論文

査読有り 国際誌
2018年4月

Short-term administration of recombinant human erythropoietin decreases B cell number in human peripheral blood.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • Tomomi Nagashima
  • ,
  • Akihiko Yokohama
  • ,
  • Kie Nagai
  • ,
  • Tetsuhiro Kasamatsu
  • ,
  • Nanami Gotoh
  • ,
  • Hirono Iriuchishima
  • ,
  • Tomomi Sekigami
  • ,
  • Takayuki Saitoh
  • ,
  • Hiroshi Handa
  • ,
  • Norifumi Tsukamoto
  • ,
  • Hirokazu Murakami

57
2
開始ページ
208
終了ページ
214
記述言語
英語
掲載種別
DOI
10.1016/j.transci.2018.01.009

OBJECTIVES: There are conflicting results on the influence of recombinant human erythropoietin (rHuEPO) administration to lymphocytes, especially to B cells. METHODS: We analyzed peripheral white blood cell (WBC) subsets in patients who received one bolus administration of rHuEPO. 119 autologous blood donors were enrolled in this study. Fourty-nine out of them were treated with rHuEPO. Blood samples were obtained before the first phlebotomy and one week later before the second one. By flow cytometry, we measured the numbers of WBC, lymphocytes, dendritic cells, CD4+ T cells, CD8+ T cells, natural killer (NK) cells, B cells, monocytes, and neutrophils, further details of B cell subsets. RESULTS: In the EPO-treatment group, absolute numbers of lymphocytes, especially CD8+ T cells, NK cells, and B cells, significantly decreased after rHuEPO administration. In B cell subsets, absolute numbers of naïve B cells and IgD-CD27- B cells significantly decreased. Other B cell subsets, such as transitional B cells, memory B cells, and marginal zone B cells, also showed a decreasing trend. CONCLUSION: These findings suggest that a single administration of rHuEPO can influence human immune system via reduction of B cell number in peripheral blood.

リンク情報
DOI
https://doi.org/10.1016/j.transci.2018.01.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29439918