論文

査読有り
2017年10月

Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance

ONCOLOGY LETTERS
  • Hiroshi Handa
  • ,
  • Yoshiko Sasaki
  • ,
  • Hikaru Hattori
  • ,
  • Lobna Alkebsi
  • ,
  • Tetsuhiro Kasamatsu
  • ,
  • Takayuki Saitoh
  • ,
  • Takeki Mitsui
  • ,
  • Akihiko Yokohama
  • ,
  • Norifumi Tsukamoto
  • ,
  • Morio Matsumoto
  • ,
  • Hirokazu Murakami

14
4
開始ページ
4372
終了ページ
4378
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ol.2017.6672
出版者・発行元
SPANDIDOS PUBL LTD

The putative tumor suppressor gene WW domain containing oxidoreductase (WWOX) spans a common fragile site (CFS) on chromosome 16q23.3. CFSs are regions of profound genomic instability and sites for genomic deletions in cancer cells. Therefore, WWOX is structurally altered in diverse nonhematological cancer types. However, the function of WWOX in hematological tumor types, including multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) remains unclear. WWOX expression and methylation in patients with MM, MGUS, or noninvasive lymphoma (control) were analyzed using reverse transcriptionand methylation specific-polymerase chain reaction analysis. Variant WWOX transcripts were detected in 65 and 50% of patients with MM and MGUS, respectively, compared with 10% of controls. WWOX expression was higher in patients with MM, and WWOX promoter methylation was detected in 35% of patients with MM compared with 5% of patients with MGUS and 4% of controls. WWOX promoter methylation was significantly associated with shorter overall survival time of patients, in particular those with MM who were never treated with novel agents. Genomic alterations, including deletions and promoter methylation that affect WWOX expression occur early and may be involved in the pathogenesis, progression, and prognosis of MM.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.3892/ol.2017.6672
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28943951
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413151300068&DestApp=WOS_CPL