore, the adaptor molecule TRAF6 also bound and activated IRF7. Ubiquitin ligase activity of TRAF6 was required for IRF7 activation. These results indicate that TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination.

リンク情報
DOI
https://doi.org/10.1038/ni1118
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15361868
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000224156600030&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=5444274514&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=5444274514&origin=inward
ID情報
  • DOI : 10.1038/ni1118
  • ISSN : 1529-2908
  • PubMed ID : 15361868
  • SCOPUS ID : 5444274514
  • Web of Science ID : WOS:000224156600030

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