論文

査読有り
2018年5月1日

High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients

International Journal of Gynecological Cancer
  • Kohshiro Nakao
  • ,
  • Takashi Hirakawa
  • ,
  • Hiroto Suwa
  • ,
  • Kayoko Kogure
  • ,
  • Sadatomo Ikeda
  • ,
  • Soichi Yamashita
  • ,
  • Takashi Minegishi
  • ,
  • Hiroshi Kishi

28
4
開始ページ
675
終了ページ
683
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/IGC.0000000000001201
出版者・発行元
Lippincott Williams and Wilkins

Objective: The ubiquitin C-terminal hydrolase L1 (UCHL1) plays a key role in tumor invasion and metastasis. Ubiquitin C-terminal hydrolase L1 is overexpressed in various cancers and reported to be correlated with a poor prognosis. The objective of this study was to determine the prognostic significance of UCHL1 in endometrial cancer. Methods: The expression of UCHL1 in endometrial cancer was assessed using quantitative reverse transcription polymerase chain reaction and immunohistochemistry in 56 and 215 resected tumor specimens, respectively. Results: The 4-year survival rates of the high UCHL1 messenger RNA expression group and high UCHL1 protein expression group were 78% and 71%, respectively, compared with 96% and 95% for the low UCHL1 messenger RNA expression group and low UCHL1 protein expression group, respectively. Kaplan-Meier and log-rank tests indicated a significant correlation between expression of UCHL1 and disease-free survival and overall survival. Moreover, multivariate stepwise Cox proportional hazard regression model analysis showed that UCHL1 was a significant independent marker for predicting a poor disease-free survival and overall survival. In 43 patients with metastatic lesions, immunohistochemical analysis of metastatic lesions revealed that the recurrence rate and mortality rate were 62% and 41%, respectively, in 29 UCHL1-positive patients and 36% and 29%, respectively, in 14 UCHL1-negative patients. Conclusions: The results of this study suggest that high UCHL1 expression is a strong marker of poor prognosis of endometrial cancer. Furthermore, we suggest that UCHL1 may be involved in the development of distant metastasis in endometrial cancer.

リンク情報
DOI
https://doi.org/10.1097/IGC.0000000000001201
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29489474

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