Chikako Shimokawa - My portal

Profile Information

Affiliation: Department of Parasitology, National Institute of Infectious Diseases

Degree: 博士（医学）

J-GLOBAL ID: 201601020755792840
researchmap Member ID: 7000016060

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Department of Parasitology, National Institute of Infectious Diseases
Jun, 2019 - Present

National Institute of Infectious Diseases
Apr, 2015 - Present

客員研究員, 粘膜システム研究チーム, 理化学研究所生命医科学研究センター
Apr, 2015 - May, 2019

Graduate School of Medicine, Gunma University

Committee Memberships

2021 - Present

評議員, 日本寄生虫学会
2017 - Present

免疫ふしぎ未来実行委員, 日本免疫学会

Awards

Jul, 2019

第12回資生堂女性研究者サイエンスグラント, 資生堂

下川周子
Mar, 2019

奨励賞, 日本寄生虫学会

下川周子
2015

Tadamitsu Kishimoto Travel Award, 日本免疫学会

下川周子
2014

ICOPAトラベルアワード, 日本寄生虫学会

下川周子
Mar, 2013

学長賞, 長崎大学

下川周子
Mar, 2013

第7回ベストプレゼンテーション賞, 日本寄生虫学会

下川周子
Apr, 2012

学術褒賞, 群馬大学

下川周子
Apr, 2011

宮崎一郎奨励賞, 九州大学寄生虫学講座

下川周子

Papers

Prevalence and metronidazole resistance of Trichomonas vaginalis among Japanese women in 2021

Yumiko Saito-Nakano, Yuko Umeki, Chikako Shimokawa, Koichi Kobayashi, Koichi Hashimoto, Toshio Takada, Chinami Makii, Rie Hasebe, Yuri Yoshida, Riko Nakajima …

IJID Regions, Jun, 2023 Peer-reviewed
The impact of the gut microbiome on extra-intestinal autoimmune diseases.

Eiji Miyauchi, Chikako Shimokawa, Alex Steimle, Mahesh S Desai, Hiroshi Ohno

Nature reviews. Immunology, May 9, 2022
Long-term acrylamide exposure exacerbates brain and lung pathology in a mouse malaria model.

Ha Ngo-Thanh, Trang Dam Thuy, Kazutomo Suzue, Wataru Kamitani, Hideaki Yokoo, Koji Isoda, Chikako Shimokawa, Hajime Hisaeda, Takashi Imai

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 151 112132-112132, May, 2021
Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator.

Shruti Nagaraja, Maggi W Cai, Jingjing Sun, Hugo Varet, Lotem Sarid, Meirav Trebicz-Geffen, Yana Shaulov, Mohit Mazumdar, Rachel Legendre, Jean-Yves Coppée …

mBio, 12(2), Mar 9, 2021
Author Correction: CD8+ T cell activation by murine erythroblasts infected with malaria parasites.

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Tomohisa Suzuki, Chikako Shimokawa, Hajime Hisaeda

Scientific reports, 10(1) 20195-20195, Nov 13, 2020
Blood–cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA

Ha Ngo-Thanh, Tsutomu Sasaki, Kazutomo Suzue, Hideaki Yokoo, Koji Isoda, Wataru Kamitani, Chikako Shimokawa, Hajime Hisaeda, Takashi Imai

International Journal for Parasitology, 50(14) 1167-1175, Sep, 2020
Potential and Limitations of Cross-Protective Vaccine against Malaria by Blood-Stage Naturally Attenuated Parasite

Takashi Imai, Kazutomo Suzue, Ha Ngo-Thanh, Chikako Shimokawa, Hajime Hisaeda

Vaccines, 8(3) 375-375, Jul 11, 2020
CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Shimokawa C, Kato T, Takeuchi T, Ohshima N, Furuki T, Otsu Y, Suzue K, Imai T, Obi S, Olia A …

Nature communications, 11(1) 1922-1922, Apr, 2020 Peer-reviewedLead authorCorresponding author
IL-33 is essential to prevent high fat diet-induced obesity in mice infected with an intestinal helminth.

Seiji Obi, Chikako Shimokawa, Mizuki Katsuura, Alex Olia, Takashi Imai, Kazutomo Suzue, Hajime Hisaeda

Parasite immunology, 42(9) e12700, Feb 6, 2020 Peer-reviewed
Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma.

Alex Olia, Chikako Shimokawa, Takashi Imai, Kazutomo Suzue, Hajime Hisaeda

Parasitology international, 76 102057-102057, Jan, 2020 Peer-reviewed
Suppression of Obesity by an Intestinal Helminth through Interactions with Intestinal Microbiota.

Chikako Shimokawa, Seiji Obi, Mioko Shibata, Alex Olia, Takashi Imai, Kazutomo Suzue, Hajime Hisaeda

Infection and immunity, 87(6), Jun, 2019 Peer-reviewed
Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection

Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H …

European Journal of Immunology, 2019 Peer-reviewed
Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii.

Takashi Imai, Kazutomo Suzue, Ha Ngo-Thanh, Suguri Ono, Wakako Orita, Haruka Suzuki, Chikako Shimokawa, Alex Olia, Seiji Obi, Tomoyo Taniguchi …

Frontiers in immunology, 10 2207-2207, 2019 Peer-reviewed
Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate.

Yana Shaulov, Chikako Shimokawa, Meirav Trebicz-Geffen, Shruti Nagaraja, Karen Methling, Michael Lalk, Lea Weiss-Cerem, Ayelet T Lamm, Hajime Hisaeda, Serge Ankri

PLoS pathogens, 14(10) e1007295, Oct, 2018 Peer-reviewed
Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ.

Chikako Shimokawa, Masachika Senba, Seiki Kobayashi, Mihoko Kikuchi, Seiji Obi, Alex Olia, Shinjiro Hamano, Hajime Hisaeda

Journal of immunology (Baltimore, Md. : 1950), 200(3) 1101-1109, Feb 1, 2018 Peer-reviewed
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.

Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno

Immunity, 46(5) 863-874, May 16, 2017 Peer-reviewed
ALTERED GUT MICROBIOTA COMPOSITION IN PLASMODIUM FALCIPARUM PATIENTS IN UGANDA

Taniguchi Tomoyo, Miyauchi Eiji, Olia Alex, Nagayasu Eiji, Osbert Katuro, Suzue Kazutomo, Imai Takashi, Shimokawa Chikako, Onishi Risa, Odongo-Aginya Emmanuel I …

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 97(5) 288-288, 2017 Peer-reviewed
Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis (vol 5, 15699, 2015)

Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura, Makoto Hirai, Kazutomo Suzue, Takashi Imai, Takahiro Nomura, Tadashi Handa, Hiroko Okada, Chikako Shimokawa …

SCIENTIFIC REPORTS, 6 17248-17248, Jan, 2016 Peer-reviewed
Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis.

Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura, Makoto Hirai, Kazutomo Suzue, Takashi Imai, Takahiro Nomura, Tadashi Handa, Hiroko Okada, Chikako Shimokawa …

Scientific reports, 5 15699-15699, Oct 27, 2015 Peer-reviewed
Cytotoxic activities of CD8(+) T cells collaborate with macrophages to protect against blood-stage murine malaria

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda

ELIFE, 4, Mar, 2015 Peer-reviewed

Misc.

Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-gamma

Chikako Shimokawa, Masachika Senba, Seiki Kobayashi, Mihoko Kikuchi, Seiji Obi, Alex Olia, Shinjiro Hamano, Hajime Hisaeda

JOURNAL OF IMMUNOLOGY, 200(3) 1101-1109, 2018
Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-gamma

Shimokawa, Chikako, Senba, Masachika, Kobayashi, Seiki, Kikuchi, Mihoko, Obi, Seiji, Olia, Alex, Hamano, Shinjiro, Hisaeda, Hajime

JOURNAL OF IMMUNOLOGY, 200(3) 1101-1109, 2018
ウガンダ国の熱帯熱マラリア患者において腸内細菌叢の変化が起こる

谷口委代, 宮内栄治, Olia Alex, 長安英治, Osbert Katuro, 鈴江一友, 今井孝, 下川周子, 大西里咲, Odongo-Aginya E.I …

グローバルヘルス合同大会プログラム・抄録集, 2017 192-192, Nov, 2017
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.

Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno

Immunity, 46(5) 863-874, May 16, 2017
Pathogen non-specific bystander T cells were attenuated upon infection with malaria parasites

K. Suzue, H. Amano, T. Taniguchi, C. Shimokawa, A. Olia, R. Onishi, H. Hisaeda

EUROPEAN JOURNAL OF IMMUNOLOGY, 46 706-706, Aug, 2016
Plasmodium berghei ANKA infection induces intestinal dysbiosis

T. Taniguchi, E. Miyauchi, S. Nakamura, M. Hirai, K. Suzue, T. Imai, T. Nomura, H. Okada, C. Shimokawa, R. Onishi …

EUROPEAN JOURNAL OF IMMUNOLOGY, 46 461-461, Aug, 2016
Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis

Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura, Makoto Hirai, Kazutomo Suzue, Takashi Imai, Takahiro Nomura, Tadashi Handa, Hiroko Okada, Chikako Shimokawa …

SCIENTIFIC REPORTS, 5 15669, Oct, 2015
Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis

Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura, Makoto Hirai, Kazutomo Suzue, Takashi Imai, Takahiro Nomura, Tadashi Handa, Hiroko Okada, Chikako Shimokawa …

SCIENTIFIC REPORTS, 5 15669, Oct, 2015
A transient resistance to blood-stage malaria in interferon-gamma-deficient mice through impaired production of the host cells preferred by malaria parasites

Hiroko Okada, Kazutomo Suzue, Takashi Imai, Tomoyo Taniguchi, Chikako Shimokawa, Risa Onishi, Jun Hirata, Hajime Hisaeda

FRONTIERS IN MICROBIOLOGY, 6 600, Jun, 2015
A transient resistance to blood-stage malaria in interferon-gamma-deficient mice through impaired production of the host cells preferred by malaria parasites

Hiroko Okada, Kazutomo Suzue, Takashi Imai, Tomoyo Taniguchi, Chikako Shimokawa, Risa Onishi, Jun Hirata, Hajime Hisaeda

FRONTIERS IN MICROBIOLOGY, 6 600, Jun, 2015
Cytotoxic activities of CD8⁺ T cells collaborate with macrophages to protect against blood-stage murine malaria.

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda

eLife, 4 e04232, Mar 11, 2015 Peer-reviewed
Cytotoxic activities of CD8(+) T cells collaborate with macrophages to protect against blood-stage murine malaria

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda

ELIFE, 4 e04232, Mar, 2015
Species-Specific Immunity Induced by Infection with Entamoeba histolytica and Entamoeba moshkovskii in Mice

Chikako Shimokawa, Richard Culleton, Takashi Imai, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Seiki Kobayashi, Hajime Hisaeda, Shinjiro Hamano

PLOS ONE, 8(11) e82025, Nov, 2013
IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages.

Hidekazu Ishida, Takashi Imai, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Akihiko Yoshimura, Yoichiro Iwakura, Hiroko Okada, Tomohisa Suzuki, Chikako Shimokawa …

European journal of immunology, 43(10) 2696-706, Oct, 2013 Peer-reviewed
Resistance to Malaria by Enhanced Phagocytosis of Erythrocytes in LMP7-deficient Mice

Xuefeng Duan, Takashi Imai, Bin Chou, Liping Tu, Kunisuke Himeno, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa …

PLOS ONE, 8(3) e59633, Mar, 2013
CD8(+) T cell activation by murine erythroblasts infected with malaria parasites

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Tomohisa Suzuki, Chikako Shimokawa, Hajime Hisaeda

SCIENTIFIC REPORTS, 3 1572, Mar, 2013
Resistance to Malaria by Enhanced Phagocytosis of Erythrocytes in LMP7-deficient Mice

Xuefeng Duan, Takashi Imai, Bin Chou, Liping Tu, Kunisuke Himeno, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa …

PLOS ONE, 8(3) e59633, Mar, 2013
CD8(+) T cell activation by murine erythroblasts infected with malaria parasites

Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Tomohisa Suzuki, Chikako Shimokawa, Hajime Hisaeda

SCIENTIFIC REPORTS, 3 1572, Mar, 2013
Species-Specific Immunity Induced by Infection with Entamoeba histolytica and Entamoeba moshkovskii in Mice

Shimokawa, Chikako, Culleton, Richard, Imai, Takashi, Suzue, Kazutomo, Hirai, Makoto, Taniguchi, Tomoyo, Kobayashi, Seiki, Hisaeda, Hajime, Hamano, Shinjiro

PLOS ONE, 8(11) e82025, 2013
IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages

Ishida, Hidekazu, Imai, Takashi, Suzue, Kazutomo, Hirai, Makoto, Taniguchi, Tomoyo, Yoshimura, Akihiko, Iwakura, Yoichiro, Okada, Hiroko, Suzuki, Tomohisa, Shimokawa, Chikako …

EUROPEAN JOURNAL OF IMMUNOLOGY, 43(10) 2696-2706, 2013

Books and Other Publications

重要な鍵分子の研究動向〜1型糖尿病

最新の免疫学・科学技術情報協会, 2021
1型糖尿病発症と腸内細菌

糖尿病・内分泌代謝科、科学評論社, 2021
寄生虫と腸内細菌の相互作用

実験医学・羊土社, 2021
腸内細菌による1型糖尿病の制御

臨床免疫アレルギー科, 2021
自己免疫疾患としての一型糖尿病と腸内細菌との関連

下川周子

実験医学 / 羊土社, 2019
腸管寄生虫と腸内細菌のクロストークによる１型糖尿病抑制メカニズム

下川周子, 久枝一

臨床免疫・アレルギー科 / 科学評論社, 2019
腸管寄生性線虫感染排除における肥満細胞の新たな役割

下川周子

臨床免疫・アレルギー科 / 科学評論社, 2018
肥満細胞の寄生虫感染に対する新たな機能

下川周子

感染・炎症・免疫 / 医薬の門社, 2018
肥満細胞の新たな機能- 寄生虫の新しい初期感染防御メカニズム

下川周子

ファルマシア / 日本薬学会, 2018
寄生虫感染モデルからみえたアレルギー病態形成

下川周子, 大野博司

医学のあゆみアレルギー研究最前線 / 医歯薬出版株式会社, 2018
寄生虫感染と粘膜免疫

下川周子

医学のあゆみ粘膜免疫Update / 医歯薬出版株式会社, 2015
ジアルジア症、自由生活アメーバ症、赤痢アメーバ症

濱野真二郎, 下川周子

感染症辞典 / オーム社, 2012

Professional Memberships

Research Projects

Parasitomimetics: Identification and application of highly functional factors of parasites

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (B), Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, May, 2022 - Mar, 2025
寄生虫由来物質による宿主-腸内細菌間相互作用の解明

科学研究費助成事業学術変革領域研究(B), 学術変革領域研究(B), 日本学術振興会, May, 2022 - Mar, 2025

下川周子
宿主ー腸内細菌叢相互作用が宿主の病理に及ぼす影響の研究

科学研究費助成事業基盤研究(A), 基盤研究(A), 日本学術振興会, Apr, 2022 - Mar, 2025

大野博司, 中西裕美子, 加藤完, 伊藤崇, 宮内栄治, 下川周子
アニサキスアレルギーの全貌解明に向けた基盤的研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

下川周子
寄生虫感染モデルを基盤にした一型糖尿病に対する新規治療法の開発

第3回内藤記念次世代育成支援研究助成金, 公益財団法人内藤記念科学振興財団, 2019 - 2023

下川周子
The impact of gut microbiota on autoimmune diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Ohno Hiroshi
自己免疫疾患制御へ向けた新規制御性細胞の誘導メカニズムの解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2019 - Mar, 2022

下川周子
腸管寄生蠕虫感染モデルから明らかとなった自己免疫疾患の予防、治療補助法の開発

資生堂, Jul, 2019 - Jul, 2020

下川周子
一型糖尿病制御に向けた新たな治療法の開発

平成30年度研究奨励金, 公益財団法人上原記念生命科学財団, 2019

下川周子
寄生虫感染モデルを利用した1型糖尿病の抑制に関わる新規制御性T細胞を誘導する腸内細菌の探索

平成31年度日本人若手研究者研究助成金, 公益財団法人中島記念国際交流財団, 2019

下川周子
衛生仮説の科学的証明に向けた宿主-寄生虫-腸内細菌ネットワークの解明

一般研究助成, 公益財団法人ヤクルトバイオサイエンス研究財団, 2019

下川周子
Ⅰ型糖尿病を抑制する新規免疫細胞CD8Tregの誘導メカニズムについて

一般研究助成, 群馬大学, 2018

下川周子
一型糖尿病発症抑制に関わるCD8陽性制御性T細胞の誘導メカニズム

2018年度研究助成（基礎）, 公益財団法人武田科学振興財団, 2018

下川周子
寄生虫感染で誘導された新規制御性T細胞は自己免疫疾患を抑制する

第32回基礎医学医療研究助成金, 金原一郎記念医学医療振興財団, 2017

下川周子
Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2014 - 2016

Shimokawa Chikako
肥満細胞を起点とした腸管寄生線虫に対する新規防御メカニズムの解明

大山健康財団, 2014

下川周子
腸管寄生原虫である赤痢アメーバに対する宿主側感染防御機構の解明

笹川科学研究助成, 日本科学協会, 2012

下川周子

Industrial Property Rights

特願2017-94949 制御性T細胞増強剤並びにそれを含む医薬及び食品組成物

久枝一, 下川周子, 和泉孝志, 大嶋紀安, 大野博司, 加藤完