論文

2011年10月

Interleukin-10 gene polymorphism reflects the severity of chronic immune thrombocytopenia in Japanese patients

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • T. Saitoh
  • ,
  • T. Kasamatsu
  • ,
  • M. Inoue
  • ,
  • T. Mitsui
  • ,
  • H. Koiso
  • ,
  • A. Yokohama
  • ,
  • H. Handa
  • ,
  • T. Matsushima
  • ,
  • N. Tsukamoto
  • ,
  • M. Karasawa
  • ,
  • H. Ogawara
  • ,
  • Y. Nojima
  • ,
  • H. Murakami

33
5
開始ページ
526
終了ページ
532
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1751-553X.2011.01320.x
出版者・発行元
WILEY

Introduction: T-helper cell type 1 (Th1) polarization of the immune response has been documented in patients with chronic immune thrombocytopenia (ITP). Interleukin (IL)-10 is the most important factor regulating Th1 and T-helper type 2 cytokine synthesis. This study evaluated the impact of IL-10 polymorphisms on both susceptibility to, and severity of, chronic ITP.
Methods: We analyzed - 1082(G/A), -812(C/T), and -592(C/A) IL-10 polymorphisms in 90 patients with adult chronic ITP and 202 race- and sex-matched healthy controls.
Results: No significant differences in the genotype or haplotype frequencies were observed between the patient with chronic ITP and the control group. However, more patients with the -592AA genotype showed a severe thrombocytopenic state (platelet count <10 x 10(9)/l) than those with the -592CC/CA genotypes (44.1% vs. 19.6%, P = 0.01). Furthermore, more patients with the ATA/ATA haplotype showed a severe thrombocytopenic state than those without the ATA/ATA haplotype (44.1% vs. 19.6%, P = 0.01).
Conclusion: According to our data, patients with low producer type of IL-10 polymorphisms have more severe thrombocytopenia, suggesting that IL-10 gene polymorphisms may reflect the severity of ITP.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.1111/j.1751-553X.2011.01320.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000294131200014&DestApp=WOS_CPL

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